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GW806742X

GW806742X structure

CAS No.: 579515-63-2

Chemical Name:: GW806742X

Synonyms: CS-2659;GW806742X;GW806742X ≥95%;GW806742X >=98% (HPLC);GW806742X;GW-806742X;GW 806742X;1-[4-[methyl-[2-(3-sulfamoylanilino)pyrimidin-4-yl]amino]phenyl]-3-[4-(trifluoromethoxy)phenyl]urea;3-((4-(Methyl(4-(3-(4-(trifluoromethoxy)phenyl)ureido)phenyl)amino)pyrimidin-2-yl)amino)benzenesulfonamide;Benzenesulfonamide, 3-[[4-[methyl[4-[[[[4-(trifluoromethoxy)phenyl]amino]carbonyl]amino]phenyl]amino]-2-pyrimidinyl]amino]-;VEGFR,death,GW806742X,translocation,GW-806742X,Vascular endothelial growth factor receptor,membrane,Inhibitor,TSQ,MLKs,inhibit,HUVEC,Mixed Lineage Kinase,necroptotic

CBNumber:: CB23067556

Molecular Formula:: C25H22F3N7O4S

Molecular Weight:: 573.55

MDL Number:: MFCD29036385

MOL File:: 579515-63-2.mol

Last updated:2024-07-02 08:55:03

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GW806742X Properties

Density	1.524±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO:100.0(Max Conc. mg/mL);174.35(Max Conc. mM)
form	Solid
pka	10.09±0.60(Predicted)
color	White to off-white

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P280-P301+P312-P302+P352-P305+P351+P338

GW806742X price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	SML1990	GW806742X ≥98% (HPLC)	579515-63-2	5MG	$131	2024-03-01	Buy
Sigma-Aldrich	SML1990	GW806742X ≥98% (HPLC)	579515-63-2	25MG	$530	2024-03-01	Buy
Adipogen Life Sciences	SYN-1215-M050	GW806742X ≥95%	579515-63-2	50mg	$918	2021-12-16	Buy
AK Scientific	SYN1215	GW806742X	579515-63-2	10mg	$340	2021-12-16	Buy
ChemScene	CS-0044745	GW806742X 98.09%	579515-63-2	100mg	$450	2021-12-16	Buy

Product number	Packaging	Price	Buy
SML1990	5MG	$131	Buy
SML1990	25MG	$530	Buy
SYN-1215-M050	50mg	$918	Buy
SYN1215	10mg	$340	Buy
CS-0044745	100mg	$450	Buy

GW806742X Chemical Properties,Uses,Production

Biological Activity

GW806742X, an ATP mimetic, is a potent MLKL inhibitor that binds the MLKL pseudokinase domain with a Kd of 9.3μM. It has anti-VEGFR2 activity (IC50=2 nM). It delays MLKL membrane translocation and inhibits necrosis.

in vitro

GW806742X (0.1-10000 nM) inhibits necroptotic death of wild-type mouse dermal fibroblasts (MDFs) stimulated with TSQ (1 ng/mL TNF, 500 nM compound A (Smac mimetic), 10 μM Q-VD -OPh) in a dose-dependent manner. GW806742X shows inhibition of VEGF induced proliferation of HUVECs with an IC50 of 5 nM.

target

MLKL

9.3 μM (Kd)

VEGFR2

2 nM (IC _{50 < /sub> )}

GW806742X Preparation Products And Raw materials

Raw materials

Preparation Products

GW806742X Suppliers

Global( 48)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32760	60
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	sales@chemhifuture.com	China	3136	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43348	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	52927	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131980	58
Wuhan TCASChem Technology Co., Ltd.	027-027-86697669 13986148687	sales@tcaschem.com	China	3888	55
ShangHai Caerulum Pharma Discovery Co., Ltd.	18149758185	sales-cpd@caerulumpharma.com	China	3453	58
Shanghai Lollane Biological Technology Co.,Ltd.	021-52996696，15000506266 15000506266		China	4217	55

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
TargetMol Chemicals Inc.	58
InvivoChem	58
Nantong HI-FUTURE Biology Co., Ltd.	58
LEAPCHEM CO., LTD.	58
Aladdin Scientific	58
Amadis Chemical Company Limited	58
Wuhan TCASChem Technology Co., Ltd.	55
ShangHai Caerulum Pharma Discovery Co., Ltd.	58
Shanghai Lollane Biological Technology Co.,Ltd.	55

GW806742X Spectrum

GW806742X(579515-63-2)¹HNMR

579515-63-2(GW806742X)Related Search:

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GW 6471

1of2

GW806742X 3-((4-(Methyl(4-(3-(4-(trifluoromethoxy)phenyl)ureido)phenyl)amino)pyrimidin-2-yl)amino)benzenesulfonamide GW806742X >=98% (HPLC) Benzenesulfonamide, 3-[[4-[methyl[4-[[[[4-(trifluoromethoxy)phenyl]amino]carbonyl]amino]phenyl]amino]-2-pyrimidinyl]amino]- GW806742X ≥95% 1-[4-[methyl-[2-(3-sulfamoylanilino)pyrimidin-4-yl]amino]phenyl]-3-[4-(trifluoromethoxy)phenyl]urea GW806742X;GW-806742X;GW 806742X CS-2659 VEGFR,death,GW806742X,translocation,GW-806742X,Vascular endothelial growth factor receptor,membrane,Inhibitor,TSQ,MLKs,inhibit,HUVEC,Mixed Lineage Kinase,necroptotic 579515-63-2 C25H22F3N7O4S