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4,5-Dimethyl-1,3-dioxol-2-one

4,5-Dimethyl-1,3-dioxol-2-one structure

CAS No.: 37830-90-3

Chemical Name:: 4,5-Dimethyl-1,3-dioxol-2-one

Synonyms: DMDO;4,5-Dimethyl-1,3-dioxolen-2-one;DIMETHYLDIOXOLONE;AZATMint-A;3-dioxol-2-one;ORDIMETHYLDIOXOLONE;4,5-Dimethyl-1,3-dio;Olmesartan Impurity 54;Dimethylvinylene carbonate;5-Dimethyl-1,3-dioxol-2-one

CBNumber:: CB2310781

Molecular Formula:: C5H6O3

Molecular Weight:: 114.1

MDL Number:: MFCD00135139

MOL File:: 37830-90-3.mol

MSDS File:: SDS

Last updated:2024-06-15 22:11:33

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4,5-Dimethyl-1,3-dioxol-2-one Properties

Melting point	78°C
Boiling point	130 °C / 6mmHg
Density	1.181±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Chloroform, Methanol
form	Solid
color	White
InChIKey	QYIOFABFKUOIBV-UHFFFAOYSA-N
CAS DataBase Reference	37830-90-3(CAS DataBase Reference)
NIST Chemistry Reference	1,3-Dioxol-2-one,4,5-dimethyl-(37830-90-3)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319
Precautionary statements	P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313
Risk Statements	36/37/38-37-36
Safety Statements	26-36/37/39-36
HS Code	29329990

4,5-Dimethyl-1,3-dioxol-2-one price More Price(21)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	TMT00459	4,5-Dimethyl-1,3-dioxol-2-one	37830-90-3	1G	$512	2023-06-20	Buy
TCI Chemical	D1920	4,5-Dimethyl-1,3-dioxol-2-one >99.0%(GC)	37830-90-3	25g	$49	2024-03-01	Buy
TRC	D472660	4,5-Dimethyl-1,3-dioxol-2-one	37830-90-3	100g	$395	2021-12-16	Buy
Matrix Scientific	075732	4,5-Dimethyl-1,3-dioxol-2-one 95+%	37830-90-3	100g	$399	2021-12-16	Buy
Frontier Specialty Chemicals	JK373976	4,5-Dimethyl-1,3-dioxol-2-one 99%	37830-90-3	5g	$64	2021-12-16	Buy

Product number	Packaging	Price	Buy
TMT00459	1G	$512	Buy
D1920	25g	$49	Buy
D472660	100g	$395	Buy
075732	100g	$399	Buy
JK373976	5g	$64	Buy

4,5-Dimethyl-1,3-dioxol-2-one Chemical Properties,Uses,Production

Chemical Properties

White Solid

Uses

4,5-Dimethyl-1,3-dioxol-2-one is a dioxolanone derivative used in the preparation of synthetic chemotherapeutic antibiotics such as Prulifloxacin (P838885).

Application

4,5-Dimethyl-1,3-dioxol-2-one is a kind of important medicine intermediate, is mainly used in the modification of many medicines, to synthesize, has optically active chiral drug, thereby improves largely drug effect, reduces drug side effect.

Synthesis

1. distillation column is being housed, air set pipe, mechanical stirrer, add 3-hydroxy-2-butanone 88g, methylcarbonate 90g, tirethylene glycol dme 264g and sodium propylate 0.88g in the three-necked flask of thermometer, at 60-65 ℃ of reacting by heating mixture, carry out transesterification reaction 6h, the methyl alcohol of generation is removed in synchronous distillation, obtains carbonic acid monomethyl 3-hydroxy-2-butanone base ester.
2. improve reaction mixture temperature to 110-115 ℃, keep this thermotonus 5h, continue to steam the by products such as methyl alcohol.
3., after reaction finishes, reaction mixture is to room temperature, add concentrated hydrochloric acid with the neutralization reaction catalyzer to reaction mixture pH value in 7 left and right. After methylcarbonate is reclaimed in fractionation, the underpressure distillation aliphatic ether is appropriate.The distillation residuum is cooled to 0-5 ℃, and crystallization, filtration, obtain product 4,5-dimethyl-1,3-dioxole-2-ketone crude product 62.34g.
4. add recrystallization solvent and 0.62g gac in crude product, be heated to 80 ℃ of return stirring 0.5-1h, filtered while hot, filtrate 60 ℃ of lower evaporation concentration to after having mass crystallization to separate out, adopt cooling bath cooling concentration liquid to 0-5 ℃, the gained solids is dried 2h at 50 ℃ of lower normal pressures.
Can obtain highly purified 4,5-Dimethyl-1,3-dioxol-2-one white crystal, these are highly purified 4 years old, 5-dimethyl-1, the quality of 3-dioxole-2-ketone is 53.88g, yield is 47.26% (calculating with the 3-hydroxy-2-butanone), purity (high performance liquid chromatography) is 99.0%, and fusing point is 77-78 ℃.

4,5-Dimethyl-1,3-dioxol-2-one synthesis

Synthesis of 4,5-Dimethyl-1,3-dioxol-2-one from NISTC52217024 and Ethyl chloroformate

4,5-Dimethyl-1,3-dioxol-2-one Preparation Products And Raw materials

Raw materials

NISTC52217024 Carbon dioxide Triphosgene

Preparation Products

4,5-Dimethyl-1,3-dioxol-2-one Suppliers

Global( 432)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Chongqing Ensky Pharmaceutical Co.,Ltd.	+86-23-86815286 +86-13983794297	sales@ensky-chemical.com	China	92	58
Henan Bao Enluo International TradeCo.，LTD	+86-17331933971 +86-17331933971	deasea125996@gmail.com	China	2472	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29791	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	18779	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21634	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29884	58
.GZ HONESTCHEM CO.,LTD	+86-15013270415 +86-15013270415	honestchemical@foxmail.com	China	244	58
Zhejiang ZETian Fine Chemicals Co. LTD	+8618957127338	stella@zetchem.com	China	2136	58
Tianjin Huiren Chemtech Co., Ltd	+86-86-22-23707858 +86-86-13672008665	huirentech@foxmail.com	China	171	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10310	58

Supplier	Advantage
Chongqing Ensky Pharmaceutical Co.,Ltd.	58
Henan Bao Enluo International TradeCo.，LTD	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
.GZ HONESTCHEM CO.,LTD	58
Zhejiang ZETian Fine Chemicals Co. LTD	58
Tianjin Huiren Chemtech Co., Ltd	58
Shenzhen Nexconn Pharmatechs Ltd	58

View Lastest Price from 4,5-Dimethyl-1,3-dioxol-2-one manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-11-22	4,5-Dimethyl-1,3-dioxol-2-one 37830-90-3	US $0.00-0.00 / Kg/Drum	1KG	99.5%min GC	10000kg	WUHAN FORTUNA CHEMICAL CO., LTD
2024-11-21	4,5-Dimethyl-1,3-dioxol-2-one 37830-90-3	US $0.00 / KG	1KG	≥99%	Olmesartan intermediate	Jinan Finer Chemical Co., Ltd
2024-10-24	4,5-Dimethyl-1,3-dioxol-2-one 37830-90-3	US $37600.00-37500.00 / tons	1tons	99%	1000tons	Hebei Dangtong Import and export Co LTD

4,5-Dimethyl-1,3-dioxol-2-one
37830-90-3
US $0.00-0.00 / Kg/Drum
99.5%min GC
WUHAN FORTUNA CHEMICAL CO., LTD

4,5-Dimethyl-1,3-dioxol-2-one
37830-90-3
US $0.00 / KG
≥99%
Jinan Finer Chemical Co., Ltd

4,5-Dimethyl-1,3-dioxol-2-one
37830-90-3
US $37600.00-37500.00 / tons
99%
Hebei Dangtong Import and export Co LTD

4,5-Dimethyl-1,3-dioxol-2-one Spectrum

4,5-Dimethyl-1,3-dioxol-2-one(37830-90-3)MS 4,5-Dimethyl-1,3-dioxol-2-one(37830-90-3)¹HNMR 4,5-Dimethyl-1,3-dioxol-2-one(37830-90-3)¹³CNMR 4,5-Dimethyl-1,3-dioxol-2-one(37830-90-3)IR1 4,5-Dimethyl-1,3-dioxol-2-one(37830-90-3)IR2 4,5-Dimethyl-1,3-dioxol-2-one(37830-90-3)Raman

37830-90-3(4,5-Dimethyl-1,3-dioxol-2-one)Related Search:

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DIMETHYLGLYOXIME DISODIUM SALT 4-Cloromethyl-5-methyl-1,3-dioxol-2-one ETHANE Olmesartan 4-(1-Methoxy-1-methylethyl)-2-propyl-1H-Imidazole-5-carboxylic acid ethyl ester

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4,5-DIMETHYL-1,3-DIOXOL-2-ONE 1,3-DIOXOL-2-ONE, 4,5-DIMETHYL- 4,5-DIMETHYL-1,3-DIOXOLENE-2-ONE (DMDO) 5-Dimethyl-1,3-dioxol-2-one 4,5-Dimethyl-1,3-dioxolen-3-one 4,5-dimethyl-2-oxo-1,3-dioxolene DMDO (4,5-DIMETHYL-1,3-DIOXOL-2-ONE) 4,5-DIMETHYL-1,3-DIOXAL-2-ONE 4,5-DIMETHYL-1,3-DIOXOL-2-ONE (DMDO) 4,5-DIMETHYL-1,3-DIOXOL-2-ONE(OR DIMETHYLDIOXOLONE) 4,5-DIMETHYL-1,3-DIOXOL-2-ONE 99+% 4,5-Dimethyl-1,3-dioxocyclopenten-2-one 4,5-DIMETHYL-1,3-DIOXO-2-ONE 4,5-Dimethyl-1,3-dioxolen-2-one(DDO) Carbonic acid 1,2-dimethylvinylene ester Carbonic acid 2-butene-2,3-diyl ester Dimethyl vinylene carbonate Dimethylvinylene carbonate 4,5-dimethyl-1,3-dioxa-4-cyclopentene-2-one 4,5-Dimethyl-1,3-dio 4,5-Dimethyl-1,3-dioxol-2-one dimethyldioxolone ethyldiox 3-dioxol-2-one diMethyl-2H-1,3-dioxol-2-one 4-5-Methyl-l,3-dioxocyclopenten-2–one 4,5-Dimethyl-1,3-dioxolen-3-one(DMDO) 4,5-dimethyl 1,3-2 oxygen heterocycle pentene-2-ketone 4,5-dimethyl-l,3-dioxolene-2-one (DMDO) 4,5-Dimethyl-1,3-dioxol-2-one USP/EP/BP Olmesartan Dimethyl Impurity Olmesartan DMDO-Cl Impurity Ⅴ 4,5-Dimethyl-1,3-dioxol-2-one> ORDIMETHYLDIOXOLONE Olmesartan DMDO-CL Impurity Ⅱ Olmesartan Medoxomil Impurity 37 AZATMint-A Olmesartan Impurity 54 DIMETHYLDIOXOLONE 4,5-Dimethyl-1,3-dioxolen-2-one DMDO 4,5-Dimethyl-1,3-dioxole-2-one(DMDO) 4.5 Dimethyl 1.3 dioxane 2-one 4,5-Dimethy-1,3-dioxol-2-one(DMDO) 37830-90-3 Pharmaceutical Intermediates Agricultural chemicals(bactericide) Oxygen cyclic compounds Fluorobenzene