NSC305787 (hydrochloride)
- CAS No.
- 53868-26-1
- Chemical Name:
- NSC305787 (hydrochloride)
- Synonyms
- NSC-305787 HCl;NSC305787 (hydrochloride);NSC305787 hydrochloride,NSC-305787 hydrochloride;(2-(Adamantan-1-yl)-6,8-dichloroquinolin-4-yl)(piperidin-2-yl)methanol hydrochloride
- CBNumber:
- CB23121122
- Molecular Formula:
- C25H31Cl3N2O
- Molecular Weight:
- 481.89
- MDL Number:
- MFCD29924224
- MOL File:
- 53868-26-1.mol
NSC305787 (hydrochloride) price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biorbyt Ltd | orb611788 | NSC-305787 hydrochloride | 53868-26-1 | 10mg | $615.4 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb611788 | NSC-305787 hydrochloride | 53868-26-1 | 50mg | $1802 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb611788 | NSC-305787 hydrochloride | 53868-26-1 | 100mg | $2512.6 | 2021-12-16 | Buy |
| Crysdot | CD31001574 | NSC305787hydrochloride 98+% | 53868-26-1 | 50mg | $1042 | 2021-12-16 | Buy |
| DC Chemicals | DC24022 | NSC-305787hydrochloride >98% | 53868-26-1 | 50mg | $1200 | 2021-12-16 | Buy |
NSC305787 (hydrochloride) Chemical Properties,Uses,Production
Biological Activity
NSC305787 (hydrochloride) is an ezrin inhibitor with Kd value of 5.85 μM, inhibits PKCI-induced ezrin phosphorylation, IC50 of 8.3 μM, and has antitumor activity.
in vitro
NSC305787 hydrochloride is an inhibitor of ezrin with a K d of 5.85 μM, and has antitumor activity. It inhibits PKCΙ phosphorylation of Ezrin, Moesin, Radixin, MBP, with IC 50 s of 8.3, 9.4, 55, 58.9 μM, respectively. It binds to PKCΙ with a K d value of 172.4 μM, and inhibits ezrin T567 phosphorylation primarily via its binding to ezrin and not through inhibition of PKCI kinase activity. It (1, 10 μM) shows inhibitory activity against ezrin-mediated invasion of K7M2 osteosarcoma (OS) cells. Moreover, it reduces cell motility phenotypes in zebrafish and blocks OS metastatic growth in lung organ culture.
in vivo
NSC305787 (hydrochloride) suppresses ezrin-dependent osteosarcoma metastatic growth in mouse lung. It dramatically inhibits pulmonary metastasis in a transgenic mouse model of osteosarcoma (Osx -Cre + p53 fl/fl pRB fl/fl ) and shows a more favorable pharmacokinetic profile compared with NSC668394 in the mouse model.
target
Kd: 5.85 μM (ezrin)
IC50: 8.3 μM (ezrin)
NSC305787 (hydrochloride) Preparation Products And Raw materials
Raw materials
Preparation Products
NSC305787 (hydrochloride) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Jilin Chinese Academy of Sciences-yanshen Technology | +undefined18143011203 | info@chemextension.com | China | 42057 | 58 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4863 | 58 |
| Beijing Solarbio Science & Tecnology Co., Ltd. | 010-50973130 4009686088 | 3193328036@qq.com | China | 29786 | 68 |
| Musechem | +1-800-259-7612 | info@musechem.com | United States | 4662 | 60 |
| DC Chemicals | 021-58447131 13564518121 | sales@dcchemicals.com | China | 9412 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| Shanghai Zeye Biotechnology Co., Ltd. | 021-61998551 13122364865 | sale1@shzysw.net | China | 9772 | 58 |
| Absin Bioscience Inc. | 021-38015121 15000105423 | wulan@absin.cn | China | 24734 | 58 |
| Shanghai hongqu biomedical technology co. LTD | 88888888888 | hongquchem@qq.com | China | 5132 | 58 |