RO 15-4513
- CAS No.
- 91917-65-6
- Chemical Name:
- RO 15-4513
- Synonyms
- RO 15-4513;Azidomazenil;Ro15 4513,Ro154513,Ro-15-4513;RO 15-4513 ETHANOL ANTAGONIST;Ethyl-8-azido-5,6-dihydro-5-methyl-6-oxo-4H-imidazo-1,4-benzodiazepine-3-carboxylate;ETHYL 8-AZIDO-6-DIHYDRO-5-METHYL-6-OXO-4H-IMIDAZO[1,5-A]-[1,4]BENZODIAZEPINE-3-CARBOXYLATE;8-Azido-5,6-dihydro-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid ethyl ester;4H-Imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid, 8-azido-5,6-dihydro-6-oxo-, ethyl ester;8-AZIDO-5,6-DIHYDRO-5-METHYL-6-OXO-4H-IMIDAZO[1,5-A][1,4]BENZODIAZEPINE-3-CARBOXYLIC ACID ETHYL ESTER;4H-Imidazo(1,5-A)(1,4)benzodiazepine-3-carboxylic acid, 8-azido-5,6-dihydro-5-methyl-6-oxo-, ethyl ester
- CBNumber:
- CB2312745
- Molecular Formula:
- C15H14N6O3
- Molecular Weight:
- 326.32
- MDL Number:
- MFCD00078598
- MOL File:
- 91917-65-6.mol
- MSDS File:
- SDS
| storage temp. | Desiccate at +4°C |
|---|---|
| solubility | 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.8 mg/mL |
| form | solid |
| color | tan |
| CAS DataBase Reference | 91917-65-6 |
| FDA UNII | S5XGL82O5Y |
RO 15-4513 price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | R109 | Ro 15-4513 solid | 91917-65-6 | 25mg | $502 | 2024-03-01 | Buy |
| Sigma-Aldrich | R109 | Ro 15-4513 solid | 91917-65-6 | 100mg | $1700 | 2024-03-01 | Buy |
| Tocris | 1997 | Ro 15-4513 ≥98%(HPLC) | 91917-65-6 | 50 | $542 | 2021-12-16 | Buy |
| Tocris | 1997 | Ro 15-4513 ≥98%(HPLC) | 91917-65-6 | 10 | $150 | 2021-12-16 | Buy |
| TRC | R700943 | Ro 15-4513 | 91917-65-6 | 1mg | $150 | 2021-12-16 | Buy |
RO 15-4513 Chemical Properties,Uses,Production
Description
Ro 15-4513 is a partial inverse agonist of benzodiazepine receptors. It acts as a competitive antagonist, and can therefore be an antidote to the acute impairment caused by alcohol. Ro 15-4513's Ki values are 3.1 and 5.3 nM for diazepam-insensitive (DI) and diazepam-sensitive (DS) benzodiazepine receptors respectively. Ro 15-4513 displays partial agonism at DI α4- and α6-GABAA receptors.
Chemical Properties
Off-white solid
Uses
Ro 15-4513 is an alcohol antagonist.
Uses
Ro 15-4513 has been used as a benzodiazepine (Bz) inverse agonist in rats and to test its binding with diazepam-sensitive (DS) receptors in in vitro radioligand binding studies.
Application
Ro 15-4513 is benzodiazepine receptor partial inverse agonist. It elicits anxiogenic property and is an ethanol antagonist. It elicits a high affinity towards diazepam sensitive and insensitive sites in the cerebellar region. Ro 15-4513 possesses an imidazo ring and is an imidazobenzodiazepine.
Definition
ChEBI: 8-azido-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid ethyl ester is an organonitrogen heterocyclic compound and an organic heterotricyclic compound.
Biological Activity
High affinity benzodiazepine ligand. K i values are 3.1 and 5.3 nM for diazepam-insensitive (DI) and diazepam-sensitive (DS) benzodiazepine receptors respectively. Acts as partial inverse agonist at recombinant DS α 1-, α 2-, α 3- and α 5-GABA A receptors. Displays partial agonism at DI α 4- and α 6-GABA A receptors. Antagonizes several behavioral and neurochemical effects of ethanol. Proconvulsant and anxiogenic.
Biochem/physiol Actions
Ro 15-4513 is benzodiazepine receptor partial inverse agonist. It elicits anxiogenic property and is an ethanol antagonist. It elicits a high affinity towards diazepam sensitive and insensitive sites in the cerebellar region. Ro 15-4513 possesses an imidazo ring and is an imidazobenzodiazepine.
storage
Desiccate at +4°C
RO 15-4513 Preparation Products And Raw materials
Raw materials
Preparation Products
RO 15-4513 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32165 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38632 | 58 | |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8467 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52925 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15839 | 69 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51456 | 80 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8447 | 60 |
| DC Chemicals | 021-58447131 13564518121 | sales@dcchemicals.com | China | 9409 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11217 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8140 | 58 |
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