ChemicalBook >> CAS DataBase List >>NSC-12
NSC-12
- CAS No.
- 102586-30-1
- Chemical Name:
- NSC-12
- Synonyms
- CS-2338;CS-2161;NSC12，NSC 172285;NSC-12;NSC 12;NSC12;21-Norchol-5-ene-3,20,23-triol, 24,24,24-trifluoro-23-(trifluoromethyl)-, (3β,20S)-
- CBNumber:
- CB23145540
- Molecular Formula:
- C24H34F6O3
- Molecular Weight:
- 484.52
- MDL Number:
- MFCD31544308
- MOL File:
- 102586-30-1.mol
- MSDS File:
- SDS
Last updated:2024-07-02 08:55:03
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H400-H410 | |||||||||
| Precautionary statements | P264-P270-P273-P301+P312-P330-P391-P501 | |||||||||
| NFPA 704 |
|
NSC-12 price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 20117 | NSC 12 ≥98% | 102586-30-1 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 20117 | NSC 12 ≥98% | 102586-30-1 | 5mg | $131 | 2024-03-01 | Buy |
| Cayman Chemical | 20117 | NSC 12 ≥98% | 102586-30-1 | 10mg | $230 | 2024-03-01 | Buy |
| Cayman Chemical | 20117 | NSC 12 ≥98% | 102586-30-1 | 25mg | $494 | 2024-03-01 | Buy |
| DC Chemicals | DC9945 | NSC-12 >98% | 102586-30-1 | 250mg | $1750 | 2021-12-16 | Buy |
NSC-12 Chemical Properties,Uses,Production
Biological Activity
NSC12 (NSC 172285) is an orally available inhibitor of FGF2/FGFR interaction with potential antitumor activity.
in vitro
NSC-12 can inhibit FGF-dependent tumor growth, angiogenesis and metastasis. It did not affect FGF2/heparin interaction, but inhibited FGF2 binding to immobilized receptors (IC50 ~30 μM), it disrupted FGF2 interaction with FGFR1, and had no effect on the interaction activity of growth factors with heparin or HSPGs .
in vivo
Administered by injection and oral route, NSC-12 inhibits FGFR activation, tumor growth, angiogenesis and metastasis in FGF-dependent mouse and human tumor models. In animal models, it significantly reduced tumor weight, tumor cell FGFR1 phosphorylation levels and proliferation, and tumor CD31+ cardiovascular formation.
target
| Target | Value |
| FGF3 (Cell-free assay) | 15.9 μM(Kd) |
| FGF8b (Cell-free assay) | 18.9 μM(Kd) |
| FGF22 (Cell-free assay) | 26.8 μM(Kd) |
| FGF20 (Cell-free assay) | 29.4 μM(Kd) |
| FGF2/FGFR (Cell-free assay) | 30 μM |
NSC-12 Preparation Products And Raw materials
Raw materials
Preparation Products
NSC-12 Suppliers
Global( 37)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8467 | 58 |
| Nanjing Bicbiotechnology Co., Ltd | +86-2552131256 +86-18251840740 | sales@bicbiotech.com | China | 5994 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57505 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2922 | 55 | |
| Dalian Meilun Biotech Co., Ltd. | 0411-62910999 13889544652 | meilunui@163.com | China | 4727 | 58 |
| Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7887 | 56 |
| Shanghaizehan biopharma technology co., Ltd. | 021-61350663 13052117465 | sales@zehanbiopharma.com | China | 1009 | 55 |
| Shanghai Biopharmaleader Co., Ltd. | +86 18721201413 | sales@biopharmaleader.com | China | 1720 | 58 |
NSC-12;NSC 12;NSC12
CS-2161
CS-2338
21-Norchol-5-ene-3,20,23-triol, 24,24,24-trifluoro-23-(trifluoromethyl)-, (3β,20S)-
NSC12，NSC 172285
102586-30-1
C24H34F6O3