TCS-3035
- CAS No.
- 871085-49-3
- Chemical Name:
- TCS-3035
- Synonyms
- TCS-3035;2-[4-[(Z)-(2,4-Dioxo-5-thiazolidinylidene)methyl]phenoxyacetic acid;(Z)-2-(4-((2,4-dioxothiazolidin-5-ylidene)methyl)phenoxy)acetic acid;Acetic acid, 2-[4-[(Z)-(2,4-dioxo-5-thiazolidinylidene)methyl]phenoxy]-
- CBNumber:
- CB23152991
- Molecular Formula:
- C12H9NO5S
- Molecular Weight:
- 279.27
- MDL Number:
- MFCD01835940
- MOL File:
- 871085-49-3.mol
TCS-3035 price More Price(6)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Tocris | 4244 | TCS3035 ≥98%(HPLC) | 871085-49-3 | 10 | $141 | 2021-12-16 | Buy |
Tocris | 4244 | TCS3035 ≥98%(HPLC) | 871085-49-3 | 50 | $573 | 2021-12-16 | Buy |
TRC | T127285 | TCS3035 | 871085-49-3 | 50mg | $795 | 2021-12-16 | Buy |
Usbiological | 256879 | TCS 3035 | 871085-49-3 | 10mg | $460 | 2021-12-16 | Buy |
ApexBio Technology | B7783 | TCS3035 | 871085-49-3 | 50mg | $1253 | 2021-12-16 | Buy |
TCS-3035 Chemical Properties,Uses,Production
Uses
TCS 3035 is a potent and selective GPR35 agonist.
Biological Activity
tcs3035, a gpr35 agonist, shows significantly high potency at rat and human gpr35 orthologs with pec50 values of 5.13 and 5.86, respectively [1]. g protein-coupled receptors (gpcrs) are the largest and most studied group of transmembrane polypeptides. gpr35 is a poorly characterized g protein-coupled receptor that plays an important role in immune-modulation, gastric function and the regulation of insulin secretion. gpr35 is predominantly expressed in the gastro-intestinal tract and immune tissues. the tryptophan metabolite kynurenic acid has been suggested to be the endogenous ligand for gpr35 [1].
in vitro
mutation to alanine of the conserved arginine at position 3.36 in either flag-hgpr35-eyfp or flag-rgpr35-eyfp resulted in a complete loss of agonist function of tcs3035 [1]. in addition, tcs3035-induced internalization of gpr35 is correlated with tcs3035 potency in receptor-β-arrestin-2 interaction bret assays. mutation to alanine of tyrosine 3.32 in transmembrane domain iii abolished β-arrestin-2 recruitment in response to tcs3035 [1].
target
gpr35
storage
Store at +4°C
References
1. jenkins l, alvarez-curto e, campbell k, de munnik s, canals m, schlyer s, et al. agonist activation of the g protein-coupled receptor gpr35 involves transmembrane domain iii and is transduced via galpha(1)(3) and beta-arrestin-2. br j pharmacol. 2011;162(3):733-48.
TCS-3035 Preparation Products And Raw materials
Raw materials
Preparation Products
TCS-3035 Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 23963 | 58 |
United States Biological | -- | sales@advtechind.com | United States | 6106 | 58 |
ApexBio Technology | -- | sales@apexbt.com | United States | 6254 | 58 |
Supplier | Advantage |
---|---|
Aladdin Scientific | 58 |
BOC Sciences | 65 |
TargetMol Chemicals Inc. | 58 |
United States Biological | 58 |
ApexBio Technology | 58 |