ISA-2011B
- CAS No.
- 1395347-24-6
- Chemical Name:
- ISA-2011B
- Synonyms
- ISA-2011B;ISA2011B; ISA 2011B;ISA-2011B,Inhibitor,inhibit,ISA 2011B,ISA2011B;5H-1,3-Dioxolo[4,5-g]pyrazino[1,2-b]isoquinoline-7,10-dione, 5-(5-chloro-1H-indol-3-yl)-8,9,10a,11-tetrahydro-9-methyl-, (5S,10aS)-
- CBNumber:
- CB23167641
- Molecular Formula:
- C22H18ClN3O4
- Molecular Weight:
- 423.85
- MDL Number:
- MFCD30533398
- MOL File:
- 1395347-24-6.mol
ISA-2011B price
ISA-2011B Chemical Properties,Uses,Production
Biological Activity
ISA-2011B is an inhibitor of PIP5K1α with anticancer activity.
in vitro
The proliferation rate of PC-3 cells after treatment with ISA-2011B at 10, 20, and 50 μM is significantly reduced to 58.77%, 48.65%, and 21.62% of vehicle-treated controls, respectively. It exhibits the highest binding affinity to PIP5K1α, and to MAP/microtubule affinity-regulating kinase 1 and 4 (MARK1 and MARK4) across 460 kinases. It treatment inhibits PIP5K1α expression by 78.6% in PC-3 cells. It leads to a remarkable reduction in AR-V7 and CDK1 in both nucleus and cytoplasm of 22Rv1 cells. It treatment also abolishes AR expression in the nucleus, without depleting the cytoplasmic AR.
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in vivo
ISA-2011B significantly inhibits growth of tumor cells in xenograft mice, and is mediated by targeting PIP5K1α-associated PI3K/AKT and the downstream survival, proliferation, and invasion pathways. Overexpression of AR-V7 increases PIP5K1α, promotes rapid growth of PCa in xenograft mice, whereas inhibition of PIP5K1α by its inhibitor. It suppresses the growth and invasiveness of xenograft tumors overexpressing AR-V7.It disrupts protein stabilization of AR-V7 which is dependent on PIP5K1α, leading to suppression of invasive growth of AR-V7-high tumors in xenograft mice.
ISA-2011B Preparation Products And Raw materials
Raw materials
Preparation Products
ISA-2011B Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Jilin Chinese Academy of Sciences-yanshen Technology | +undefined18143011203 | info@chemextension.com | China | 42057 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9806 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 27314 | 60 |
| Shanghai Han-Xiang Chemical Co., Ltd. | 15971444841 | amber@biochempartner.com | China | 3063 | 58 |
| DC Chemicals | 021-58447131 13564518121 | sales@dcchemicals.com | China | 9412 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| Shanghai Zeye Biotechnology Co., Ltd. | 021-61998551 13122364865 | sale1@shzysw.net | China | 9772 | 58 |
| Shanghai hongqu biomedical technology co. LTD | 88888888888 | hongquchem@qq.com | China | 5132 | 58 |