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4-Hydroxy-4'-isopropoxydiphenylsulfone

4-Hydroxy-4'-isopropoxydiphenylsulfone structure

CAS No.: 95235-30-6

Chemical Name:: 4-Hydroxy-4'-isopropoxydiphenylsulfone

Synonyms: BPS-monoP;UBA7;UBE2;D-8.;UBE1L;UBA1B;D8(HPS);MGC12713;WinCon-8;F-108(D-8)

CBNumber:: CB2324449

Molecular Formula:: C15H16O4S

Molecular Weight:: 292.35

MDL Number:: MFCD01861244

MOL File:: 95235-30-6.mol

Last updated:2024-12-18 14:08:52

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4-Hydroxy-4'-isopropoxydiphenylsulfone Properties

Melting point	129 °C
Boiling point	478.8±30.0 °C(Predicted)
Density	1.251±0.06 g/cm3(Predicted)
vapor pressure	0Pa at 27℃
storage temp.	Sealed in dry,Room Temperature
solubility	0.891 in mg/100g standard fat at 20 ℃
form	powder to crystal
pka	7.24±0.15(Predicted)
color	White to Almost white
Water Solubility	19.7mg/L at 25℃
InChI	InChI=1S/C15H16O4S/c1-11(2)19-13-5-9-15(10-6-13)20(17,18)14-7-3-12(16)4-8-14/h3-11,16H,1-2H3
InChIKey	ZTILAOCGFRDHBH-UHFFFAOYSA-N
SMILES	C1(O)=CC=C(S(C2=CC=C(OC(C)C)C=C2)(=O)=O)C=C1
LogP	3.36 at 25℃
CAS DataBase Reference	95235-30-6(CAS DataBase Reference)
EWG's Food Scores	1
EPA Substance Registry System	Phenol, 4-[[4-(1-methylethoxy)phenyl]sulfonyl]- (95235-30-6)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS09
Hazard statements	H411
Hazard Codes	N
Risk Statements	51/53
Safety Statements	61
HS Code	2930.90.2900

4-Hydroxy-4'-isopropoxydiphenylsulfone price More Price(20)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	SAB5300007	Monoclonal Anti-UBA7 antibody produced in mouse clone 5B10, ascites fluid	95235-30-6	100μL	$503	2023-01-07	Buy
Sigma-Aldrich	SAB1307068	ANTI-UBA7(N-TERMINAL) antibody produced in rabbit affinity isolated antibody, buffered aqueous solution	95235-30-6	400μL	$461	2023-01-07	Buy
TCI Chemical	I1045	4-[(4-Isopropoxyphenyl)sulfonyl]phenol	95235-30-6	5G	$59	2024-03-01	Buy
TCI Chemical	I1045	4-[(4-Isopropoxyphenyl)sulfonyl]phenol	95235-30-6	25G	$203	2024-03-01	Buy
Usbiological	134984	UBA7	95235-30-6	50ug	$539	2021-12-16	Buy

Product number	Packaging	Price	Buy
SAB5300007	100μL	$503	Buy
SAB1307068	400μL	$461	Buy
I1045	5G	$59	Buy
I1045	25G	$203	Buy
134984	50ug	$539	Buy

4-Hydroxy-4'-isopropoxydiphenylsulfone Chemical Properties,Uses,Production

Uses

For color developing dyes, various types of dye such as fluoran, phthalide, lactam, triphenylmethane, spiropyran and other types of leuco dyes can be used, but usable dyes are not limited to these only. Besides, these color developing dyes can be mixed in different combinations.

Flammability and Explosibility

Not classified

Safety

4-Hydroxy-4′-isopropoxydiphenylsulfone (BPSIP), a novel alternative to BPA, is frequently detected in breast milk and the placental barrier system, suggesting that it may be transmitted from mother to offspring and increase the risk of exposure. In a study of the behavioral and neurobiological effects of early-life exposure to BPSIP (0.02, 0.1, and 0.5 mg/kg body weight/day) in mouse offspring, BPSIP exposure induced ASD-like behaviors in male and female pups, including increased anxiety-related behaviors and decreased spatial memory. A clear pattern of decreased social novelty was observed only in female offspring, accompanied by significant changes in antioxidant levels. In addition, decreased protein levels of complex IV (COX IV) in all tested populations suggest a significant impact on mitochondrial function, which may contribute to abnormal energy metabolism in autism. Changes in synaptic proteins, as evidenced by altered levels of synapsin 1 (SYN1) and postsynaptic density protein 95 (PSD95) in the cerebellum and hippocampus, support the idea of synaptic involvement. These findings suggest that BPSIP may induce sex-specific neurotoxic effects involving oxidative stress, energy production, and synaptic plasticity^[1].

Synthesis

30.3 g of bis(p-hydroxyphenyl)sulfone, 18.5 g of isopropylbromide, and 22.2 g of potassium carbonate as acid-binding agent were added to 200 ml of dimethylformamide, then stirred for 4 hours at about 120° C. and dimethylformamide was distilled off under reduced pressure. When this was accomplished, chloroform was added to the residue to extract crude 4-hydroxy-4'-isopropoxydiphenylsulfone. Then this crude compound was refined by using a silica gel column chromatography and 15.7 g of 4-hydroxy-4'-isopropoxydiphenylsulfone was obtained in white microfine crystals with a melting point of 129.0°~131.0° C.

References

[1] SHENGNAN ZHANG. Early-Life Exposure to 4-Hydroxy-4’-Isopropoxydiphenylsulfone Induces Behavioral Deficits Associated with Autism Spectrum Disorders in Mice.[J]. 环境科学与技术, 2024: 15984-15996. DOI:10.1021/acs.est.4c04760.

4-Hydroxy-4'-isopropoxydiphenylsulfone Preparation Products And Raw materials

Raw materials

Preparation Products

4-Hydroxy-4'-isopropoxydiphenylsulfone Suppliers

Global( 219)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Dalian Richfortune Chemicals Co., Ltd	0411-84820922 8613904096939	sales@richfortunechem.com	China	304	57
CD Chemical Group Limited	+8615986615575	info@codchem.com	China	20342	58
Wuhan ShuEr Biology Technology Co.,Ltd	+86-15629032529	excellentsuppliers@shuerbio.com	China	897	58
Changzhou waston chemical technology Co.,Ltd	+86-051985861892 +8618112881323	info@wastonchem.com	China	260	58
Weifang Dayoo Biochemical Co., Ltd.,	+undefined13305362020	sales@dayoochemical.com	China	20	58
Hebei Yanxi Chemical Co., Ltd.	+8617531190177	peter@yan-xi.com	China	5857	58
Hebei Weibang Biotechnology Co., Ltd	+8617732866630	bess@weibangbio.com	China	18151	58
Hebei Zhuanglai Chemical Trading Co Ltd	+86-16264648883 +86-16264648883	niki@zlchemi.com	China	3001	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29791	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	18751	58

Supplier	Advantage
Dalian Richfortune Chemicals Co., Ltd	57
CD Chemical Group Limited	58
Wuhan ShuEr Biology Technology Co.,Ltd	58
Changzhou waston chemical technology Co.,Ltd	58
Weifang Dayoo Biochemical Co., Ltd.,	58
Hebei Yanxi Chemical Co., Ltd.	58
Hebei Weibang Biotechnology Co., Ltd	58
Hebei Zhuanglai Chemical Trading Co Ltd	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58

View Lastest Price from 4-Hydroxy-4'-isopropoxydiphenylsulfone manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-12-27	4-Hydroxy-4'-isopropoxydiphenylsulfone 95235-30-6	US $10.00 / kg	1kg	99%	20 ton	Hebei Zhuanglai Chemical Trading Co Ltd
2024-12-26	4-Hydroxy-4'-isopropoxydiphenylsulfone 95235-30-6	US $0.00 / Kg/Drum	1KG	99%	100mt/year	Jinan Finer Chemical Co., Ltd
2024-11-05	4-Hydroxy-4'-isopropoxydiphenylsulfone 95235-30-6	US $0.00-0.00 / KG	1KG	99%	500000kg	Hebei Weibang Biotechnology Co., Ltd

4-Hydroxy-4'-isopropoxydiphenylsulfone
95235-30-6
US $10.00 / kg
99%
Hebei Zhuanglai Chemical Trading Co Ltd

4-Hydroxy-4'-isopropoxydiphenylsulfone
95235-30-6
US $0.00 / Kg/Drum
99%
Jinan Finer Chemical Co., Ltd

4-Hydroxy-4'-isopropoxydiphenylsulfone
95235-30-6
US $0.00-0.00 / KG
99%
Hebei Weibang Biotechnology Co., Ltd

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P-(METHYLTHIO)ISOBUTYROPHENONE 4-Hydroxy-4'-isopropoxydiphenylsulfone

1of4

WinCon-8 (4-Hydroxy-4'-Isopropoxydiphenylsulfon 4-Hydroxy-4'-isoprop 4-hydroxy-4-Isopropoxydiphenylsulfone (D-8) Anti-UBE1L, C-Terminal antibody produced in rabbit Ubiquitin-activating enzyme 7 Ubiquitin-activating enzyme E1 homolog ANTI-UBA7(N-TERMINAL) antibody produced in rabbit UBA7 UBE1L UBE2 Ubiquitin-like modifier-activating enzyme 7 MGC12713 Monoclonal Anti-UBA7 antibody produced in mouse UBA1B 4-HYDROXY-4'-ISOPROPOXYDIPHENYLSULFONE 4-HYDROXY-4-ISOPROPOXYDIPHENYLSULFONE 4-ISOPROPOXYPHENYL-4'-HYDROXYPHENYL SULFONE 4-ISOPROPYLOXYPHENYL-4'-HYDROXYPHENYLSULFONE D-8 DEVELOPER D8(HPS) 4-hydroxy-4'-isopropoxydiphenylsulphone 4-hydroxy-4'-isopropoxydiphenylsulfone(D-8) developer D8(HPS)4-ISOPROPYLOXYPHENYL-4'-HYDROXYPHENYLSULFONE 4-Hydroxy-4'-IsopropoxydiphenylsulfonedeveloperD-8 D-8. 4-HYDROXY-4'' -CISOPROPOXYDIPHENYLSULFONE 4-(4-Isopropoxyphenylsulfonyl)phenol Phenol,4-[[4-(1-methylethoxy)phenyl]sulfonyl]- 4-[[4-(1-Methylethoxy)phenyl]sulfonyl]phenol 4-Hydroxyphenyl 4-isopropoxyphenyl sulfone 4-(4-Isopropoxyp 4-HYDROXY-4''-ISOPROPOXYDIPHENYLSULFONE(D-8) DEVELOPER 99% 4-Hydroxy-4'-isopropoxydiphenylsulfone 95235-30-6 WinCon-8 DL-Homocystine-3,3,3&rsquo 4,4,4&rsquo F-108(D-8) 4-Hydroxy-4-isopropoxydiphenylsulfone 99% 4-(4-propan-2-yloxyphenyl)sulfonylphenol UBE1L (Ubiquitin-like modifier-activating enzyme 7 BPS-monoP D8/4-hydroxy-4 '- isopropoxydiphenylsulfone/thermosensitive dye D-8 4-Hydroxy-4'-isopropoxydiphenylsulfone 4-Hydroxy-4'-isopropoxydiphenylsulfone(D8) Thermal paper developer D8 4-Isopropyloxyphenyl-4'-Hydroxyphenylsulfone 4-[(4-Isopropoxyphenyl)sulfonyl]phenol （D8 ) 95235-30-6 85235-80-6 85235-80-6 95235-30-3 C15H16SO4