PKM2 inhibitor
- CAS No.
- 94164-88-2
- Chemical Name:
- PKM2 inhibitor
- Synonyms
- PKM2-IN-1;compound 3k;PKM2 inhibitor;PKM2 inhibitor 1;PKM2-IN-1;COMPOUND 3K;PKM2-IN-1, 10 mM in DMSO;PKM2 inhibitor(compound 3k);Pyruvate Kinase,inhibit,PKM2 IN 1,Inhibitor,PKM2IN1,PKM-2-IN-1;(3-Methyl-1,4-dioxo-1,4-dihydronaphthalen-2-yl)methyl piperidine-1-carbodithioate;piperidine-1-carbodithioic acid 3-methyl-1,4-dioxo-1,4-dihydronaphthalen-2-ylmethyl ester
- CBNumber:
- CB23350586
- Molecular Formula:
- C18H19NO2S2
- Molecular Weight:
- 345.48
- MDL Number:
- MFCD31619244
- MOL File:
- 94164-88-2.mol
| Boiling point | 496.5±55.0 °C(Predicted) |
|---|---|
| Density | 1.302±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | DMF: 1 mg/ml; DMSO: insol; Ethanol: insol; PBS (pH 7.2): insol |
| form | A solid |
| pka | 0.81±0.20(Predicted) |
| color | Light yellow to yellow |
| UNSPSC Code | 12352200 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| NFPA 704 |
|
PKM2 inhibitor price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | P571505 | PKM2-IN-1 | 94164-88-2 | 5mg | $215 | 2021-12-16 | Buy |
| ChemScene | CS-8094 | PKM2-IN-1 96.55% | 94164-88-2 | 5mg | $96 | 2021-12-16 | Buy |
| ChemScene | CS-8094 | PKM2-IN-1 96.55% | 94164-88-2 | 10mg | $144 | 2021-12-16 | Buy |
| AK Scientific | 2010EL | PKM2inhibitor | 94164-88-2 | 250mg | $205 | 2021-12-16 | Buy |
| ChemScene | CS-8094 | PKM2-IN-1 96.55% | 94164-88-2 | 50mg | $504 | 2021-12-16 | Buy |
PKM2 inhibitor Chemical Properties,Uses,Production
Uses
PKM2-IN-1, is a pyruvate kinase M2 (PKM2) inhibitor with an IC50 of 2.95 μM.
Biological Activity
Pyruvate kinase M2 (PKM2) inhibitor superior to shikonin.
Compound 3k (C3k) is a pyruvate kinase M2 (PKM2) inhibitor with 3-fold higher potency than shikonin (IC50 = 2.95 and 8.82 μM, respectively, by in vitro PKM2 LDH coupled assay). C3k exhibits potent cancer cell-selective antiproliferative activity in high PKM2-expressing cancer cultures (HCT116/HeLA/H1299 IC50 = 0.18/0.29/1.56 μM with C3k, 1.84/2.45/1.88 μM with shikonin) with much less cytotoxicity toward normal BEAS-2B human bronchial epithelial cells (IC50 = 18.46 μM; IC50 = 5.36 μM with shikonin).
PKM2 inhibitor Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32159 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3135 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38630 | 58 | |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43340 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2922 | 55 | |
| Dalian Meilun Biotech Co., Ltd. | 0411-62910999 13889544652 | sales@meilune.com | China | 4728 | 58 |
