nalanthalide
- CAS No.
- 145603-76-5
- Chemical Name:
- nalanthalide
- Synonyms
- nalanthalide;3-[[(1R,4aR,5S,6S,8aR)-6-(acetyloxy)decahydro-5,8a-dimethyl-2-methylene-5-(4-methyl-3-penten-1-yl)-1-naphthalenyl]methyl]-2-methoxy-5,6-dimethyl-4H-pyran-4-one;4H-Pyran-4-one, 3-[[(1R,4aR,5S,6S,8aR)-6-(acetyloxy)decahydro-5,8a-dimethyl-2-methylene-5-(4-methyl-3-penten-1-yl)-1-naphthalenyl]methyl]-2-methoxy-5,6-dimethyl-
- CBNumber:
- CB23351644
- Molecular Formula:
- C30H44O5
- Molecular Weight:
- 484.67
- MDL Number:
- MOL File:
- 145603-76-5.mol
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nalanthalide Chemical Properties,Uses,Production
Description
Nalanthalide is a diterpenoid pyrone fungal metabolite that has been found in Nalanthamala and has potassium channel inhibitory and antiviral activities. It inhibits binding of the potassium channel inhibitor charybdotoxin to Jurkat cell membranes (IC50 = 3 μM) and inhibits rubidium efflux from CHO cells expressing the voltage-gated potassium (Kv) channel Kv1.3 (IC50 = 3.9 μM). Nalanthalide depolarizes T cells in vitro with an EC50 value of 500 nM. It also inhibits HIV-1 integrase activity with IC50 values of 10 and 25 μM in coupled and strand transfer assays, respectively.
Definition
ChEBI: Nalanthalide is a pyranone diterpenoid isolated from Nalanthamala and Chaunopycnis alba and has been shown to be a blocker of the voltage-gated potassium channel Kv1.3 It has a role as a metabolite and a potassium channel blocker. It is a diterpenoid, an enol ether, an ortho-fused bicyclic hydrocarbon, an acetate ester, a member of 4-pyranones and a ketene acetal.
nalanthalide Preparation Products And Raw materials
Raw materials
Preparation Products
nalanthalide Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11975 | 58 |
| Guangzhou Yaoguang Technology Co., Ltd. | 13020159086 | yangjue@ygfuture.com | China | 617 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 19696 | 58 |