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ChemicalBook >> CAS DataBase List >>(R)-5,7-difluorochroman-4-ol

(R)-5,7-difluorochroman-4-ol

(R)-5,7-difluorochroman-4-ol Structure
(R)-5,7-difluorochroman-4-ol structure
CAS No.
1270294-05-7
Chemical Name:
(R)-5,7-difluorochroman-4-ol
Synonyms
(4R)-5,7-difluoro-3,4-dihydro-2H-1-benzopyran-4-ol;Tegoprazan Impurity 11;R-5,7-difluorobenzo dihydropyran-4-ol;Tegoprazan side chain;(R)-5, 7-difluorobenzopyrane-4-ol;2H-1-Benzopyran-4-ol, 5,7-difluoro-3,4-dihydro-, (4R)-;[2-(2-chlorophenyl)ethanamine, 1-Amino-2-(2-chlorophenyl)ethane, 2-(2-Chlorophenyl)ethylamine]
CBNumber:
CB23354564
Molecular Formula:
C9H8F2O2
Molecular Weight:
186.16
MDL Number:
MFCD09763634
MOL File:
1270294-05-7.mol
Last updated:2024-04-15 18:41:30
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(R)-5,7-difluorochroman-4-ol Properties

Boiling point 228.4±40.0 °C(Predicted)
Density 1.402±0.06 g/cm3(Predicted)
pka 13.09±0.20(Predicted)
InChI InChI=1S/C9H8F2O2/c10-5-3-6(11)9-7(12)1-2-13-8(9)4-5/h3-4,7,12H,1-2H2/t7-/m1/s1
InChIKey HGTYMLFMXKYIQW-SSDOTTSWSA-N
SMILES C1OC2=CC(F)=CC(F)=C2[C@H](O)C1

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

(R)-5,7-difluorochroman-4-ol Chemical Properties,Uses,Production

Uses

(R)-5,7-difluorochroman-4-ol is an important intermediate in the synthesis of tegoprazan[1].

Production Methods

Preparing (R)-5,7-difluorochroman-4-ol involves taking 5, 7-difluorochroman-4-one as substrate and performing asymmetric reduction reaction in the presence of ketoreductase, coenzyme and coenzyme circulating system to obtain (R)-5,7-difluorochroman-4-ol, where ketoreductase is one or combination of two or more of short-chain dehydrogenases/reductases family (SDR), medium-chain dehydrogenases/reductase (MDR) or aldo-Keto reductase (AKR)[1].

References

[1]PAN X, et al. "Preparing (R)-5,7-difluorochroman-4-ol involves taking 5, 7-difluorochroman-4-one as substrate, and performing asymmetric reduction reaction in the presence of ketoreductase, coenzyme and coenzyme circulating system to obtain (R)-5,7-difluorochroman-4-ol.", CN202210486605.0. 2022.

(R)-5,7-difluorochroman-4-ol Preparation Products And Raw materials

Raw materials

1-BROMO-4-CHLORO-1,1,2,2-TETRAFLUOROBUTANE 5,7-difluorochroman-4-one

Preparation Products

(R)-5,7-difluorochroman-4-ol Suppliers

Global( 103)Suppliers
Supplier Tel Email Country ProdList Advantage
Hangzhou ICH Biofarm Co., Ltd
+86-0571-28186870; +undefined8613073685410 sales@ichemie.com China 985 58
Zhengzhou Anbu Chem Co.,Ltd 		+86-0371-88006763; +8615988602810 sales@anbuchem.com China 3000 58
Zibo Hangyu Biotechnology Development Co., Ltd 		+86-0533-2185556 +8617865335152 Mandy@hangyubiotech.com China 11013 58
Shanghai Daken Advanced Materials Co.,Ltd 		+86-371-66670886 info@dakenam.com China 16233 58
Shenzhen Nexconn Pharmatechs Ltd 		+86-755-89396905 +86-15013857715 admin@nexconn.com China 10247 58
SHANGHAI T&W PHARMACEUTICAL CO., LTD. 		+86-021-61551413 +8618813727289 contact@trustwe.com China 5738 58
Zhengzhou Alfa Chemical Co.,Ltd 		+8618530059196 sale04@alfachem.cn China 12855 58
Hangzhou Huarong Pharm Co., Ltd. 		571-86758373 +8613588754946 sales@huarongpharm.com CHINA 3149 58
ChemExpress 		+86-021-58950125 info@chemexpress.com China 566 58
Joyochem Co.,Ltd 		+86-0531-82687558 +8613290333633 sales@joyochem.com China 41 58
Supplier Advantage
Hangzhou ICH Biofarm Co., Ltd
58
Zhengzhou Anbu Chem Co.,Ltd 		58
Zibo Hangyu Biotechnology Development Co., Ltd 		58
Shanghai Daken Advanced Materials Co.,Ltd 		58
Shenzhen Nexconn Pharmatechs Ltd 		58
SHANGHAI T&W PHARMACEUTICAL CO., LTD. 		58
Zhengzhou Alfa Chemical Co.,Ltd 		58
Hangzhou Huarong Pharm Co., Ltd. 		58
ChemExpress 		58
Joyochem Co.,Ltd 		58

View Lastest Price from (R)-5,7-difluorochroman-4-ol manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
(R)-5,7-difluorochroman-4-ol pictures 2024-05-21 (R)-5,7-difluorochroman-4-ol
1270294-05-7
 US $0.00 / kg 1kg 98% 200kg Shanghai Joiny Pharmaceutical Co.,LTD
(R)-5,7-difluorochroman-4-ol pictures 2024-05-10 (R)-5,7-difluorochroman-4-ol
1270294-05-7
 US $0.10-0.10 / kg 0.005kg 99.99% 20 tons Zibo Hangyu Biotechnology Development Co., Ltd
(R)-5,7-difluorochroman-4-ol pictures 2023-11-01 (R)-5,7-difluorochroman-4-ol
1270294-05-7
 US $0.00-0.00 / kg 0.1kg 99.0%min 2000kg Hangzhou ICH Biofarm Co., Ltd

1270294-05-7((R)-5,7-difluorochroman-4-ol)Related Search:

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2-Aminobiphenyl 1-(piperidine-4-carbonyl)piperidine-4-carboxylic acid hydrochloride Butanedioic acid, 2-[[2-methyl-1-(phenylmethyl)-1H-imidazol-5-yl]methylene]-, 1-ethyl ester, (2E)- 1H-Benzimidazole-6-carboxamide, 4-hydroxy-N,N,2-trimethyl-1-(phenylmethyl)- Benzoic acid, 4-[[4-(aminocarbonyl)-1-piperidinyl]methyl]-
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1of3

2H-1-Benzopyran-4-ol, 5,7-difluoro-3,4-dihydro-, (4R)- Tegoprazan Impurity 11 R-5,7-difluorobenzo dihydropyran-4-ol (4R)-5,7-difluoro-3,4-dihydro-2H-1-benzopyran-4-ol [2-(2-chlorophenyl)ethanamine, 1-Amino-2-(2-chlorophenyl)ethane, 2-(2-Chlorophenyl)ethylamine] (R)-5, 7-difluorobenzopyrane-4-ol Tegoprazan side chain 1270294-05-7 API