(R)-5,7-difluorochroman-4-ol
- CAS No.
- 1270294-05-7
- Chemical Name:
- (R)-5,7-difluorochroman-4-ol
- Synonyms
- (4R)-5,7-difluoro-3,4-dihydro-2H-1-benzopyran-4-ol;Tegoprazan Impurity 11;R-5,7-difluorobenzo dihydropyran-4-ol;Tegoprazan side chain;(R)-5, 7-difluorobenzopyrane-4-ol;2H-1-Benzopyran-4-ol, 5,7-difluoro-3,4-dihydro-, (4R)-;[2-(2-chlorophenyl)ethanamine, 1-Amino-2-(2-chlorophenyl)ethane, 2-(2-Chlorophenyl)ethylamine]
- CBNumber:
- CB23354564
- Molecular Formula:
- C9H8F2O2
- Molecular Weight:
- 186.16
- MDL Number:
- MFCD09763634
- MOL File:
- 1270294-05-7.mol
Boiling point | 228.4±40.0 °C(Predicted) |
---|---|
Density | 1.402±0.06 g/cm3(Predicted) |
pka | 13.09±0.20(Predicted) |
InChI | InChI=1S/C9H8F2O2/c10-5-3-6(11)9-7(12)1-2-13-8(9)4-5/h3-4,7,12H,1-2H2/t7-/m1/s1 |
InChIKey | HGTYMLFMXKYIQW-SSDOTTSWSA-N |
SMILES | C1OC2=CC(F)=CC(F)=C2[C@H](O)C1 |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H302-H315-H319-H335 |
Precautionary statements | P261-P305+P351+P338 |
(R)-5,7-difluorochroman-4-ol Chemical Properties,Uses,Production
Uses
(R)-5,7-difluorochroman-4-ol is an important intermediate in the synthesis of tegoprazan[1].
Production Methods
Preparing (R)-5,7-difluorochroman-4-ol involves taking 5, 7-difluorochroman-4-one as substrate and performing asymmetric reduction reaction in the presence of ketoreductase, coenzyme and coenzyme circulating system to obtain (R)-5,7-difluorochroman-4-ol, where ketoreductase is one or combination of two or more of short-chain dehydrogenases/reductases family (SDR), medium-chain dehydrogenases/reductase (MDR) or aldo-Keto reductase (AKR)[1].
References
[1]PAN X, et al. "Preparing (R)-5,7-difluorochroman-4-ol involves taking 5, 7-difluorochroman-4-one as substrate, and performing asymmetric reduction reaction in the presence of ketoreductase, coenzyme and coenzyme circulating system to obtain (R)-5,7-difluorochroman-4-ol.", CN202210486605.0. 2022.
(R)-5,7-difluorochroman-4-ol Preparation Products And Raw materials
Raw materials
Preparation Products
(R)-5,7-difluorochroman-4-ol Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Hangzhou ICH Biofarm Co., Ltd | +86-0571-28186870; +undefined8613073685410 | sales@ichemie.com | China | 985 | 58 |
Zhengzhou Anbu Chem Co.,Ltd | +86-0371-88006763; +8615988602810 | sales@anbuchem.com | China | 3000 | 58 |
Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | Mandy@hangyubiotech.com | China | 11012 | 58 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 16221 | 58 |
Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10259 | 58 |
SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5738 | 58 |
Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | sale04@alfachem.cn | China | 12878 | 58 |
Hangzhou Huarong Pharm Co., Ltd. | 571-86758373 +8613588754946 | sales@huarongpharm.com | CHINA | 3149 | 58 |
ChemExpress | +86-021-58950125 | info@chemexpress.com | China | 595 | 58 |
Joyochem Co.,Ltd | +86-0531-82687558 +8613290333633 | sales@joyochem.com | China | 41 | 58 |
View Lastest Price from (R)-5,7-difluorochroman-4-ol manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-06-14 | (R)-5,7-difluorochroman-4-ol
1270294-05-7
|
US $0.00 / kg | 1kg | 98% | 200kg | Shanghai Joiny Pharmaceutical Co.,LTD | ||
2024-05-10 | (R)-5,7-difluorochroman-4-ol
1270294-05-7
|
US $0.10-0.10 / kg | 0.005kg | 99.99% | 20 tons | Zibo Hangyu Biotechnology Development Co., Ltd | ||
2023-11-01 | (R)-5,7-difluorochroman-4-ol
1270294-05-7
|
US $0.00-0.00 / kg | 0.1kg | 99.0%min | 2000kg | Hangzhou ICH Biofarm Co., Ltd |
- (R)-5,7-difluorochroman-4-ol
1270294-05-7
- US $0.00 / kg
- 98%
- Shanghai Joiny Pharmaceutical Co.,LTD
- (R)-5,7-difluorochroman-4-ol
1270294-05-7
- US $0.10-0.10 / kg
- 99.99%
- Zibo Hangyu Biotechnology Development Co., Ltd
- (R)-5,7-difluorochroman-4-ol
1270294-05-7
- US $0.00-0.00 / kg
- 99.0%min
- Hangzhou ICH Biofarm Co., Ltd
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