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ChemicalBook >> CAS DataBase List >>N-(3-chloro-4-fluorophenyl)-2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-amine

N-(3-chloro-4-fluorophenyl)-2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-amine

N-(3-chloro-4-fluorophenyl)-2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-amine Structure
N-(3-chloro-4-fluorophenyl)-2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-amine structure
CAS No.
1019106-73-0
Chemical Name:
N-(3-chloro-4-fluorophenyl)-2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-amine
Synonyms
KCa2 channel modulator 1;N-(3-chloro-4-fluorophenyl)-2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-amine;4-Pyrimidinamine, N-(3-chloro-4-fluorophenyl)-2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-methyl-
CBNumber:
CB23523551
Molecular Formula:
C16H15ClFN5
Molecular Weight:
331.78
MDL Number:
MOL File:
1019106-73-0.mol
Last updated:2025-04-18 09:51:55
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N-(3-chloro-4-fluorophenyl)-2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-amine Properties

Boiling point 527.7±60.0 °C(Predicted)
Density 1.36±0.1 g/cm3(Predicted)
pka 3.70±0.10(Predicted)

N-(3-chloro-4-fluorophenyl)-2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-amine Chemical Properties,Uses,Production

Uses

KCa2 channel modulator 1 (compound 2o) is a potent subtype-selective positive modulator of KCa2 channel. KCa2 channel modulator 1 potentiates human KCa2.3 channels with an EC50 value of 0.19 μM and 0.99 μM on the rat KCa2.2 channel subtype[1].

References

[1] El-Sayed NS, et al. Structure-Activity Relationship Study of Subtype-Selective Positive Modulators of KCa2 Channels. J Med Chem. 2022;65(1):303-322. DOI:10.1021/acs.jmedchem.1c01473

N-(3-chloro-4-fluorophenyl)-2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-amine Preparation Products And Raw materials

Raw materials

Preparation Products

N-(3-chloro-4-fluorophenyl)-2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-amine Suppliers

Global( 2)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+8613564774135 zijue.cai@tsbiochem.com United States 19881 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 19727 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
TargetMol Chemicals Inc. 58

View Lastest Price from N-(3-chloro-4-fluorophenyl)-2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-amine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
KCa2 channel modulator 1 pictures 2024-10-24 KCa2 channel modulator 1
1019106-73-0
 US $1980.00-2500.00 / mg 10g TargetMol Chemicals Inc.
N-(3-chloro-4-fluorophenyl)-2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-amine KCa2 channel modulator 1 4-Pyrimidinamine, N-(3-chloro-4-fluorophenyl)-2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-methyl- 1019106-73-0