Flunarizine dihydrochloride
- CAS No.
- 30484-77-6
- Chemical Name:
- Flunarizine dihydrochloride
- Synonyms
- FLUNARIZINE HCL;FLUNARIZINE HYDROCHLORIDE;Gradient;Flunarizine dihydrochloride CRS;Mondus;Issium;r14950;Flunarl;kw-3149;Flunagen
- CBNumber:
- CB2377940
- Molecular Formula:
- C26H28Cl2F2N2
- Molecular Weight:
- 477.42
- MDL Number:
- MFCD00058198
- MOL File:
- 30484-77-6.mol
- MSDS File:
- SDS
| Melting point | 188-190?C |
|---|---|
| storage temp. | 2-8°C |
| solubility | chloroform/methanol (9:1): 50 mg/mL, clear, colorless |
| form | Solid |
| color | White to Off-White |
| Merck | 13,4170 |
| BRN | 4284243 |
| CAS DataBase Reference | 30484-77-6(CAS DataBase Reference) |
| FDA UNII | C11102TO53 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312+P330-P501 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | TK9187000 | |||||||||
| NFPA 704 |
|
Flunarizine dihydrochloride price More Price(33)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | F8257 | Flunarizine dihydrochloride ≥98% (TLC) | 30484-77-6 | 1g | $79.5 | 2024-03-01 | Buy |
| Sigma-Aldrich | F8257 | Flunarizine dihydrochloride ≥98% (TLC) | 30484-77-6 | 10g | $469 | 2024-03-01 | Buy |
| Alfa Aesar | J62969 | Flunarizine dihydrochloride, 99% | 30484-77-6 | 1g | $62.65 | 2024-03-01 | Buy |
| Cayman Chemical | 20385 | Flunarizine (hydrochloride) ≥98% | 30484-77-6 | 1g | $36 | 2024-03-01 | Buy |
| Cayman Chemical | 20385 | Flunarizine (hydrochloride) ≥98% | 30484-77-6 | 5g | $163 | 2024-03-01 | Buy |
Flunarizine dihydrochloride Chemical Properties,Uses,Production
Chemical Properties
White Solid
Originator
Sibelium,Janssen,W. Germany,1977
Uses
antipsychotic, H1 antihistamine
Uses
Flunarizine dihydrochloride has been used to study the effect of flunarizine on epileptiform activity. It is also used to study its effect on high-potassium induced increase of intracellular free calcium.
Uses
Calcium channel blocker; fluorinated derivative of Cinnarizine. Vasodilator (cerebral and peripheral). This is the labeled analog.
Definition
ChEBI: Flunarizine hydrochloride is a diarylmethane.
Manufacturing Process
A mixture of 14.3 parts of di-(p-fluorophenyl)-chloromethane, 10.1 parts of 1-
cinnamylpiperazine, 12.7 parts of sodium carbonate, a few crystals of
potassium iodide in 200 parts of 4-methyl-2-pentanone is stirred and refluxed
for 21 hours. The reaction mixture is cooled and 50 parts of water are added.
The organic layer is separated, dried, filtered and evaporated.
The oily residue is dissolved in 480 parts of anhydrous diisopropyl ether. This
solution is boiled with activated charcoal, filtered and to the clear filtrate is
added an excess of 2-propanol, previously saturated with gaseous hydrogen
chloride. The precipitated salt is filtered off and recrystallized from a mixture
of 2-propanol and ethanol, yielding 1-cinnamyl-4-(di-p-fluorobenzhydryl)
piperazine dihydrochloride, MP 251.5°C.
Therapeutic Function
Vasodilator
General Description
Flunarizine has antihistamine, anticonvulsant and vestibular depressive properties. It protects endothelial cells from calcium overload-induced damage. Flunarizine is used to treat epilepsy, migraine prophylaxis, cerebral blood flow disturbances, peripheral vascular disease and vertigo.
Biological Activity
Dual Na + /Ca 2+ channel blocker; a cerebral and peripheral vasodilator. Neuroprotective.
Biochem/physiol Actions
Blocks T-type Ca2+/Na+ channels; inhibits K+-induced catecholamine release from chromaffin cells
Flunarizine dihydrochloride Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1803 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21634 | 55 |
| Hubei XinRunde Chemical Co., Ltd. | +8615102730682 | bruce@xrdchem.cn | CHINA | 566 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32957 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29882 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| HubeiwidelychemicaltechnologyCo.,Ltd | 18627774460 | faith@widelychemical.com | CHINA | 742 | 58 |
| Shanghai Longyu Biotechnology Co., Ltd. | +8619521488211 | info@longyupharma.com | China | 2538 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39894 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49374 | 58 |
View Lastest Price from Flunarizine dihydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-19 | Flunarizine dihydrochloride
30484-77-6
|
US $39.00 / mg | 100% | 10g | TargetMol Chemicals Inc. | ||
 |
2024-11-19 | Flunarizine dihydrochloride
30484-77-6
|
US $39.00 / mg | 100% | 10g | TargetMol Chemicals Inc. | ||
 |
2024-04-23 | Flunarizine Hydrochloride
30484-77-6
|
US $50.00 / kg | 1kg | 99.9% | 200000kg | Ouhuang Engineering Materials (Hubei) Co., Ltd |
-
- Flunarizine dihydrochloride
30484-77-6
- US $39.00 / mg
- 100%
- TargetMol Chemicals Inc.
-
- Flunarizine dihydrochloride
30484-77-6
- US $39.00 / mg
- 100%
- TargetMol Chemicals Inc.
-
- Flunarizine Hydrochloride
30484-77-6
- US $50.00 / kg
- 99.9%
- Ouhuang Engineering Materials (Hubei) Co., Ltd