ChemicalBook >> CAS DataBase List >>3-Methyl-7-phenyl-6-oxa-3-azabicyclo[6.4.0]dodeca-8,10,12-triene

3-Methyl-7-phenyl-6-oxa-3-azabicyclo[6.4.0]dodeca-8,10,12-triene

3-Methyl-7-phenyl-6-oxa-3-azabicyclo[6.4.0]dodeca-8,10,12-triene structure

CAS No.: 13669-70-0

Chemical Name:: 3-Methyl-7-phenyl-6-oxa-3-azabicyclo[6.4.0]dodeca-8,10,12-triene

Synonyms: NEFOPAM;Nefopan;Nefopami;fenazoxine;HCL Nefopam;(?)-Nefopam;NEFOPAMI HCL;Induced insect;Nefopam HCL CP2000;Nefopanhydrochloride

CBNumber:: CB2379272

Molecular Formula:: C17H19NO

Molecular Weight:: 253.34

MDL Number:: MFCD00056181

MOL File:: 13669-70-0.mol

MSDS File:: SDS

Last updated:2024-03-19 15:37:50

Request For Quotation

3-Methyl-7-phenyl-6-oxa-3-azabicyclo[6.4.0]dodeca-8,10,12-triene Properties

Boiling point	396.54°C (rough estimate)
Density	1.0078 (rough estimate)
refractive index	1.5400 (estimate)
storage temp.	2-8°C
pka	9.16±0.70(Predicted)
CAS DataBase Reference	13669-70-0(CAS DataBase Reference)
FDA UNII	4UP8060B7J
ATC code	N02BG06

3-Methyl-7-phenyl-6-oxa-3-azabicyclo[6.4.0]dodeca-8,10,12-triene price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Biorbyt Ltd	orb134818	Nefopanhydrochloride >99%	13669-70-0	100mg	$510	2021-12-16	Buy
American Custom Chemicals Corporation	API0003526	NEFOPAM 95.00%	13669-70-0	1G	$675.15	2021-12-16	Buy
Biorbyt Ltd	orb134818	Nefopanhydrochloride >99%	13669-70-0	250mg	$912.9	2021-12-16	Buy
Biorbyt Ltd	orb134818	Nefopanhydrochloride >99%	13669-70-0	1g	$1504.5	2021-12-16	Buy
American Custom Chemicals Corporation	API0003526	NEFOPAM 95.00%	13669-70-0	5G	$1697.85	2021-12-16	Buy

Product number	Packaging	Price	Buy
orb134818	100mg	$510	Buy
API0003526	1G	$675.15	Buy
orb134818	250mg	$912.9	Buy
orb134818	1g	$1504.5	Buy
API0003526	5G	$1697.85	Buy

3-Methyl-7-phenyl-6-oxa-3-azabicyclo[6.4.0]dodeca-8,10,12-triene Chemical Properties,Uses,Production

Originator

Ajan,Kettelhack Riker,W. Germany,1976

Uses

Nefopam is a non-opioid non-steroidal centrally acting analgesic.

Definition

ChEBI: 5-methyl-1-phenyl-3,4,5,6-tetrahydro-1H-2,5-benzoxazocine is a member of the class of benzoxazocines that is 3,4,5,6-tetrahydro-1H-2,5-benzoxazocine substituted by phenyl and methyl groups at positions 1 and 5 respectively. It is a benzoxazocine and a tertiary amino compound.

Manufacturing Process

The starting material is prepared by reacting 2-benzoylbenzoic acid with thionyl chloride and then with 2-methylaminoethanol. 20.0 grams (0.07 mol) of N-(2-hydroxyethyl)-N-methyl-o-benzoylbenzamide is suspended in 100 ml tetrahydrofuran and then slowly added in small portions to a solution of 5.5 grams (0.14 mol) of lithium aluminum hydride in 150 ml tetrahydrofuran with cooling and stirring. The mixture is then refluxed for 18 hours, cooled and then to it is successively added 5.5 ml water, 5.5 ml of 3.75 N sodium hydroxide and 16 ml water. After removal of precipitated salts by filtration, the solution remaining is concentrated under reduced pressure and the residue dried to yield 19.5 grams of crude product. Yield after conversion to the hydrochloride salt and recrystallization is 17.0 grams (89%), MP 128° to 133°C.
5-methyl-1-phenyl-1,3,4,6-tetrahydro-5H-benz[f] -2,5-oxazocine is prepared as follows. 3.0 grams (0.011 mol) of 2-([N-(2-hydroxyethyl)-Nmethyl]amino)methylbenzhydrol, prepared as described above, 3.0 grams ptoluenesulfonic acid and 15 ml benzene are heated together with stirring until all the benzene is distilled off. The residual oil is heated to 105°C and held at this temperature for 1 hour, then cooled and dissolved in 30 ml water. This aqueous solution is then basified to pH 10.0 with 12 N sodium hydroxide, extracted with ether, and the extracts washed with water, dried over anhydrous sodium sulfate and the solvent removed under reduced pressure. The 2.26 grams (81%) oil remaining is converted to the hydrochloride salt, MP 238° to 242°C.

brand name

Acupan (3M Pharmaceuticals).

Therapeutic Function

Muscle relaxant, Antidepressant

Clinical Use

Nefopam is a centrally acting analgesic without opioid properties. It induces inhibition of NA and 5-HT reuptake and has antimuscarinic and sympatomimetic actions which all might be relevant for its analgesic action. Nefopam is used orally and parenterally for the treatment of moderately severe pain. Side effects are nausea, vomiting, sweating, nervousness, tachycardia, and occasionally convulsions. Nefopam should not be used in combination with MAO inhibitors.

3-Methyl-7-phenyl-6-oxa-3-azabicyclo[6.4.0]dodeca-8,10,12-triene Preparation Products And Raw materials

Raw materials

p-Toluenesulfonic acid Benzophenone Hydrogen bromide PARA TOLUENE Potassium borohydride

Benzhydrol Benzoic acid Thionyl chloride Activated carbon Hydrochloric acid

2-Benzoylbenzoic acid 2-Methylaminoethanol Lithium Aluminum Hydride

1of3

Preparation Products

3-Methyl-7-phenyl-6-oxa-3-azabicyclo[6.4.0]dodeca-8,10,12-triene Suppliers

Global( 89)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Xiamen Wonderful Bio Technology Co., Ltd.	+8613043004613	Sara@xmwonderfulbio.com	China	283	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21637	55
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28172	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49374	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29814	58
Hebei Mojin Biotechnology Co., Ltd	+86 13288715578 +8613288715578	sales@hbmojin.com	China	12835	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	sales@tnjchem.com	China	34553	58
ANHUI WITOP BIOTECH CO., LTD	+8615255079626	eric@witopchemical.com	China	23541	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	23025	58

Supplier	Advantage
Xiamen Wonderful Bio Technology Co., Ltd.	58
Henan Tianfu Chemical Co.,Ltd.	55
Hubei Jusheng Technology Co.,Ltd.	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
Hebei Mojin Biotechnology Co., Ltd	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
ANHUI WITOP BIOTECH CO., LTD	58
Dideu Industries Group Limited	58

View Lastest Price from 3-Methyl-7-phenyl-6-oxa-3-azabicyclo[6.4.0]dodeca-8,10,12-triene manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-01-18	Nefopam 13669-70-0	US $120.00 / kg	1kg	99%	8000	Xiamen Wonderful Bio Technology Co., Ltd.
2023-01-31	3-Methyl-7-phenyl-6-oxa-3-azabicyclo[6.4.0]dodeca-8,10,12-triene 13669-70-0	US $50.00 / KG	1KG	99%	5000KG	Hebei Mojin Biotechnology Co., Ltd
2021-10-29	Nefopam 13669-70-0	US $0.00 / ASSAYS	100ASSAYS	99.99%	10000	Jiangsu Monade Biological Technology Co., Ltd.

Nefopam
13669-70-0
US $120.00 / kg
99%
Xiamen Wonderful Bio Technology Co., Ltd.

3-Methyl-7-phenyl-6-oxa-3-azabicyclo[6.4.0]dodeca-8,10,12-triene
13669-70-0
US $50.00 / KG
99%
Hebei Mojin Biotechnology Co., Ltd

Nefopam
13669-70-0
US $0.00 / ASSAYS
99.99%
Jiangsu Monade Biological Technology Co., Ltd.

13669-70-0(3-Methyl-7-phenyl-6-oxa-3-azabicyclo[6.4.0]dodeca-8,10,12-triene)Related Search:

3-Methyl-7-phenyl-6-oxa-3-azabicyclo[6.4.0]dodeca-8,10,12-triene 3-methyl-7-phenyl-6-oxa-3-azabicyclo[6.4.0]dodeca-8,10,12-triene hydrochloride tofenacin 2-(BENZYLOXY)-ETHYLAMINE Diphenhydramine

N-Benzyl-N-methylethanolamine Diphenhydramine Hydrochloride 2-(BENZYLOXY)-1-ETHANAMINE HYDROCHLORIDE 2-Methylbenzhydrol N,N-dimethylbenzylamine hydrochloride

2-(DIPHENYLMETHOXY)-N-METHYLETHYLAMINE [2-(aminomethyl)phenyl]methanol tofenacin hydrochloride 2-methyl-benzenemethanaminhydrochloride CHEMBRDG-BB 9071568

1-PHENYL-3,4,5,6-TETRAHYDRO-1H-2,5-BENZOXAZOCINE-5-CARBONITRILE

1of4

NEFOPAM 3-methyl-7-phenyl-6-oxa-3-azabicyclo[6.4.0]dodeca-8,10,12-triene 3,4,5,6-tetrahydro-5-methyl-1-phenyl-1h-2,5-benzoxazocine 3,4,5,6-tetrahydro-5-methyl-1-phenyl-1h-5-benzoxazocine fenazoxine NEFOPAMI HCL Nefopam HCL CP2000 Nefopanhydrochloride Nefopam (base and/or unspecified salts) 1H-2,5-Benzoxazocine,3,4,5,6-tetrahydro-5-Methyl-1-phenyl- 5-Methyl-1-phenyl-3,4,5,6-tetrahydro-1H-benzo[f][1,4]oxazocine Induced insect Nefopami hydrochloride Nefopami Nefopan HCL Nefopam (?)-Nefopam 3-Methyl-7-phenyl-6-oxa-3-azabicyclo[6.4.0]dodeca-8,10,12-triene USP/EP/BP 13669-70-0 156-2-24 C17H19NO ACTIVE PHARMACEUTICAL INGREDIENTS