(TRIMETHYLSILYL)ACETONITRILE
- CAS No.
- 18293-53-3
- Chemical Name:
- (TRIMETHYLSILYL)ACETONITRILE
- Synonyms
- TMSAN;2-(Trimethy;Einecs 242-169-5;TRIMETHYLSILYACETONITRILE;(TRIMETHYLSILYL)ACETONITRILE;(CYANOMETHYL)TRIMETHYLSILANE;2-Trimethylsilylacetonitrile;trimethylsilanyl-acetonitrile;2-(Trimethylsilyl)acetonitrile;Acetonitrile, (trimethylsilyl)-
- CBNumber:
- CB2403137
- Molecular Formula:
- C5H11NSi
- Molecular Weight:
- 113.23
- MDL Number:
- MFCD00001882
- MOL File:
- 18293-53-3.mol
| Boiling point | 65-70 °C20 mm Hg(lit.) |
|---|---|
| Density | 0.827 g/mL at 25 °C(lit.) |
| refractive index |
n |
| Flash point | 122 °F |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Sol most common organic solvents. |
| form | Liquid |
| color | Clear colorless to straw |
| Specific Gravity | 0.829 |
| Hydrolytic Sensitivity | 4: no reaction with water under neutral conditions |
| BRN | 1738845 |
| InChIKey | WJKMUGYQMMXILX-UHFFFAOYSA-N |
| FDA UNII | 5XB7XHD8BU |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H226-H301+H311+H331-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P310-P305+P351+P338-P311 |
| Hazard Codes | T |
| Risk Statements | 10-23/24/25-36/37/38 |
| Safety Statements | 26-36/37/39-45 |
| RIDADR | UN 1993 3/PG 3 |
| WGK Germany | 3 |
| F | 21 |
| TSCA | No |
| HazardClass | 3.2 |
| PackingGroup | III |
| HS Code | 29310099 |
(TRIMETHYLSILYL)ACETONITRILE price More Price(1)
(TRIMETHYLSILYL)ACETONITRILE Chemical Properties,Uses,Production
Physical properties
bp 84–85 °C/54 mmHg, 66 °C/35 mmHg, 65–70 °C/20 mmHg;3 d 0.827 g cm?3.
Uses
(Trimethylsilyl)acetonitrile has been used in catalytic cyanomethylation of various carbonyl compounds in the presence of Lewis bases.
Uses
α-carbanion is a useful alternative to LiCH2CN for nucleophilic cyanomethylation; (Z)-selective Peterson alkenation). Trimethylsilylacetonitrile participates in the following synthesis reactions: Metalation, Peterson Alkenation (Cyanomethylenation), Michael Addition, Reactions with Other Electrophiles, Cyanomethylation, Metal-Catalyzed Reactions etc.
Preparation
From chlorotrimethylsilane, zinc, and XCH2CN, (X = Cl, 61% yield; X = Br, 81% yield).
Purification Methods
Check if NMR and IR spectra show impurities; if present dissolve it in *C6H6 (10volumes), wash it with buffer (AcOH/AcONa pH ca 7) several times, dry (CaCl2) it, evaporate and distil it. IR: (CCl4) 2215 (CN) cm-1, NMR (CCl4): 0.23 (s, 9H, SiMe3), and 1.53 (s, 2H, CH2CN). [Matsuda et al. J Chem Soc, Perkin Trans 1 26 1979, Beilstein 4 IV 3974.]
(TRIMETHYLSILYL)ACETONITRILE Preparation Products And Raw materials
Raw materials
Preparation Products
1of2
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10310 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 17453 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49374 | 58 |
| Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | sale04@alfachem.cn | China | 13415 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30240 | 58 |
| Shanxi Xuanran Import and Export Trade Co., Ltd. | +8617735180244 | mike_yan@xuanranglobal.com | CHINA | 4017 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | China | 52849 | 58 |
| Hebei Weibang Biotechnology Co., Ltd | +8617732866630 | bess@weibangbio.com | China | 18153 | 58 |
| PT CHEM GROUP LIMITED | peter68@ptchemgroup.com | China | 35425 | 58 | |
| ZHEJIANG JIUZHOU CHEM CO., LTD | +86-0576225566889 +86-13454675544 | admin@jiuzhou-chem.com；jamie@jiuzhou-chem.com；alice@jiuzhou-chem.com | China | 12272 | 58 |
View Lastest Price from (TRIMETHYLSILYL)ACETONITRILE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-11-18 | (TRIMETHYLSILYL)ACETONITRILE
18293-53-3
|
US $0.00-0.00 / kg | 1kg | 99% | 500000kg | Hebei Kingfiner Technology Development Co.Ltd | |
 |
2021-07-02 | (Trimethylsilyl)acetonitrile 99%
18293-53-3
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
-
- (TRIMETHYLSILYL)ACETONITRILE
18293-53-3
- US $0.00-0.00 / kg
- 99%
- Hebei Kingfiner Technology Development Co.Ltd
-
- (Trimethylsilyl)acetonitrile 99%
18293-53-3
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd