(-)-MK-801 MALEATE
- CAS No.
- 77086-22-7
- Chemical Name:
- (-)-MK-801 MALEATE
- Synonyms
- mk801;(+)MK108;(+)MK801;MK 801 ;MK801;(-)-MK-801 MALEATE;Dizocipine maleate;(+)Mk801/MK801/MK-801;(+)-MK-801·Maleic acid;MK-801(Dizocilpine)Maleate;(+/-)-mk-801 hydrogen maleate
- CBNumber:
- CB2407483
- Molecular Formula:
- C20H19NO4
- Molecular Weight:
- 337.38
- MDL Number:
- MFCD00082465
- MOL File:
- 77086-22-7.mol
- MSDS File:
- SDS
Melting point | 208.5-210° |
---|---|
alpha | D20 +114° (c = 0.0128 g/2 ml ethanol) |
storage temp. | Inert atmosphere,2-8°C |
solubility | DMSO: >20 mg/mL |
form | solid |
color | white |
optical activity | [α]25/D +117°, c = 1 in methanol(lit.) |
InChIKey | QLTXKCWMEZIHBJ-FWHYOZOBSA-N |
FDA UNII | 6LR8C1B66Q |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() ![]() ![]() GHS07,GHS08,GHS06 |
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Signal word | Danger | |||||||||
Hazard statements | H372-H370-H361-H301-H319 | |||||||||
Precautionary statements | P260-P264-P270-P314-P501-P260-P264-P270-P307+P311-P321-P405-P501-P201-P202-P281-P308+P313-P405-P501-P264-P280-P305+P351+P338-P337+P313P-P264-P270-P301+P310-P321-P330-P405-P501 | |||||||||
Safety Statements | 22-24/25 | |||||||||
WGK Germany | 3 | |||||||||
RTECS | HP1093575 | |||||||||
NFPA 704 |
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(-)-MK-801 MALEATE price More Price(23)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | M107 | (+)-MK-801 hydrogen maleate powder | 77086-22-7 | 5mg | $119 | 2024-03-01 | Buy |
Sigma-Aldrich | 475878 | (+)-MK 801 Maleate | 77086-22-7 | 10mg | $152 | 2022-05-15 | Buy |
Alfa Aesar | J63917 | Dizocilpine maleate, 99+% | 77086-22-7 | 10mg | $120 | 2024-03-01 | Buy |
Alfa Aesar | J63917 | Dizocilpine maleate, 99+% | 77086-22-7 | 50mg | $369 | 2024-03-01 | Buy |
Cayman Chemical | 10009019 | (+)-MK-801 (hydrogen maleate) ≥99% | 77086-22-7 | 10mg | $72 | 2024-03-01 | Buy |
(-)-MK-801 MALEATE Chemical Properties,Uses,Production
Uses
Dizocilpine maleate is used to interact at the NMDA-associated ion channel, preventing Ca2+ flux and blocking NMDA-induced depolarizations. (+)-MK 801 demonstrates potent neuroprotective effects against excitotoxic insult, showing substantial protection against neuron loss produced by NMDA and quinolinic acid introduction.
Uses
(-)-MK-801 MALEATE acts as an NMDA receptor antagonist. It is selective and potent, but noncompetitive, used in various ischemia treatments.
Uses
(-)-MK-801 MALEATE is probe for NMDA receptors
Definition
ChEBI: Dizocilpine maleate is a maleate salt obtained by reaction of dizocilpine with one equivalent of maleic acid. It has a role as an anaesthetic, an anticonvulsant, a neuroprotective agent, a nicotinic antagonist and a NMDA receptor antagonist. It is a maleate salt and a tetracyclic antidepressant. It contains a dizocilpine(1+).
General Description
A highly potent, selective and non-competitive NMDA receptor antagonist that acts by binding to a site located within the NMDA associated ion channel, preventing Ca2+ flux. An effective anti-ischemic agent in several animal models. Has been used to develop an in vivo model of NMDA receptor-dependent apoptotic neurodegenerative disease in developing rat brains. Has also been used to develop an in vitro model of NMDA receptor-specific Ca2+ entry induced seizures.
Biological Activity
(-)-MK-801 MALEATE is a potent, selective and non-competitive NMDA receptor antagonist. Acts by binding to a site located within the NMDA associated ion channel and thus prevents Ca 2+ flux. An effective anti-ischemic agent in several animal models. Also available as part of the Mixed NMDA Receptor Tocriset™ .
Biochem/physiol Actions
Primary TargetNMDA receptor
storage
Room temperature
References
[1] wong eh, kemp ja, priestley t, knight ar, woodruff gn, iversen ll . the anticonvulsant mk-801 is a potent n-methyl-d-aspartate antagonist. proc natl acad sci u s a. 1986 sep;83(18):7104-8.
(-)-MK-801 MALEATE Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9337 | 55 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32836 | 60 |
career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29825 | 58 |
Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30250 | 58 |
Xi'an MC Biotech, Co., Ltd. | 029-89275612 +8618991951683 | mcbio_sales@163.com | China | 2255 | 58 |
Finetech Industry Limited | +86-27-87465837 +8618971612321 | info@finetechnology-ind.com | China | 9641 | 58 |
Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10522 | 58 |
Henan Alfa Chemical Co., Ltd | +8618339805032 | alfa4@alfachem.cn | China | 13185 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
GLR Innovations | +91 9891111994 | info@glrgroup.in | India | 4542 | 58 |
View Lastest Price from (-)-MK-801 MALEATE manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
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2020-02-06 | (-)-MK-801 MALEATE
77086-22-7
|
US $1.00 / KG | 1KG | 99%HPLC | 100KG | Career Henan Chemical Co |
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- (-)-MK-801 MALEATE
77086-22-7
- US $1.00 / KG
- 99%HPLC
- Career Henan Chemical Co