Sesamol
- CAS No.
- 533-31-3
- Chemical Name:
- Sesamol
- Synonyms
- benzo[d][1,3]dioxol-5-ol;SesaMe phenol;1,3-BENZODIOXOL-5-OL;5-BENZODIOXOLOL;3,4-METHYLENEDIOXYPHENOL;SESAMOL;Sesamolr;NSC 59256;S**Sesamol;Sesamol>
- CBNumber:
- CB2413594
- Molecular Formula:
- C7H6O3
- Molecular Weight:
- 138.12
- MDL Number:
- MFCD00005827
- MOL File:
- 533-31-3.mol
- MSDS File:
- SDS
Melting point | 62-65 °C (lit.) |
---|---|
Boiling point | 113-116°C 2mm |
Density | 1.2112 (rough estimate) |
refractive index | 1.4850 (estimate) |
Flash point | 113-116°C/2mm |
storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
solubility | Chloroform, Methanol |
form | crystalline |
pka | 10.08±0.20(Predicted) |
color | off-white to tan |
Water Solubility | slightly soluble |
Sensitive | Light Sensitive |
BRN | 127405 |
InChIKey | LUSZGTFNYDARNI-UHFFFAOYSA-N |
LogP | 1.253 (est) |
CAS DataBase Reference | 533-31-3(CAS DataBase Reference) |
EWG's Food Scores | 1-4 |
FDA UNII | 94IEA0NV89 |
NIST Chemistry Reference | 1,3-Benzodioxol-5-ol(533-31-3) |
EPA Substance Registry System | Sesamol (533-31-3) |
Sesamol price More Price(52)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | S3003 | Sesamol 98% | 533-31-3 | 5G | $38.5 | 2024-03-01 | Buy |
Sigma-Aldrich | S3003 | Sesamol 98% | 533-31-3 | 25g | $88.4 | 2024-03-01 | Buy |
Sigma-Aldrich | PHL80111 | Sesamol phyproof? Reference Substance | 533-31-3 | 50MG | $262 | 2024-03-01 | Buy |
Sigma-Aldrich | 41557 | Sesamol analytical standard | 533-31-3 | 100mg | $74.7 | 2022-05-15 | Buy |
TCI Chemical | S0418 | Sesamol >98.0%(GC) | 533-31-3 | 25g | $66 | 2024-03-01 | Buy |
Sesamol Chemical Properties,Uses,Production
Description
Sesamol is found in sesame seeds and sesame oil. It is a well-known antioxidant. It has antioxidant, chemoprevention, antimutagenic, and antihepatotoxic activities and can induce the apoptosis of cancer and cardiovascular cells. It can be used in the synthesis of paroxetine.
Reference
[1] M. A. Ansari, Z. Fatima, S. Hameed, Sesamol: A Natural Phenolic Compound with Promising Anticandidal Potential, Journal of Pathogens, vol. 2014, Article ID 895193.
[2] T. Geetha, B. Rohit, K. Pal, Sesamol: an efficient antioxidant with potential therapeutic benefits, Medicinal Chemistry, 2009, vol. 5, pp. 367-371.
[3] Amin F. Majdalawieh, Zeenah R. Mansour. “Sesamol, a major lignan in sesame seeds (Sesamum indicum): Anti-cancer properties and mechanisms of action.” European journal of pharmacology 855 (2019): Pages 75-89.
[4] Geetha, T. et al. “Biopharmaceutical profiling of sesamol: physiochemical characterization, gastrointestinal permeability and pharmacokinetic evaluation.” RSC Advances 6 (2014): 4083–4091.
Chemical Properties
off-white to beige crystalline powder
Uses
Sesamol (Paroxetine Anhydrous EP Impurity B) is a natural component of sesame oil with antioxidant activity. Sesamol has potential protective effects against free radicals as well as some antifungal activity. Sesamol can also be used as an intermediate in the preparation of antidepressants such as Paroxetine (P205750).
Definition
ChEBI: Sesamol is a member of benzodioxoles.
benefits
Sesamol, 5-hydroxy-1,3-benzodioxole or 3,4-methylene-dioxyphenol, is a water-soluble phenolic lignan isolated from roasted sesame seeds and processed sesame oil. Various studies investigated the anti-cancer therapeutic potential of sesamol, and the literature provided reveals compelling evidence that sesamol acts as a metabolic regulator and possesses antioxidant, anti-mutagenic, anti-hepatotoxic, anti-inflammatory, anti-aging, and chemopreventive properties.
Synthesis Reference(s)
Tetrahedron Letters, 19, p. 3085, 1978 DOI: 10.1016/S0040-4039(01)94947-0
General Description
Sesamol, a principal phytophenol of sesame oil lignans, is typically used as a dietary compound.(10)
Biological Activity
Sesamol has a wide range of biological actions including inhibition of lipid peroxidation and enhancement of radical scavenging, upregulation of antioxidant enzymes, suppression of TNFα 80 and IL-1β expression, inhibition of NF-κB 81 signaling, suppression of LOX-1 82 and 5-LOX activity, induction of 83 apoptosis, arresting cell growth at different phases of the cell cycle; and modulation of caspase-3, p53, Bax, and Bcl2 expression[3].
Pharmacokinetics
Sesamol (100 mg/kg body weight in rats) is reportedly eliminated from the body within 0-4 hours of oral administration as conjugates. The maximum plasma concentration (Cmax), half-life (t1/2), and area under the curve (AUC) of sesamol were found to be 1.4±0.7 μg/mL, 563.7±36.9 min, and 501.3±200.8 min μg/mL, respectively, following oral administration of 50 mg/kg body weight dose of sesamol to rats. A rapid decline in plasma concentrations and an oral bioavailability (BA) of 35.5 ± 8.5% has been reported for sesamol in Sprague Dawley rats. Sesamol is reported to undergo reductive cleavage to 2-methoxybenzene-1,4-diol and benzene-1,2,4-triol. Small quantities of these metabolites are observed in the urine of rats fed with sesamol. Moreover, sesamol or its metabolite was not detected when sesamol was incubated in vitro with rat faecal microbiota. Sesamol is excreted unchanged in the excreta, while it is a glucuronide in the urine. It is indicated that sesamol and its conjugated metabolites are rapidly eliminated from urine and feces in 0–4 h[4].
Solubility in water
Sesamol shows solubility of ~10 mg/mL (9.50-11.08 mg/ml) at all the pH<9. Further, there is a sharp increase in solubility at more alkaline pH>10, with the value being 41.83 mg/mL at pH 13[4].
Sesamol Preparation Products And Raw materials
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
.GZ HONESTCHEM CO.,LTD | +86-15013270415 | honestchemical@foxmail.com | China | 246 | 58 |
Hangzhou Zelixir Biotech Co., Ltd. | +8618867646786 | neal.chen@zelixir.com | China | 232 | 58 |
Hebei Longbang Technology Co., LTD | +86-18032476855 +86-18032476855 | admin@hblongbang.com | China | 935 | 58 |
Shanghai Likang New Materials Co., Limited | +86-16631818819 +86-17736933208 | 3684455296@qq.com | China | 9311 | 58 |
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD | +8615383190639 | admin@86-ss.com | China | 1000 | 58 |
ZHEJIANG JIUZHOU CHEM CO., LTD | +86-0576225566889 +86-13454675544 | admin@jiuzhou-chem.com;jamie@jiuzhou-chem.com;alice@jiuzhou-chem.com | China | 12272 | 58 |
Hebei Guanlang Biotechnology Co,.LTD | +8619930503252 | daisy@crovellbio.com | China | 5828 | 58 |
Anhui Yiao New Material Technology Co., Ltd | +86-18033737140 +86-17354101231 | sales1@hbganmiao.com | China | 253 | 58 |
Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | Mandy@hangyubiotech.com | China | 10977 | 58 |
Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 | qinhe02@xaltbio.com | China | 1000 | 58 |
View Lastest Price from Sesamol manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
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2024-08-24 | Sesamol
533-31-3
|
US $999.00-666.00 / kg | 1kg | 99% | 5000 | HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD | |
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2024-08-23 | Sesamol
533-31-3
|
US $6.00 / kg | 1kg | 99% | 2000KG/Month | HebeiShuoshengImportandExportco.,Ltd | |
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2024-08-20 | Sesamol
533-31-3
|
US $5.00-2.00 / KG | 1KG | 99% | 10000kg | Hebei Guanlang Biotechnology Co,.LTD |