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SPDP

CAS No.
68181-17-9
Chemical Name:
SPDP
Synonyms
SPDP;SPDP NHS ester;SPDP Crosslinker;3-(2-PYRIDYLDITHIO)-PROPIONIC ACID-OSU;SUCCINIMIDYL 3-(2-PYRIDYLDITHIO)PROPIONATE;N-SUCCINIMIDYL 3-[2-PYRIDYLDITHIO]PROPIONATE;3-(Pyridin-2-yldisulfanyl)-propionic acid-OS;3-(PYRIDIN-2-YLDISULFANYL)-PROPIONIC ACID-OSU;N-succinimidyl-3-(2-pyridyldithiol)propionate;N-SUCCINIMIDYL-3-(2-PYRIDYLDITHIO)PROPIONANATE
CBNumber:
CB2446059
Molecular Formula:
C12H12N2O4S2
Molecular Weight:
312.36
MDL Number:
MFCD00009636
MOL File:
68181-17-9.mol
MSDS File:
SDS
Last updated:2024-11-19 15:53:33

SPDP Properties

Melting point 84-86 °C(lit.)
Boiling point 465.9±55.0 °C(Predicted)
Density 1.48±0.1 g/cm3(Predicted)
storage temp. -20°C
solubility acetone: 50 mg/mL
form powder
pka 1.76±0.19(Predicted)
color White to Light Yellow
BRN 1548137
Stability Hygroscopic, Moisture Sensitive
InChIKey JWDFQMWEFLOOED-UHFFFAOYSA-N
CAS DataBase Reference 68181-17-9(CAS DataBase Reference)
FDA UNII 2OHG8V08NL

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H317
Precautionary statements  P280
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  3
1-10
HS Code  29333990

SPDP price More Price(41)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich P3415 3-(2-Pyridyldithio)propionic acid N-hydroxysuccinimide ester ≥95%, powder 68181-17-9 5mg $67.1 2024-03-01 Buy
Sigma-Aldrich P3415 3-(2-Pyridyldithio)propionic acid N-hydroxysuccinimide ester ≥95%, powder 68181-17-9 25mg $205 2024-03-01 Buy
TCI Chemical S0819 N-Succinimidyl 3-(2-Pyridyldithio)propionate 68181-17-9 250MG $174 2024-03-01 Buy
TCI Chemical S0819 N-Succinimidyl 3-(2-Pyridyldithio)propionate >98.0%(HPLC) 68181-17-9 1g $390 2024-03-01 Buy
TCI Chemical S0819 N-Succinimidyl 3-(2-Pyridyldithio)propionate >98.0%(HPLC) 68181-17-9 100mg $75 2021-12-16 Buy
Product number Packaging Price Buy
P3415 5mg $67.1 Buy
P3415 25mg $205 Buy
S0819 250MG $174 Buy
S0819 1g $390 Buy
S0819 100mg $75 Buy

SPDP Chemical Properties,Uses,Production

Description

SPDP NHS ester is a heterobiofunctional crosslinker which can react with amine and sulfhydryl groups. SPDP NHS esters are membrane permeable therefore allowing them to funtion inside of cells.

Chemical Properties

White Solid

Uses

Important crosslinking reagent for the preparation of protein-protein and peptide-protein conjugates linked by disulfide bonds.

Uses

A heterobifunctional cross-linker

Uses

3-(2-Pyridyldithio)propionic acid N-hydroxysuccinimide ester (SPDP) is useful for the preparation of enzyme immunoconjugates and hapten carrier molecule conjugates.
It has been used for antibody conjugation and as a protein cross-linker.

General Description

3-(2-Pyridyldithio)propionic acid N-hydroxysuccinimide ester (SPDP) is a heterobifunctional cross-linking reagent with amine and sulfhydryl reactivity. It is typically coupled initially to molecules containing primary amines by amide bonds buffered at pH 7.5 (6.5-8.5). Second coupling specific for molecules containing free sulfhydryl by thiol-disulfide exchange buffered at pH 8.0 (7.5-8.5). Alternately, this reagent may be used as a protected thiolating reagent following initial coupling and reduction of linker. It incorporates four atom linker.

SPDP Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 234)Suppliers
Supplier Tel Email Country ProdList Advantage
career henan chemical co
+86-0371-86658258 +8613203830695 sales@coreychem.com China 29880 58
Changzhou Ansciep Chemical Co., Ltd.
+86 519 86305871 sales@ansciepchem.com CHINA 4241 58
BOC Sciences
+1-631-485-4226 inquiry@bocsci.com United States 19553 58
Chongqing Chemdad Co., Ltd
+86-023-6139-8061 +86-86-13650506873 sales@chemdad.com China 39894 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427 sales@conier.com China 49374 58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd
+8613580539051 joe@yuhengpharm.com CHINA 21142 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32161 58
Hubei Ipure Biology Co., Ltd
+8613367258412 ada@ipurechemical.com China 10319 58
HONG KONG IPURE BIOLOGY CO.,LIMITED
86 18062405514 18062405514 ada@ipurechemical.com CHINA 3461 58
Win-Win chemical CO., Limited
+86-0086-577-64498589 +86-15355981851 sales@win-winchemical.com China 14426 58

View Lastest Price from SPDP manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
SPDP pictures 2024-11-19 SPDP
68181-17-9
US $22.00 / mg 100% 10g TargetMol Chemicals Inc.
SPDP-NHS ester pictures 2024-03-27 SPDP-NHS ester
68181-17-9
US $0.00 / g 10g >99.00% 10g Xian confluore Biological Technology Co., Ltd.
SPDP pictures 2019-07-11 SPDP
68181-17-9
US $1.00 / KG 1KG 99% 25kg Career Henan Chemical Co
  • SPDP pictures
  • SPDP
    68181-17-9
  • US $22.00 / mg
  • 100%
  • TargetMol Chemicals Inc.
  • SPDP-NHS ester pictures
  • SPDP-NHS ester
    68181-17-9
  • US $0.00 / g
  • >99.00%
  • Xian confluore Biological Technology Co., Ltd.
  • SPDP pictures
  • SPDP
    68181-17-9
  • US $1.00 / KG
  • 99%
  • Career Henan Chemical Co
3-(2-PYRIDYLDITHIO)PROPIONIC ACID N-HYDROXY-SUCCINIMIDE ESTER 3-(2-PYRIDYLDITHIO)PROPIONIC ACID N-SUCCINIMIDYL ESTER 3-(2-PYRIDYLDITHIO)-PROPIONIC ACID-OSU succinimidyl3-(2-pyridyldithio)propionate(spdp) SUCCINIMIDYL 3-(2-PYRIDYLDITHIO)PROPIONATE SPDP N-SUCCINIMIDYL-3-(2-PYRIDYLDITHIO)PROPIONANATE N-SUCCINIMIDYL 3-[2-PYRIDYLDITHIO]PROPIONATE 1-[1-oxo-3-(2-pyridyldithio)propoxy]pyrrolidine-2,5-dione 2,5-Pyrrolidinedione, 1-1-oxo-3-(2-pyridinyldithio)propoxy- 3-(2-PYRIDYLDITHIO)-PROPIONIC ACID N-HYDROXYSUCCINIMIDE ESTER CRYSTALLINE 3-(Pyridin-2-yldisulfanyl)-propionic acid-OS 3-(PYRIDIN-2-YLDISULFANYL)-PROPIONIC ACID-OSU 3-(2-PYRIDYLDITHIO)PROPIONIC ACID*N-HYDR OXYSUCCINIM 3-(2-Pyridyldithio)propionic Acid N-Succinimidyl Ester SPDP 3-(Pyridin-2-yldisulfanyl)-propionic acid-OSu, SPDP 3-(2-Pyridylthio)propionic acid N-hydroxysucciniMide ester N-Succinimidyl 3-(2-Pyridyldithio)propionate SPDP Crosslinker 2,5-dioxopyrrolidin-1-yl 3-(pyridin-2-yldisulfanyl)propanoate 3-(2-Pyridyldithio)propionic acidN-hydroxyuccinimide ester≥ 97% (HPLC) N-Succinimidyl 3-(2-pyridyldithio)propionate, SPDP 1-[1-Oxo-3-(2-pyridinyldithio)propyloxy]-2,5-pyrrolidinedione 3-(2-Pyridyldithio)propionic acid 2,5-dioxo-1-pyrrolidinyl ester 3-[(2-Pyridinyl)dithio]propionic acid succinimidyl ester 3-[(2-Pyridyl)dithio]propionic acid succinimidyl ester N-[3-(2-Pyridyldithio)propionyloxy]succinimide 2,5-dioxopyrrolidin-1-yl 3-(pyridin-2-yldisulfaneyl)propanoate 3-(2-Pyridyldithio)propionic acid N-hydroxysuccinimide ester(SPDP) N-Succinimidyl3-(Pyridin-2yldithio)-propionate(SPDP) N-Succinimidyl3-(2-Pyridyldithio)propionate> Propanoic acid, 3-(2-pyridinyldithio)-, 2,5-dioxo-1-pyrrolidinyl ester 3-(2-Pyridyldithio)propionic Acid N-Hydroxysuccinimide Ester (SPDP Crosslinker) extrapure, 95% 3-(Pyridin-2-yldisulfanyl)propionic acid N-Hydroxy succinimide ester SPDP NHS ester 2,5-Dioxo-1-pyrrolidinyl 3-(2-Pyridyldisulfanyl)propanoate N-succinimidyl-3-(2-pyridyldithiol)propionate 68181-17-9 C12H12N2O4S2 BioChemical Heterobifunctional Cross-Linking Reagents Crosslinking Protein Modification Proteomics Proteomics and Protein Expression Heterobifunctional Crosslinker heteroXlink Cross Linking Reagents Nitric Oxide Reagents