ChemicalBook >> CAS DataBase List >>4-[4-(2,5-dioxo-1-phenylpyrrolidin-3-yl)piperazin-4-ium-1-yl]phenolate

4-[4-(2,5-dioxo-1-phenylpyrrolidin-3-yl)piperazin-4-ium-1-yl]phenolate

4-[4-(2,5-dioxo-1-phenylpyrrolidin-3-yl)piperazin-4-ium-1-yl]phenolate structure

CAS No.: 522649-59-8

Chemical Name:: 4-[4-(2,5-dioxo-1-phenylpyrrolidin-3-yl)piperazin-4-ium-1-yl]phenolate

Synonyms: Malic Enzyme inhibitor ME1;Malic enzyme inhibitor ME1 (Synonyms: ME1);2,5-Pyrrolidinedione, 3-[4-(4-hydroxyphenyl)-1-piperazinyl]-1-phenyl-;4-[4-(2,5-dioxo-1-phenylpyrrolidin-3-yl)piperazin-4-ium-1-yl]phenolate

CBNumber:: CB24489436

Molecular Formula:: C20H21N3O3

Molecular Weight:: 351.4

MDL Number:: MFCD03453758

MOL File:: 522649-59-8.mol

Last updated:2024-07-02 08:55:03

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4-[4-(2,5-dioxo-1-phenylpyrrolidin-3-yl)piperazin-4-ium-1-yl]phenolate Properties

Boiling point	638.1±55.0 °C(Predicted)
Density	1.342±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO: 125 mg/mL (355.72 mM)
form	Solid
pka	12.18±0.30(Predicted)
color	White to off-white

4-[4-(2,5-dioxo-1-phenylpyrrolidin-3-yl)piperazin-4-ium-1-yl]phenolate price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
DC Chemicals	DC12536	MalicEnzymeinhibitorME1 >98%	522649-59-8	1g	$2100	2021-12-16	Buy

Product number	Packaging	Price	Buy
DC12536	1g	$2100	Buy

4-[4-(2,5-dioxo-1-phenylpyrrolidin-3-yl)piperazin-4-ium-1-yl]phenolate Chemical Properties,Uses,Production

Biological Activity

Malic enzyme inhibitor ME1 (ME1; compound 1) is a potent malic enzyme (ME1) inhibitor with IC50 of 0.15 μM.

in vitro

Malic enzyme inhibitor ME1 (ME1; ME1*) (50 μM; 72 hours) shows a significant reduction in total cell numbers.
It shows a significant reduction in cell viability/metabolic activity in MTS cell.
It dose-dependently reduces the number of colonies formed by both HCT116 and HT29 cells.

Cell Viability Assay

Cell Line:	HCT116 and HT29 cell line
Concentration:	50 μM
Incubation Time:	72 hours
Result:	Showed a significant reduction in total cell numbers.

target

IC50: 0.15 μM (Malic enzyme)

4-[4-(2,5-dioxo-1-phenylpyrrolidin-3-yl)piperazin-4-ium-1-yl]phenolate Preparation Products And Raw materials

Raw materials

Preparation Products

4-[4-(2,5-dioxo-1-phenylpyrrolidin-3-yl)piperazin-4-ium-1-yl]phenolate Suppliers

Global( 14)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	52927	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11289	58
Shanghai hongqu biomedical technology co. LTD	88888888888	hongquchem@qq.com	China	5132	58
Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd	15317229551	15151849396@163.com	China	997	58
ShangHai ChuanQian Chemcial Technique Centre	15869524721	3525679403@qq.com	China	3617	58
Beijing Jin Ming Biotechnology Co., Ltd.	010-60605840	psaitong@jm-bio.com	China	29778	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	24017	58
Nanjing Ningjitong Pharmaceutical Biotechnology Co., Ltd	0-19710401727 19710401727	3805829626@QQ.COM	China	497	58
Nantong Hanfang Biotechnology Co. , Ltd.	18616537568	hanfangpharma@126.com	China	30968	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
Aladdin Scientific	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	58
Shanghai hongqu biomedical technology co. LTD	58
Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd	58
ShangHai ChuanQian Chemcial Technique Centre	58
Beijing Jin Ming Biotechnology Co., Ltd.	58
TargetMol Chemicals Inc.	58
Nanjing Ningjitong Pharmaceutical Biotechnology Co., Ltd	58
Nantong Hanfang Biotechnology Co. , Ltd.	58

4-[4-(2,5-dioxo-1-phenylpyrrolidin-3-yl)piperazin-4-ium-1-yl]phenolate Spectrum

4-[4-(2,5-dioxo-1-phenylpyrrolidin-3-yl)piperazin-4-ium-1-yl]phenolate(522649-59-8)¹HNMR

4-[4-(2,5-dioxo-1-phenylpyrrolidin-3-yl)piperazin-4-ium-1-yl]phenolate Malic Enzyme inhibitor ME1 2,5-Pyrrolidinedione, 3-[4-(4-hydroxyphenyl)-1-piperazinyl]-1-phenyl- Malic enzyme inhibitor ME1 (Synonyms: ME1) 522649-59-8