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ChemicalBook >> CAS DataBase List >>1H-Benzimidazole-6-carboxylic acid, 2-[1-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-piperidinyl]-, methyl ester

1H-Benzimidazole-6-carboxylic acid, 2-[1-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-piperidinyl]-, methyl ester

1H-Benzimidazole-6-carboxylic acid, 2-[1-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-piperidinyl]-, methyl ester Structure
1H-Benzimidazole-6-carboxylic acid, 2-[1-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-piperidinyl]-, methyl ester structure
CAS No.
2097938-51-5
Chemical Name:
1H-Benzimidazole-6-carboxylic acid, 2-[1-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-piperidinyl]-, methyl ester
Synonyms
R-10015,inhibit,R10015,Inhibitor,LIMKs,Reverse Transcriptase,LIM Kinase (LIMK),R 10015;methyl 2-(1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-yl)-1H-benzo[d]imidazole-6-carboxylate;Methyl 2-(1-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-yl)-1H-benzo[d]imidazole-6-carboxylate;Methyl 2-(1-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-yl)-1H-benzo[d]imidazole-5-carboxylate;1H-Benzimidazole-6-carboxylic acid, 2-[1-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-piperidinyl]-, methyl ester
CBNumber:
CB24657880
Molecular Formula:
C20H19ClN6O2
Molecular Weight:
410.86
MDL Number:
MFCD32067935
MOL File:
2097938-51-5.mol
Last updated:2024-07-02 08:55:03
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1H-Benzimidazole-6-carboxylic acid, 2-[1-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-piperidinyl]-, methyl ester Properties

Density 1.465±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 62.5 mg/mL (152.12 mM; Need ultrasonic)
form Solid
pka 10.68±0.10(Predicted)
color Off-white to pink

1H-Benzimidazole-6-carboxylic acid, 2-[1-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-piperidinyl]-, methyl ester price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0069491 R-10015 99.72% 2097938-51-5 5mg $350 2021-12-16 Buy
ChemScene CS-0069491 R-10015 99.72% 2097938-51-5 50mg $1650 2021-12-16 Buy
DC Chemicals DC11706 R-10015 >98% 2097938-51-5 1g $2600 2021-12-16 Buy
Product number Packaging Price Buy
CS-0069491 5mg $350 Buy
CS-0069491 50mg $1650 Buy
DC11706 1g $2600 Buy

1H-Benzimidazole-6-carboxylic acid, 2-[1-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-piperidinyl]-, methyl ester Chemical Properties,Uses,Production

Biological Activity

R-10015 is a potent and selective LIM domain kinase (LIMK) inhibitor with IC50 of 38 nM for human LIMK1. It binds to the ATP-binding pocket and acts as a broad-spectrum antiviral compound for HIV infection.

in vitro

R-10015 (100 μM; 0-4 hours) inhibits cofilin phosphorylation directly through blocking LIM kinase in CEM-SS T cells.
R-10015 inhibits HIV-1 DNA synthesis, nuclear migration, and virion release.
R-10015 inhibits multiple viruses, including Zaire ebolavirus (EBOV), Rift Valley fever virus (RVFV), Venezuelan equine encephalitis virus (VEEV), and herpes simplex virus 1 (HSV-1) .< br/>

Western Blot Analysis

< td class="col1"> Result:
Cell Line: CEM-SS T cells
Concentration: 100 μM
Incubation Time: 0 hour,0.5 hour,1 hour,2 hours,4 hours
Inhibited cofilin phosphorylation directly through blocking LIM kinase in CEM-SS T cells.

in vivo

R-10015 (10 mg/kg; ip) displays no indication of toxicity. The result suggests the possibility of short-term use of LIMK inhibitors to block viral infections.

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Animal Model: 6-8 weeks female C3H/HeN mice
Dosage: 10 mg/kg
Administration: Intraperitoneal injection
Result: Displayed none indication of toxicity.

target

TargetValue
hLIMK1
(Cell-free assay)		 38 nM

1H-Benzimidazole-6-carboxylic acid, 2-[1-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-piperidinyl]-, methyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

1H-Benzimidazole-6-carboxylic acid, 2-[1-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-piperidinyl]-, methyl ester Suppliers

Global( 37)Suppliers
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ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32760 60
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Career Henan Chemica Co 		+86-0371-86658258 +8613203830695 laboratory@coreychem.com China 30250 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 57511 58
Shanghai Rechem science Co., Ltd. 21-31433387 15618786686 sales@rechemscience.com China 2972 58
Shanghai Chaolan Chemical Technology Center QQ:65489617 15618227136 info@SuperLan-chem.com China 9941 58
Shanghai SuperLan Chemcial Technique Centre 021-2022843681 15618226720 chaolaichem@foxmail.com China 9082 58
Beijing Solarbio Science & Tecnology Co., Ltd. 010-50973130 4009686088 3193328036@qq.com China 29786 68
Beijing Jin Ming Biotechnology Co., Ltd. 010-60605840 18892239720 psaitong@jm-bio.com China 12308 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
TargetMol Chemicals Inc. 		58
Career Henan Chemica Co 		58
InvivoChem 		58
Aladdin Scientific 		58
Shanghai Rechem science Co., Ltd. 58
Shanghai Chaolan Chemical Technology Center 58
Shanghai SuperLan Chemcial Technique Centre 58
Beijing Solarbio Science & Tecnology Co., Ltd. 68
Beijing Jin Ming Biotechnology Co., Ltd. 58
1H-Benzimidazole-6-carboxylic acid, 2-[1-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-piperidinyl]-, methyl ester Methyl 2-(1-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-yl)-1H-benzo[d]imidazole-5-carboxylate methyl 2-(1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-yl)-1H-benzo[d]imidazole-6-carboxylate Methyl 2-(1-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-yl)-1H-benzo[d]imidazole-6-carboxylate R-10015,inhibit,R10015,Inhibitor,LIMKs,Reverse Transcriptase,LIM Kinase (LIMK),R 10015 2097938-51-5