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T-025

T-025 Structure
T-025 structure
CAS No.
2407433-00-3
Chemical Name:
T-025
Synonyms
T-025;T025,T-025;N2-Methyl-N4-(pyrimidin-2-ylmethyl)-5-(quinolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine;7H-Pyrrolo[2,3-d]pyrimidine-2,4-diamine, N2-methyl-N4-(2-pyrimidinylmethyl)-5-(6-quinolinyl)-
CBNumber:
CB24668567
Molecular Formula:
C21H18N8
Molecular Weight:
382.42
MDL Number:
MFCD31813666
MOL File:
2407433-00-3.mol
Last updated:2024-07-02 08:55:03
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T-025 Properties

Density 1.432±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 8.25 mg/mL (21.57 mM; Need ultrasonic)
pka 13.45±0.50(Predicted)
form Solid
color Yellow to green

T-025 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0044754 T025 98.61% 2407433-00-3 5mg $450 2021-12-16 Buy
Product number Packaging Price Buy
CS-0044754 5mg $450 Buy

T-025 Chemical Properties,Uses,Production

Biological Activity

T025 is an orally active and highly potent inhibitor of Cdc2-like kinase (CLKs), with Kd values of 4.8, 0.096, 6.5, 0.61, 0.074, 1.5 and 32 nM for CLK1, CLK2, CLK3, CLK4, DYRK1A, DYRK1B and DYRK2, respectively. T025 induces caspase-3/7-mediated cell apoptosis. T025 reduces CLK-dependent phosphorylation. T025 exerts anti-proliferative activities in both hematological and solid cancer cell lines (IC50 values: 30-300 nM). T025 has an anti-tumor efficiency, mainly for MYC-driven disease research[1]. T025 (0-1000 nM; 72 hours) significantly suppresses the growth of MDA-MB-468 cells in a dose-dependent manner[1].T025 (0-1000 nM; 6 hours) reduces phosphorylation levels in MDA-MB-468 cells[1]. T025 (50 mg/kg; p.o.; 2, 4, 8 hours, Balb/c nude mice (7 to 8 week-old females).) suppress the CLK-dependent phosphorylation and induce skipping exon in various genes[1]. T025 (50 mg/kg; p.o.; twice daily on 2 days per week, for 3 weeks, Balb/c nude mice (7 to 8 week-old females).) inhibits MDA-MB-468 xenograft mice tumor growth and without affect body weight [1].

References

[1]. Iwai K, et al. Anti-tumor efficacy of a novel CLK inhibitor via targeting RNA splicing and MYC-dependent vulnerability. EMBO Mol Med. 2018 Jun;10(6):e8289.

T-025 Preparation Products And Raw materials

Raw materials

Preparation Products

T-025 Suppliers

Global( 14)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4264 55
Tianjin Kailiqi Biotechnology Co., Ltd. 15076683720 klq@cw-bio.com China 3730 55
Shanghai hongqu biomedical technology co. LTD 88888888888 hongquchem@qq.com China 5132 58
Chunchuang (Wuhan) Technology Co., Ltd 15342225168 yutianchun2007@126.com China 10004 58
cjbscvictory 13348960310 13348960310 3003867561@qq.com China 10000 58
Bide Pharmatech Ltd. 400-1647117 15221909166 product02@bidepharm.com China 63720 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 23963 58
Shanghai Tachizaki Biomedical Research Center 18014399201 sales@chemlab-tachizaki.com China 2539 58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. 025-66113011 18112977050 cb5@aikonchem.com China 10529 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
Shanghai Lollane Biological Technology Co.,Ltd. 55
Tianjin Kailiqi Biotechnology Co., Ltd. 55
Shanghai hongqu biomedical technology co. LTD 58
Chunchuang (Wuhan) Technology Co., Ltd 58
cjbscvictory 58
Bide Pharmatech Ltd. 58
TargetMol Chemicals Inc. 58
Shanghai Tachizaki Biomedical Research Center 58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. 58
T-025 T025,T-025 7H-Pyrrolo[2,3-d]pyrimidine-2,4-diamine, N2-methyl-N4-(2-pyrimidinylmethyl)-5-(6-quinolinyl)- N2-Methyl-N4-(pyrimidin-2-ylmethyl)-5-(quinolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine 2407433-00-3