TVB-3166
- CAS No.
- 1533438-83-3
- Chemical Name:
- TVB-3166
- Synonyms
- TVB-3166;TVB-3166,TVB3166;TVB-3166 >=98% (HPLC);TVB 3166,inhibit,TVB3166,Apoptosis,TVB-3166,Inhibitor,Fatty Acid Synthase (FASN);4-(1-(5-(4,5-Dimethyl-1H-pyrazol-3-yl)-2,4-dimethylbenzoyl)azetidin-3-yl)benzonitrile;Benzonitrile, 4-[1-[5-(4,5-dimethyl-1H-pyrazol-3-yl)-2,4-dimethylbenzoyl]-3-azetidinyl]-
- CBNumber:
- CB24670650
- Molecular Formula:
- C24H24N4O
- Molecular Weight:
- 384.47
- MDL Number:
- MOL File:
- 1533438-83-3.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H302-H315-H319-H335 |
Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
TVB-3166 price More Price(6)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | SML1694 | TVB-3166 ≥98% (HPLC) | 1533438-83-3 | 5MG | $131 | 2023-06-20 | Buy |
Sigma-Aldrich | SML1694 | TVB-3166 ≥98% (HPLC) | 1533438-83-3 | 25MG | $530 | 2023-06-20 | Buy |
ChemScene | CS-0077865 | TVB-3166 99.55% | 1533438-83-3 | 50mg | $590 | 2021-12-16 | Buy |
ChemScene | CS-0077865 | TVB-3166 99.55% | 1533438-83-3 | 100mg | $990 | 2021-12-16 | Buy |
ChemScene | CS-0077865 | TVB-3166 99.55% | 1533438-83-3 | 10mg | $170 | 2021-12-16 | Buy |
TVB-3166 Chemical Properties,Uses,Production
Biochem/physiol Actions
TVB-3166 is a cell-permeable pyrrazole derivative that inhibits cellular palmitate synthesis (IC50 <100 nM) by fatty acid synthase (FASN) keto-reductase activity in a potent and reversible manner (IC50 = 42 nM), effectively inhibiting palmitate-dependent survival of various cancer cells in cultures and xenografted tumor growth in mice vivo (60-100 mg/kg/d p.o.), while exhibiting little or no anti-proliferation activity toward non-palmitate-dependent growth of cancer and non-cancer cultures. FASN inhibition by TVB-3166 treatment is also effective against the replications respiratory viruses both in cultures (Effc. conc. 200 nM against RSV and PIV3 in A549, HEp2, and HeLa cultures) and in mice (50 mg/kg/12 h, p.o.; RSV) in vivo without significant adverse effects to the host cells or mice.
TVB-3166 Preparation Products And Raw materials
Raw materials
Preparation Products
TVB-3166 Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4428 | 55 |
Shanghai XingMo Biotechnology Co., Ltd. | 13524779951 | 2075692521@qq.com | China | 310 | 55 |
Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696,15000506266 15000506266 | China | 4217 | 55 | |
Shanghai Chaolan Chemical Technology Center | QQ:65489617 15618227136 | info@SuperLan-chem.com | China | 9874 | 58 |
Shanghai Han-Xiang Chemical Co., Ltd. | 15971444841 | amber@biochempartner.com | China | 3063 | 58 |