Thiamine nitrate
- CAS No.
- 532-43-4
- Chemical Name:
- Thiamine nitrate
- Synonyms
- THIAMINE MONONITRATE;Vitamin B1 Mono;Thiamin Mononitrate;ThiaMine Monohydrate;VITAMIN B1 NITRATE;vitamin Bl mononitrate;VITAMIN B1 MONONITRATE;D03277;Vitanon;mnitrate
- CBNumber:
- CB2472353
- Molecular Formula:
- C12H17N5O4S
- Molecular Weight:
- 327.36
- MDL Number:
- MFCD00036330
- MOL File:
- 532-43-4.mol
- MSDS File:
- SDS
| Melting point | 374-392 °C |
|---|---|
| storage temp. | 2-8°C |
| solubility | Sparingly soluble in water, freely soluble in boiling water, slightly soluble in alcohol and in methanol. |
| form | solid |
| pka | 4.8(at 25℃) |
| color | White to Off-White |
| Odor | wh. cryst. or cryst. powd., sl. char. odor |
| Merck | 14,9295 |
| BRN | 3857790 |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| InChI | InChI=1S/C12H17N4OS.NO3/c1-8-11(3-4-17)18-7-16(8)6-10-5-14-9(2)15-12(10)13;2-1(3)4/h5,7,17H,3-4,6H2,1-2H3,(H2,13,14,15);/q+1;-1 |
| InChIKey | UIERGBJEBXXIGO-UHFFFAOYSA-N |
| SMILES | [N+]1(CC2=CN=C(C)N=C2N)C(C)=C(SC=1)CCO.[N+]([O-])([O-])=O |
| FDA 21 CFR | 184.1878; 582.5878 |
| Substances Added to Food (formerly EAFUS) | THIAMINE MONONITRATE |
| SCOGS (Select Committee on GRAS Substances) | Thiamine mononitrate |
| CAS DataBase Reference | 532-43-4(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 8K0I04919X |
| EPA Substance Registry System | Thiamine nitrate (532-43-4) |
SAFETY
Risk and Safety Statements
| Safety Statements | 22-24/25 |
|---|---|
| WGK Germany | 1 |
| RTECS | XI7400000 |
| TSCA | Yes |
| HS Code | 29362200 |
Thiamine nitrate price More Price(27)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PHR1337 | Thiamine Nitrate Pharmaceutical Secondary Standard; Certified Reference Material | 532-43-4 | 1g | $94.3 | 2024-03-01 | Buy |
| Sigma-Aldrich | BP414 | Thiamine mononitrate British Pharmacopoeia (BP) Reference Standard | 532-43-4 | 100MG | $269 | 2024-03-01 | Buy |
| TCI Chemical | T0182 | Thiamine Nitrate >98.0%(HPLC)(E) | 532-43-4 | 25g | $83 | 2024-03-01 | Buy |
| TCI Chemical | T0182 | Thiamine Nitrate >98.0%(HPLC)(E) | 532-43-4 | 100g | $173 | 2024-03-01 | Buy |
| Alfa Aesar | J60014 | Thiamine nitrate | 532-43-4 | 10g | $44.1 | 2024-03-01 | Buy |
Thiamine nitrate Chemical Properties,Uses,Production
Description
Thiamine nitrate is the thiamine salt formed from one mole of thiamine base and one mole of nitric acid. It occurs as an anhydrous crystalline solid of low hygroscopicity. Thiamin (vitamin B1) is a member of the vitamin B complex. Attributing to low hydroscopicity, thiamine nitrate works as a more stable form of thiamine in pharmaceutical preparations.
Thiamine nitrate is preferred to be used for the preparation of multivitamins and as a food fortification in dry blends and dry products such as in wheat flour.
References
[1] Food and Agriculture Organization of the United Nations, Food Fortification: Technology and Quality Control: Report of an FAO technical meeting Rome, 1995
[2] Ronald R. Eitenmiller, W. O. Landen Jr and Lin Ye, Vitamin Analysis for the Health and Food Sciences, Second Edition, 2008
[3] Thomas J. Macek, Beate A. Feller and Edward J. Hanus, Pharmaceutical studies with thiamine mononitrate, Journal of Pharmaceutical Sciences, 1950, vol. 39, 365-369
Description
Thiamine is a water-soluble vitamin with antioxidant, neuroprotective, and anxiolytic properties. It inhibits lipid peroxidation in rat liver microsomes and free radical oxidation of oleic acid in vitro when used at concentrations ranging from 1 to 100 μM. In vivo, thiamine (100 mg/kg) reduces hepatic levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT), lipid peroxidation, and protein damage in a rat model of acute ethanol intoxication. It reverses predator stress-induced suppression of hippocampal neurogenesis and decreases the latency of step-down from a platform, indicating anxiolytic-like activity in mice. Thiamine (8.5 mg/100 g food) reduces neurodegeneration and increases survival in Slc19a3-/- mice, a model of thiamine metabolism dysfunction syndrome-2 (THMD-2).
Chemical Properties
White or almost white, crystalline powder or small, colourless crystals.
Uses
Vitamin B1.
Uses
Thiamine Nitrate is an orally administered vitamin. Thiamine is a essential nutrient required for carbohydrate metabolism and is involved in nerve function.
benefits
Some of the critical uses and benefits of Vitamin B1 Mononitrate(Thiamine nitrate) include:
Supports Energy production: Thiamine nitrate is involved in converting food into energy, particularly in the metabolism of carbohydrates.
Helps Nervous system: Thiamine nitrate is essential for proper nervous system function and is involved in transmitting nerve impulses.
Improves Cardiovascular health: Thiamine nitrate is important for maintaining healthy heart function, and may help to reduce the risk of heart disease.
Supports Appetite regulation: Vitamin B1 mononitrate is involved in regulating appetite and may help to reduce the risk of overeating and weight gain.
Improves Eye health: Thiamine nitrate is involved in maintaining healthy eye function, and may help to reduce the risk of certain eye disorders.
General Description
Certified pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Thiamine Nitrate is a mononitrate salt of thiamine. It is synthesized from thiamine hydrochloride following a sequence of steps. Thiamine Nitrate is used as a dietary supplement in crackers, eggs substitute and enriched flour.
Safety Profile
Poison by intravenous and intraperitoneal routes. A powerful oxidizer. When heated to decomposition it emits very toxic fums of SOx, and NOx. See also NITRATES.
Thiamine nitrate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Aurora Industry Co., Ltd. | +86-13591747876 +86-13591747876 | alex1_auco@126.com | China | 277 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 5857 | 58 |
| Wuhan Fortuna Chemical Co., Ltd | +86-027-59207850 | info@fortunachem.com | China | 5975 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5889 | 58 |
| airuikechemical co., ltd. | +undefined86-15315557071 | sales02@sdzhonghuimaterial.com | China | 983 | 58 |
| Shaanxi TNJONE Pharmaceutical Co., Ltd | +8618092446649 | sarah@tnjone.com | China | 1143 | 58 |
| Hebei Zhuanglai Chemical Trading Co Ltd | +86-16264648883 +86-16264648883 | niki@zlchemi.com | China | 2397 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21634 | 55 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418679 +8618949832763 | info@tnjchem.com | China | 2986 | 55 |
| Tianjin Zhongxin Chemtech Co., Ltd. | +86-022-66880623 +8618622897568 | sales@tjzxchem.com | China | 563 | 58 |
View Lastest Price from Thiamine nitrate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-12-18 | vitamin B1 mono
532-43-4
|
US $0.00 / Kg/Bag | 2Kg/Bag | 99% up, High Density | 20 tons | Sinoway Industrial co., ltd. | |
 |
2024-12-18 | Thiamine nitrate
532-43-4
|
US $150.00 / kg | 1kg | 99% | 500kg | Hebei Zhuanglai Chemical Trading Co Ltd | |
 |
2024-12-13 | Thiamine nitrate
532-43-4
|
US $0.00-0.00 / kg | 1kg | 98%-101%; BP/USP | 1000KGS | WUHAN FORTUNA CHEMICAL CO., LTD |
-
- vitamin B1 mono
532-43-4
- US $0.00 / Kg/Bag
- 99% up, High Density
- Sinoway Industrial co., ltd.
-
- Thiamine nitrate
532-43-4
- US $150.00 / kg
- 99%
- Hebei Zhuanglai Chemical Trading Co Ltd
-
- Thiamine nitrate
532-43-4
- US $0.00-0.00 / kg
- 98%-101%; BP/USP
- WUHAN FORTUNA CHEMICAL CO., LTD