1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine
- CAS No.
- 4004-05-1
- Chemical Name:
- 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine
- Synonyms
- DOPE;1,2-Dioleoyl-sn-glycero-3-PE;(Z)-(2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dioleate;18:1 PE;PE(18:1(9Z)/18:1(9Z));COATSOME ME-8181 (DOPE);L-β,γ-Dioleoyl-α-cephalin;L-β,γ-Dioleoyl-α-Cephalin;18:1 (Delta9-Cis) PE (DOPE);Dioleoyl phosphoethanolamine
- CBNumber:
- CB2477530
- Molecular Formula:
- C41H78NO8P
- Molecular Weight:
- 744.05
- MDL Number:
- MFCD16621009
- MOL File:
- 4004-05-1.mol
- MSDS File:
- SDS
| Melting point | 200°C(lit.) |
|---|---|
| Boiling point | 759.2±70.0 °C(Predicted) |
| Density | 1.008±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | DMSO: 31.25 mg/mL (42.00 mM) |
| form | lyophilized powder |
| pka | 1.17±0.50(Predicted) |
| color | White to Light yellow |
| BRN | 1718431 |
| InChIKey | MWRBNPKJOOWZPW-XFBMKQTANA-N |
| SMILES | [C@H](COP(O)(=O)OCCN)(COC(=O)CCCCCCC/C=C\CCCCCCCC)OC(=O)CCCCCCC/C=C\CCCCCCCC |&1:0,r| |
| FDA UNII | JNP6V6AI0U |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS06,GHS08 |
|---|---|
| Signal word | Danger |
| Hazard statements | H302-H315-H319-H331-H336-H351-H361d-H372-H412 |
| Precautionary statements | P201-P273-P301+P312+P330-P302+P352-P304+P340+P311-P308+P313 |
| Hazard Codes | Xn |
| Risk Statements | 22-38-40-48/20/22-67-36/38-20-63 |
| Safety Statements | 36/37-26 |
| RIDADR | UN 1888 6.1/PG 3 |
| WGK Germany | 3 |
| F | 8-10-23 |
| HS Code | 29232000 |
1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine price More Price(29)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 42490 | 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine ≥99.0% (10 mg phospholipid per ml CHCl3, TLC) | 4004-05-1 | 2.5ml | $87.6 | 2024-03-01 | Buy |
| Sigma-Aldrich | 42490 | 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine ≥99.0% (10 mg phospholipid per ml CHCl3, TLC) | 4004-05-1 | 10ml | $327 | 2024-03-01 | Buy |
| TCI Chemical | D4251 | 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine >98.0%(T) | 4004-05-1 | 250mg | $254 | 2024-03-01 | Buy |
| Cayman Chemical | 15091 | 1,2-Dioleoyl-sn-glycero-3-PE ≥98% | 4004-05-1 | 100mg | $81 | 2024-03-01 | Buy |
| Cayman Chemical | 15091 | 1,2-Dioleoyl-sn-glycero-3-PE ≥98% | 4004-05-1 | 250mg | $120 | 2024-03-01 | Buy |
1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine Chemical Properties,Uses,Production
Description
1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) is a neutral phospholipid and displays sensitivity towards pH change and has been used in the preparation of liposome and giant unilamellar vesicles (GUVs).
Phosphatidylethanolamine (PE) is formed primarily in the reaction of CDP-ethanolamine and diacylglycerol. PE is one of the major components of cell membranes in bacteria and in nervous system.
Chemical Properties
Yellowish wax
Uses
18:1 (Δ9-Cis) PE (DOPE) has been used in the preparation of liposome for human uncoupling protein 1 (UCP1) reconstitution and for Caenorhabditis elegans autophagy related cysteine protease protein conjugation studies. It has also been used for the generation of giant unilamellar vesicles (GUVs) for septin induced deformation studies.
Uses
1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) forms heterogenous liposomes with N-[1-(2,3-dioleoyloxy)propyl]-N,N,N-trimethylammonium methylsulfate (DOTAP), which are used as delivery vehicles for therapeutic agents.
Uses
1,2-Dioleoyl-sn-glycero-3-phosphatidylethanolamine (DOPE) is a synthetic analog of naturally-occurring PE containing 18:1 fatty acids at the sn-1 and sn-2 positions. DOPE can be used as an emulsifier to facilitate DNA-liposome complex transport across membranes. It is used in combination with cationic phospholipids to increase efficiency during DNA transfection studies as a non-viral method of gene delivery.
Definition
ChEBI: Dioleoyl phosphatidylethanolamine is a phosphatidylethanolamine in which the phosphatidyl acyl groups are both oleoyl.
General Description
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (18:1 (Δ9-Cis) PE (DOPE)) is a neutral phospholipid and displays sensitivity towards pH change. At acidic it is an inverted hexagonal micelle and transforms to spherical micelle at alkaline pH.
Biological Activity
DOPE in mixed membranes have been found to decrease fluorescence lifetime and increase acyl-chain order. DOPE is an essential component of cationic liposomes designed to deliver DNA into gliosarcoma and kidney cell lines (gene therapy).
Biochem/physiol Actions
DOPE in mixed membranes have been found to decrease fluorescence lifetime and increase acyl-chain order. DOPE is an essential component of cationic liposomes designed to deliver DNA into gliosarcoma and kidney cell lines (gene therapy).
storage
Store at -20°C
1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| XIAMEN SINOPEG BIOTECH CO., LTD. | +86-0592-7761068 +8617350879715 | changaiwei@sinopeg.com | China | 176 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12841 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 5857 | 58 |
| Hebei Weibang Biotechnology Co., Ltd | +8617732866630 | bess@weibangbio.com | China | 18153 | 58 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 18774 | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8497 | 58 |
| Shandong chuangyingchemical Co., Ltd. | 18853181302 | sale@chuangyingchem.com | CHINA | 5906 | 58 |
| Shochem(Shanghai) Co.,Ltd | 86-21-50800795 | info@shochem.com | CHINA | 288 | 58 |
| Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | sale04@alfachem.cn | China | 13415 | 58 |
Related Qustion
- Q:What is 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine?
- A:1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) is a metabolite of Escherichia coli with a structure containing 18:1 fatt....
- Mar 14，2024
View Lastest Price from 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-19 | DOPE
4004-05-1
|
US $97.00 / mg | 97.23% | 10g | TargetMol Chemicals Inc. | ||
 |
2024-10-25 | 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine
4004-05-1
|
US $30.00-1.00 / kg | 1kg | 0.99 | 3 tons | Hebei Yanxi Chemical Co., Ltd. | |
 |
2024-10-24 | 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine
4004-05-1
|
US $0.00-0.00 / KG | 1KG | 99% | 500000kg | Hebei Weibang Biotechnology Co., Ltd |
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- DOPE
4004-05-1
- US $97.00 / mg
- 97.23%
- TargetMol Chemicals Inc.
-
- 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine
4004-05-1
- US $30.00-1.00 / kg
- 0.99
- Hebei Yanxi Chemical Co., Ltd.
-
- 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine
4004-05-1
- US $0.00-0.00 / KG
- 99%
- Hebei Weibang Biotechnology Co., Ltd
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