DC661
- CAS No.
- 1872387-43-3
- Chemical Name:
- DC661
- Synonyms
- DC661;DC-661;DC 661;inhibit,Inhibitor,Autophagy,Apoptosis,DC-661,DC 661,DC661;N'-(7-Chloro-4-quinolinyl)-N-{6-[(7-chloro-4-quinolinyl)amino]hexyl}-N-methyl-1,6-hexanediamine;N1-(7-Chloroquinolin-4-yl)-N6-(6-((7-chloroquinolin-4-yl)amino)hexyl)-N6-methylhexane-1,6-diamine;1,6-Hexanediamine, N6-(7-chloro-4-quinolinyl)-N1-[6-[(7-chloro-4-quinolinyl)amino]hexyl]-N1-methyl-
- CBNumber:
- CB24800859
- Molecular Formula:
- C31H39Cl2N5
- Molecular Weight:
- 552.58
- MDL Number:
- MFCD31812586
- MOL File:
- 1872387-43-3.mol
DC661 price
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Biorbyt Ltd | orb573232 | DC661 >98% | 1872387-43-3 | 100mg | $1208.7 | 2021-12-16 | Buy |
Biorbyt Ltd | orb573232 | DC661 >98% | 1872387-43-3 | 250mg | $1802 | 2021-12-16 | Buy |
Biorbyt Ltd | orb573232 | DC661 >98% | 1872387-43-3 | 1g | $3580.2 | 2021-12-16 | Buy |
DC Chemicals | DC12554 | DC661 >98% | 1872387-43-3 | 1g | $2400 | 2021-12-16 | Buy |
DC Chemicals | DC12554 | DC661 >98% | 1872387-43-3 | 100mg | $800 | 2021-12-16 | Buy |
DC661 Chemical Properties,Uses,Production
Biological Activity
DC661 is able to deacidify lysosomes and significantly inhibit autophagy, which is more effective than hydroxychloroquine (HCQ). It induces apoptosis.
in vitro
Treatment of melanoma cells with DC661 induced the accumulation of the autophagic vacuole marker LC3B-II, which was more pronounced and lower than that of Lys05 or HCQ. At concentrations of it greater than 10 μM, all cells died. Compared with HCQ and Lys05, DC661 inhibited autophagic flux more significantly in melanoma cells expressing the mCherry-eGFP-LC3B reporter gene; in melanoma cells expressing the GFP-LC3B reporter gene, the expression level was higher of free GFP levels. It can cause a more pronounced lysosomal deacidification effect. In a variety of cancer cell lines, including colon and pancreatic cancer cells, the IC50 of DC661 was 100-fold lower than that of HCQ as measured by MTT assay after 72 hours of drug incubation. In BRAF-mutated melanoma cell lines, it inhibited the clonal growth of long-term melanoma cells more effectively and induced more apoptosis than Lys05, HCQ or BRAF/MEK dual inhibition conditions.
in vivo
In the HT29 xenograft model, intraperitoneal injection of 3 mg/kg DC661 caused a significant decrease in tumor volume, and the daily tumor growth rate was completely inhibited several times. but did not affect the body weight of mice.
target
Target | Value | ||||
Autophagy () |
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32836 | 60 |
HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
Chemia Biotechnology(Shanghai) Co., Ltd | +8613816753574 | info@chemia-pharm.com | CHINA | 311 | 58 |
Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10522 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
Nanjing Doge Biomedical Technology Co., Ltd | +86-25-58227606 +86-15305155328 | sales@dogechemical.com | China | 4128 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7887 | 56 |
Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696,15000506266 15000506266 | China | 4309 | 55 |