MDL-800 (MDL800)
- CAS No.
- 2275619-53-7
- Chemical Name:
- MDL-800 (MDL800)
- Synonyms
- Benzoic acid, 2-[[(5-bromo-4-fluoro-2-methylphenyl)amino]sulfonyl]-5-[[(3,5-dichlorophenyl)sulfonyl]amino]-, methyl ester;MDL-800 (MDL800);Methyl 2-(N-(5-bromo-4-fluoro-2-methylphenyl)sulfamoyl)-5-(3,5-dichlorophenylsulfonamido)benzoate
- CBNumber:
- CB24845018
- Molecular Formula:
- C21H16BrCl2FN2O6S2
- Molecular Weight:
- 626.3
- MDL Number:
- MFCD31813709
- MOL File:
- 2275619-53-7.mol
| Boiling point | 714.8±70.0 °C(Predicted) |
|---|---|
| Density | 1.710±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | Soluble in DMSO (up to at least 10 mg/ml with warming) |
| pka | 4.96±0.10(Predicted) |
| form | solid |
| color | White |
| Stability | Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
MDL-800 (MDL800) price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | BISN0090 | MDL-800 99% | 2275619-53-7 | 1mg | $399 | 2021-12-16 | Buy |
| Apolloscientific | BISN0090 | MDL-800 99% | 2275619-53-7 | 5mg | $704 | 2021-12-16 | Buy |
| Apolloscientific | BISN0090 | MDL-800 99% | 2275619-53-7 | 10mg | $1052 | 2021-12-16 | Buy |
MDL-800 (MDL800) Chemical Properties,Uses,Production
Description
MDL-800 (2275619-53-7) is an allosteric activator of SIRT6 (EC50 = 10.3 μM).1 It specifically activates the deacetylase (H3K9ac and H3K56ac) activity of SIRT6 – inactive against SIRT1,3,4 and HDACs 1-11 with 10x less activity against SIRT2,5,7. It inhibited the growth of human hepatocarcinoma cells (HCC) via the tumor suppressor deacetylase (H3K9ac and H3K56ac) via cell-cycle arrest and showed efficacy in a xenograft model of HCC.? MDL-800 improved the genetic stability of old-murine-derived iPSCs via activation of NHEJ and BER DNA repair pathways suggesting promise in treating age-related diseases via iPSC-based therapies.2 MDL-800 inhibited the proliferation of 12 non-small cell lung carcinoma cell lines with IC50 values of 21.5 to 34.5 μM.3 It also enhanced the effects of EGFR kinase inhibitors in Osimertinib-resistant HCC827 and PC9 cells as well as in patient-derived primary tumor cells.3
References
Huang et al. (2018) Identification of a cellularly active SIRT6 allosteric activator; Chem. Biol.?14 1118 Chen et al. (2020) The SIRT6 activator MDL-800 improves genomic stability and pluripotency of old murine-derived iPS cells; Aging Cell?19 e13185 Shang et al. (2021) MDL-800, an allosteric activator of SIRT6, suppresses proliferation and enhances EGFR-TKIs therapy in non-small cell lung cancer; Acta Pharmacol. Sin.?42 120
MDL-800 (MDL800) Preparation Products And Raw materials
Raw materials
Preparation Products
MDL-800 (MDL800) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
| Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd | +86-18341751992 +86-15382112998 | 757984502@qq.com | China | 892 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | product@acmec-e.com | China | 33350 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4252 | 55 | |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9707 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 27322 | 60 |
| MQ (shanghai) Pharmaceuticals Co., Ltd. | 13761635123 | 1014988033@qq.com | China | 4992 | 55 |
| DC Chemicals | 021-58447131 13564518121 | sales@dcchemicals.com | China | 9412 | 58 |
| Shanghai Luofa Biochemical Technology Co., Ltd. | 021-51111890 15317326293 | sales@molnova.com | China | 4196 | 58 |
| ShangHai ChuanQian Chemcial Technique Centre | 15869524721 | 3525679403@qq.com | China | 3670 | 58 |