PS10
- CAS No.
- 1564265-82-2
- Chemical Name:
- PS10
- Synonyms
- PS10;PS10,PS-10;2-[(24-Dihydroxyphenyl)sulfonyl]-23-dihydro-1H-isoindole-46-diol;1H-Isoindole-4,6-diol, 2-[(2,4-dihydroxyphenyl)sulfonyl]-2,3-dihydro-
- CBNumber:
- CB24866400
- Molecular Formula:
- C14H13NO6S
- Molecular Weight:
- 323.32
- MDL Number:
- MFCD31814433
- MOL File:
- 1564265-82-2.mol
PS10 price
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
ChemScene | CS-0083143 | PS10 99.26% | 1564265-82-2 | 5mg | $100 | 2021-12-16 | Buy |
ChemScene | CS-0083143 | PS10 99.26% | 1564265-82-2 | 10mg | $180 | 2021-12-16 | Buy |
ChemScene | CS-0083143 | PS10 99.26% | 1564265-82-2 | 50mg | $670 | 2021-12-16 | Buy |
ChemScene | CS-0083143 | PS10 99.26% | 1564265-82-2 | 100mg | $1100 | 2021-12-16 | Buy |
PS10 Chemical Properties,Uses,Production
Enzyme inhibitor
This novel ATP binding pocket-directed inhibitor (FW = 323.32 g/mol), systematically named 2-[(2,4-dihydroxyphenyl)sulfonyl]isoindoline-4,6- diol, targets all four PDK isoforms, with an IC50 = 0.8 μM and Ki = 0.24 μM for PDK2. Its design is based on structure-guided design, converting a known Hsp90 inhibitor into a series of highly specific PDK inhibitors, substituting a sulfonyl group in place of a carbonyl in the parent compound. This modification results in weak binding to Hsp90 (Ki = 47 μM). PS10 administration (70 mg/kg) to diet-induced obese mice significantly augments PDC activity with reduced phosphorylation in different tissues. Prolonged treatment improves glucose tolerance, with notably lessened hepatic steatosis in a mouse model. Such findings suggest pharmacological targeting of PDK may be useful in controlling glucose and fat levels in obesity and type 2 diabetes.
PS10 Preparation Products And Raw materials
Raw materials
Preparation Products
PS10 Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7892 | 56 |
Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6870 | 58 |
ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
Jinan Jiuli Biotechnology Co. , Ltd. | 14768611851 | 486064515@qq.com | China | 2510 | 58 |
TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24017 | 58 |
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd | 021-59167510 18117107507 | vip@med-life.cn | China | 5014 | 58 |
RD International Technology Co., Limited | 18024082417 | market@ubiochem.com | China | 9282 | 58 |