dupilumab
- CAS No.
- 1190264-60-8
- Chemical Name:
- dupilumab
- Synonyms
- REGN-668;dupilumab;Dupliumab;SAR-231893;Research Grade Dupilumab(DHD62601)
- CBNumber:
- CB24919920
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
| form | Liquid |
|---|---|
| color | Colorless to light yellow |
| FDA UNII | 420K487FSG |
| NCI Drug Dictionary | dupilumab |
| ATC code | D11AH05 |
dupilumab price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0030874 | Dupilumab ≥99.2% | 1190264-60-8 | 1mg | $900 | 2021-12-16 | Buy |
| ChemScene | CS-0030874 | Dupilumab ≥99.2% | 1190264-60-8 | 5mg | $1800 | 2021-12-16 | Buy |
| ChemScene | CS-0030874 | Dupilumab ≥99.2% | 1190264-60-8 | 25mg | $9000 | 2021-12-16 | Buy |
dupilumab Chemical Properties,Uses,Production
Uses
Dupilumab, also known as Dupixent?, is a treatment for severe atopic eczema.
Mechanism of action
Biologics work by blocking ILs from binding to their cell receptors (protein molecules that receive chemical signals from outside a cell); this stops the immune system from overreacting. Dupilumab works on two specific ILs thought to contribute to atopic conditions: IL-4 and IL-13. By blocking IL-4 and IL-13 from binding to their cell receptors, dupilumab limits the overreaction of the immune system, dampening down the chronic inflammatory response and lessening the symptoms of atopic eczema.
Pharmacokinetics
Dupilumab shows a non-linear rate in regard to the target.Dupilumab is also reported to have a bioavailability of 64%, with the average concentration occurring one week after in one week after injection.
Side effects
The most common side effects reported by the US Food and Drug Administration (FDA) include injection site reactions, upper respiratory tract infections, joint pain, and herpes viral infections.The most common side effects reported by the European Medicines Agency (EMA) include injection-site reactions (such as redness, swelling including due to fluid build-up, itching and pain), conjunctivitis (redness and discomfort in the eye) including conjunctivitis due to allergy, joint pain, cold sores, and increased blood levels of a type of white blood cell called eosinophils.
dupilumab Preparation Products And Raw materials
Raw materials
Preparation Products
dupilumab Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 4692 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4197 | 55 | |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9708 | 58 |
| ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | 2853530910@QQ.com | China | 8018 | 62 |
| Shanghai Zhibang Biological Medicine Co., LTD | 021-54285032 18116461626 | 25493162@qq.com | China | 142 | 58 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9730 | 58 |
| BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
| Guangzhou Hongyuan Chemical Co.,Ltd | 15817493340 | 981810490@qq.com | China | 1565 | 58 |
| Wuhan Chemstan Biotechnology Co., Ltd. | 027-65317797 15926423062 | 422450190@qq.com | China | 10034 | 58 |