Sodium taurodeoxycholate hydrate
- CAS No.
- 207737-97-1
- Chemical Name:
- Sodium taurodeoxycholate hydrate
- Synonyms
- 5β12αsodium 2-[[(3αSodium taurodeoxycholate, ≥99%;SODIUM TAURODEOXYCHOLATE HYDRATE;N-(Deoxycholyl)taurine sodium salt;SODIUM TAURODEOXYCHOLATE HYDRATE BIO;Taurodeoxycholic acid sodium hydrate;Taurodeoxycholic Acid-[d6] Sodium Salt;2H6]-Taurodeoxycholic Acid Sodium Salt
- CBNumber:
- CB2547459
- Molecular Formula:
- C26H48NNaO7S
- Molecular Weight:
- 541.72
- MDL Number:
- MFCD00149238
- MOL File:
- 207737-97-1.mol
- MSDS File:
- SDS
| Melting point | 168 °C (dec.)(lit.) |
|---|---|
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | H2O: soluble0.5M, clear, colorless to faintly yellow |
| form | A crystalline solid |
| color | White to off-white |
| BRN | 3901204 |
| InChIKey | GFBBTUJLLSJWQW-RIIXSHNENA-N |
| SMILES | C[C@]12[C@H](C[C@]3([H])[C@]4(CC[C@@H](O)C[C@@]4([H])CC[C@@]3([H])[C@]1([H])CC[C@]2([H])[C@H](C)CCC(=O)NCCS(O)(=O)=O)C)O.[NaH].O |&1:1,2,4,6,9,12,16,18,22,24,r| |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H319-H315-H335 | |||||||||
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 29242998 | |||||||||
| NFPA 704 |
|
Sodium taurodeoxycholate hydrate price More Price(23)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | T0557 | Sodium taurodeoxycholate hydrate BioXtra, ≥97% (TLC) | 207737-97-1 | 1g | $84.7 | 2024-03-01 | Buy |
| Sigma-Aldrich | T0557 | Sodium taurodeoxycholate hydrate BioXtra, ≥97% (TLC) | 207737-97-1 | 5g | $247 | 2024-03-01 | Buy |
| Cayman Chemical | 15935 | Taurodeoxycholic Acid (sodium salt hydrate) ≥95% | 207737-97-1 | 1g | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 15935 | Taurodeoxycholic Acid (sodium salt hydrate) ≥95% | 207737-97-1 | 5G | $109 | 2024-03-01 | Buy |
| Cayman Chemical | 15935 | Taurodeoxycholic Acid (sodium salt hydrate) ≥95% | 207737-97-1 | 25g | $426 | 2024-03-01 | Buy |
Sodium taurodeoxycholate hydrate Chemical Properties,Uses,Production
Description
Sodium taurodeoxycholate hydrate is a bile salt-related, anionic detergent used for isolation of membrane proteins including inner mitochondrial membrane proteins. It has also been used in a study to investigate polymorphic behavior in protein surfactant mixtures.
Sodium taurodeoxycholate hydrate has been used in a study to assess the effect of submicellar concentrations of bile salts on the lipid bilayer membrane. It has also been used in a study to investigate polymorphic behavior in protein-surfactant mixtures.
Uses
A hydrate form of sodium taurodeoxycholate (T009005), a steroid which rescues human colon cancer cells from apoptosis by activating EGFR-dependent PI3K/Akt signaling.
General Description
Sodium tauroursodeoxycholate is a bile salt which is naturally present in the small bowel.
Purification Methods
The Na salt is dissolved in the smallest volume of H2O, a saturated solution of aqueous NaCl/Et2O is added and the mixture is stored at 0o for 24hours. Then shake the mixture well, keep it in the cold for another day and filter the crystals with gentle shaking, wash them with ice-cold saturated aqueous NaCl saturated with Et2O, dry them over CaCl2 and extract them with absolute EtOH. Add ~10mL of H2O to the solid followed by enough Et2O to incipient cloudiness. Store it overnight at 0o. Add ice-cold Et2O to make 250mL, collect the crystals, wash them with Et2O then pet ether and dry them in air. The purification can be repeated with NaCl and Et2O with ~85% recovery. NB: precipitation will not occur unless enough H2O is present. Its solubility in H2O is 10%. [Cortese J Am Chem Soc 59 2532 1937.] The free acid has m 141-144o. [Norman Ark Kemi 8 331 1956.] It forms mixed micelles and solubilises some membrane proteins [Hajjar et al. J Biol Chem 2 5 8 192 1983]. [Beilstein 10 IV 1611.]
Mode of action
Sodium taurodeoxycholate hydrate functions as a surfactant in experimental applications. It reduces the surface tension of liquids, allowing for improved solubility and dispersion of substances in aqueous solutions. Sodium Taurodeoxycholate Hydrate interacts with lipid molecules, disrupting their organization and facilitating the emulsification of fats. Sodium taurodeoxycholate hydrate also plays a role in cell membrane permeabilization, aiding in the uptake of hydrophobic compounds by cells. At the molecular level, Sodium taurodeoxycholate hydrate interacts with cholesterol and phospholipids, influencing their arrangement and fluidity within lipid bilayers. It can form micelles, which assist in solubilising poorly water-soluble substances for experimental purposes.
Sodium taurodeoxycholate hydrate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD. | +86-18600796368 +86-18600796368 | sales@sjar-tech.com | China | 474 | 58 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3009 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32956 | 60 |
| Shandong chuangyingchemical Co., Ltd. | 18853181302 | sale@chuangyingchem.com | CHINA | 5906 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49374 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29810 | 58 |
| Antai Fine Chemical Technology Co.,Limited | 18503026267 | info@antaichem.com | CHINA | 9636 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32161 | 58 |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | ada@ipurechemical.com | China | 10319 | 58 |
View Lastest Price from Sodium taurodeoxycholate hydrate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-12-25 | Taurodeoxycholic Acid Sodium Salt
207737-97-1
|
US $0.00 / g | 1g | More Than 99% | 100kg/Month | BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD. | |
 |
2024-12-17 | Sodium taurodeoxycholate
207737-97-1
|
US $499.00-399.00 / kg | 0.1kg | 99%min | 1ton | HANGZHOU HAILAN CHEMICAL CO.,LTD. | |
 |
2024-12-13 | Sodium taurodeoxycholate hydrate
207737-97-1
|
US $0.00 / G | 500G | 97%min | 30kg/month | WUHAN FORTUNA CHEMICAL CO., LTD |
-
- Taurodeoxycholic Acid Sodium Salt
207737-97-1
- US $0.00 / g
- More Than 99%
- BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
-
- Sodium taurodeoxycholate
207737-97-1
- US $499.00-399.00 / kg
- 99%min
- HANGZHOU HAILAN CHEMICAL CO.,LTD.
-
- Sodium taurodeoxycholate hydrate
207737-97-1
- US $0.00 / G
- 97%min
- WUHAN FORTUNA CHEMICAL CO., LTD
207737-97-1(Sodium taurodeoxycholate hydrate)Related Search:
1of4