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NSC 15520

NSC 15520 Structure
NSC 15520 structure
CAS No.
730960-98-2
Chemical Name:
NSC 15520
Synonyms
NSC 15520;4,4a,4b,5,6,7,8,8a,9,10-decahydro-4b,8-dimethyl-2-(1-methylethyl)-3H-3,10a-ethanophenanthrene-8,11,12-tricarboxylic acid;3H-3,10a-Ethanophenanthrene-8,11,12-tricarboxylic acid, 4,4a,4b,5,6,7,8,8a,9,10-decahydro-4b,8-dimethyl-2-(1-methylethyl)-
CBNumber:
CB26197342
Molecular Formula:
C24H34O6
Molecular Weight:
418.52
MDL Number:
MOL File:
730960-98-2.mol
Last updated:2024-07-02 08:55:04
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NSC 15520 Properties

Boiling point 617.4±55.0 °C(Predicted)
Density 1.27±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml
form A crystalline solid
pka 4.10±0.70(Predicted)
color White to off-white

NSC 15520 Chemical Properties,Uses,Production

Description

NSC 15520 is an inhibitor of replication protein A 70 (RPA70) dsDNA binding.1 It selectively inhibits dsDNA over ssDNA binding to RPA70 when used at concentrations ranging from 25 to 400 μM. NSC 15520 also inhibits the protein-protein interaction between the cell cycle checkpoint control proteins p53 or Rad9 and RPA70.

References

1. Glanzer, J.G., Liu, S., and Oakley, G.G. Small molecule inhibitor of the RPA70 N-terminal protein interaction domain discovered using in silico and in vitro methods Bioorg. Med. Chem. 19(8),2589-2595(2011).

NSC 15520 Preparation Products And Raw materials

Raw materials

Preparation Products

NSC 15520 Suppliers

Global( 6)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 sales@glpbio.cn China 6870 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11289 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24647 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11975 58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. 025-66113011 18112977050 cb5@aikonchem.com China 10529 58
Supplier Advantage
Shanghai Hongye Biotechnology Co. Ltd 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
TargetMol Chemicals Inc. 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. 58
NSC 15520 3H-3,10a-Ethanophenanthrene-8,11,12-tricarboxylic acid, 4,4a,4b,5,6,7,8,8a,9,10-decahydro-4b,8-dimethyl-2-(1-methylethyl)- 4,4a,4b,5,6,7,8,8a,9,10-decahydro-4b,8-dimethyl-2-(1-methylethyl)-3H-3,10a-ethanophenanthrene-8,11,12-tricarboxylic acid 730960-98-2