TOS-ARG-OME HCL
- CAS No.
- 1784-03-8
- Chemical Name:
- TOS-ARG-OME HCL
- Synonyms
- TAME;L-TAME;TAME,HCl;Tos-Arg-OMe;Tos-Arg-OMe¤HC;Ala-Ala-Ala-OMe;TOS-ARG-OME HCL;H-Tos-Arg-OMe·HCl;Tos-L-Arg-OMe*HCl;TAME HYDROCHLORIDE
- CBNumber:
- CB2669913
- Molecular Formula:
- C14H23ClN4O4S
- Molecular Weight:
- 378.87
- MDL Number:
- MFCD00012578
- MOL File:
- 1784-03-8.mol
- MSDS File:
- SDS
Melting point | 145-147(lit.) |
---|---|
alpha | -14 º (c=4, H2O) |
refractive index | -14 ° (C=4, H2O) |
storage temp. | -20°C |
solubility | methanol: 50 mg/mL, clear, colorless |
form | Fine Crystalline Powder |
color | White |
BRN | 3922357 |
Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months. |
InChIKey | JIQFFACVQXXHMY-YDALLXLXSA-N |
CAS DataBase Reference | 1784-03-8(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07,GHS08,GHS09,GHS02 |
---|---|
Signal word | Danger |
Hazard statements | H319-H361-H371-H336-H304-H411-H224 |
Precautionary statements | P501-P273-P260-P270-P202-P240-P210-P233-P201-P243-P241-P242-P271-P264-P280-P370+P378-P391-P331-P337+P313-P305+P351+P338-P308+P311-P303+P361+P353-P301+P310-P304+P340+P312-P403+P233-P403+P235-P405 |
Hazard Codes | Xi |
Risk Statements | 36/37/38 |
Safety Statements | 22-24/25-37/39-26 |
WGK Germany | 3 |
F | 3-10 |
HS Code | 29252900 |
TOS-ARG-OME HCL price More Price(41)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | T4626 | Nα-p-Tosyl-L-arginine methyl ester hydrochloride | 1784-03-8 | 5g | $61.9 | 2024-03-01 | Buy |
Sigma-Aldrich | 172104 | Anaphase-Promoting Complex Inhibitor, TAME | 1784-03-8 | 50mg | $85.2 | 2024-03-01 | Buy |
TCI Chemical | T0330 | Nα-Tosyl-L-arginine Methyl Ester Hydrochloride >98.0%(T) | 1784-03-8 | 1g | $26 | 2024-03-01 | Buy |
TCI Chemical | T0330 | Nα-Tosyl-L-arginine Methyl Ester Hydrochloride >98.0%(T) | 1784-03-8 | 25g | $207 | 2024-03-01 | Buy |
Cayman Chemical | 17550 | N-4-Tosyl-L-arginine methyl ester (hydrochloride) ≥98% | 1784-03-8 | 5g | $44 | 2024-03-01 | Buy |
TOS-ARG-OME HCL Chemical Properties,Uses,Production
Description
TAME (1784-03-8) binds to the ubiquitin ligase anaphase-promoting complex (APC) preventing its activation by Cdc20 and Cdh1 and resulting in mitotic arrest.1,2
Chemical Properties
white fine crystalline powder
Uses
enzyme inhibitor
Uses
Substrate for trypsin, thrombin, plasmin and other proteases.
Uses
N-4-Tosyl-L-arginine Methyl Ester Hydrochloride acts as a synthetic substrate of serine proteases and thus is used to determine serine proteases from diverse organic sources.
Biochem/physiol Actions
Nα-p-Tosyl-L-arginine methyl ester (TAME) binds to anaphase-promoting complex (APC) and prevents its activation by Cdc20 and Cdh1.
References
1) Zeng et al. (2010) Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage; Cancer Cell, 18 382 2) Zeng and King (2012) An APC/C inhibitor stabilizes Cyclin B1 by prematurely terminating ubiquitination; Nat. Chem. Biol., 8 383
TOS-ARG-OME HCL Preparation Products And Raw materials
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29798 | 60 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 18623 | 58 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32835 | 60 |
GenicBio Limited | +86-21-37621270 | service@genicbio.com | CHINA | 991 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29899 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39916 | 58 |
Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49403 | 58 |
View Lastest Price from TOS-ARG-OME HCL manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-04-17 | Tos-Arg-OMe·HCl
1784-03-8
|
US $1.10 / g | 1g | 99.0% min | 100 tons min | Shaanxi Dideu Medichem Co. Ltd | ||
2019-07-06 | TOS-ARG-OME HCL
1784-03-8
|
US $1.00 / KG | 1KG | 99% | 20kg | Career Henan Chemical Co |
- Tos-Arg-OMe·HCl
1784-03-8
- US $1.10 / g
- 99.0% min
- Shaanxi Dideu Medichem Co. Ltd
- TOS-ARG-OME HCL
1784-03-8
- US $1.00 / KG
- 99%
- Career Henan Chemical Co
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