Enoximone
- CAS No.
- 77671-31-9
- Chemical Name:
- Enoximone
- Synonyms
- Perfan;Pedane;RMI-17043;ENOXIMONE;MDL-17043;Fenoximone;Enoximone USP/EP/BP;4-Methyl-5-(4-(methylthio)benzoyl)-1H-imidazol-2(3H)-one;1,3-DIHYDRO-4-METHYL-5-[4-METHYLTHIOBENZOYL]-2H-IMIDAZOL-2-ONE;4-methyl-5-(4-methylsulfanylbenzoyl)-1,3-dihydroimidazol-2-one
- CBNumber:
- CB2682723
- Molecular Formula:
- C12H12N2O2S
- Molecular Weight:
- 248.3
- MDL Number:
- MFCD00867130
- MOL File:
- 77671-31-9.mol
- MSDS File:
- SDS
| Melting point | 255-258°C |
|---|---|
| Density | 1.33 |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO: 28 mg/mL, soluble |
| pka | 10.37±0.70(Predicted) |
| form | solid |
| color | light yellow |
| CAS DataBase Reference | 77671-31-9(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | C7Z4ITI7L7 |
| ATC code | C01CE03 |
Enoximone price More Price(22)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | E1279 | Enoximone solid | 77671-31-9 | 10mg | $270 | 2024-03-01 | Buy |
| Sigma-Aldrich | E1279 | Enoximone solid | 77671-31-9 | 50mg | $905 | 2022-05-15 | Buy |
| Tocris | 1693 | Enoximone ≥99%(HPLC) | 77671-31-9 | 10 | $169 | 2021-12-16 | Buy |
| Tocris | 1693 | Enoximone ≥99%(HPLC) | 77671-31-9 | 50 | $711 | 2021-12-16 | Buy |
| Usbiological | 255248 | Enoximone | 77671-31-9 | 10mg | $423 | 2021-12-16 | Buy |
Enoximone Chemical Properties,Uses,Production
Description
Enoximone is a phosphodiesterase inhibitor indicated for selective use as a cardiostimulant in heart transplant patient maintenance. It is currently being investigated for other indications including acute congestive heart failure.
Originator
Merrell Dow (USA)
Uses
Enoximone is a phosphodiesterase inhibitor used in the treatment of congestive heart failure and is selective to phosphodiesterase 3. Potent PDE-3 inhibitor.
Definition
ChEBI: Enoximone is an aromatic ketone.
brand name
Perfan IV
Biological Activity
Inhibitor of type III phosphodiesterase (PDE3). Increases intracellular cyclic AMP (cAMP) concentrations and enhances myocardial contractility. Also induces concentration-dependent vasodilation in vitro .
Biochem/physiol Actions
Selective phosphodiesterase III (PDE3) inhibitor. Prevents the degradation of cAMP by PDE. Increased cAMP results in enhanced contractility of the heart.
storage
Store at +4°C
Enoximone Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32957 | 60 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49374 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32165 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 7724 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38632 | 58 | |
| Hu Bei Jiutian Bio-medical Technology CO.,Ltd | 027-88013699 17354350817 | Ryan@jiutian-bio.com | China | 6001 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8467 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57505 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| Mainchem Co., Ltd. | +86-0592-6210733 | sale@mainchem.com | China | 32343 | 55 |
