Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>L-858051

L-858051

L-858051 Structure
L-858051 structure
CAS No.
115116-37-5
Chemical Name:
L-858051
Synonyms
L-858051;L-858,051 (hydrochloride);L858,051 (hydrochloride),L 858,051 (hydrochloride);7-DEACETYL-7BETA-(Y-N-METHYLPIPERAZINO)-BUTYRYLFORSKOLIN 2HCL;FORSKOLIN, 7-DEACETYL-7-[O-(N-METHYLPIPERAZINO)-GAMMA-BUTYRYL]-, DIHYDROCHLORIDE;8,13-EPOXY-7BETA-(N-METHYLPIPERAZINO-GAMMA-BUTYRYLOXY)-1ALPHA,6BETA,9ALPHA-TRIHYDROXY-LABD-14-EN-11-ONE, 2HCL
CBNumber:
CB2703053
Molecular Formula:
C29H50Cl2N2O7
Molecular Weight:
609.62
MDL Number:
MFCD00077349
MOL File:
Mol file
Last updated:2024-10-23 13:36:13
Request For Quotation

L-858051 Properties

storage temp. Store at -20°C
solubility DMF: 20 mg/ml; DMSO: 30 mg/ml; Ethanol: 1 mg/ml; PBS (pH 7.2): 5 mg/ml
form A crystalline solid

L-858051 price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 21206 L-858,051 (hydrochloride) ≥95% 115116-37-5 500μg $36 2023-06-20 Buy
Cayman Chemical 21206 L-858,051 (hydrochloride) ≥95% 115116-37-5 1mg $66 2023-06-20 Buy
Cayman Chemical 21206 L-858,051 (hydrochloride) ≥95% 115116-37-5 5mg $277 2023-06-20 Buy
AK Scientific 1919CV [(3R,4Ar,5S,6S,6aS,10S,10aR,10bS)-3-ethenyl-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-5,6,6a,8,9,10-hexahydro-2H-benzo[f]chromen-5-yl]4-(4-methylpiperazin-1-yl)butanoate;dihydrochloride 115116-37-5 1mg $174 2021-12-16 Buy
Product number Packaging Price Buy
21206 500μg $36 Buy
21206 1mg $66 Buy
21206 5mg $277 Buy
1919CV 1mg $174 Buy

L-858051 Chemical Properties,Uses,Production

Description

L-858,051 is a water-soluble analog of forskolin , a cell-permeant activator of adenylate cyclase.1 L-858,051 activates adenylate cyclase (EC50 = 3 μM), inhibits glucose transport, and blocks cytochalasin B binding in rat adipocyte membranes.2 L-858,051 is used to activate adenylate cyclase and initiate signaling through elevated cAMP synthesis in a variety of cell types in culture.3,4,5

References

1. Laurenza, A., Khandelwal, Y., De Souza, N.J., et al. Stimulation of adenylate cyclase by water-soluble analogues of forskolin Mol. Pharmacol. 32(1),133-139(1987).
2. Joost, H.G., Habberfield, A.D., Simpson, I.A., et al. Activation of adenylate cyclase and inhibition of glucose transport in rat adipocytes by forskolin analogues: structural determinants for distinct sites of action Mol. Pharmacol. 33(4),449-453(1988).
3. Funaki, C., Hodges, R.R., and Dartt, D.A. Role of cAMP inhibition of p44/p42 mitogen-activated protein kinase in potentiation of protein secretion in rat lacrimal gland Am. J. Physiol. Cell Physiol. 293(5),C1551-C1560(2007).
4. Luo, S.-F., Chiu, C.-T., Tsao, H.-L., et al. Effect of forskolin on bradykinin-induced calcium mobilization in cultured canine tracheal smooth muscle cells Cell. Signal. 9(2),159-167(1997).
5. Haj Slimane, Z., Bedioune, I., Lechêne, P., et al. Control of cytoplasmic and nuclear protein kinase A by phosphodiesterases and phosphatases in cardiac myocytes Cardiovasc. Res. 102(1),97-106(2014).

L-858051 Preparation Products And Raw materials

Raw materials

Preparation Products

L-858051 Suppliers

Global( 19)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+8613564774135 zijue.cai@tsbiochem.com United States 19885 58
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 sales@glpbio.cn China 6777 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24647 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
Shanghai Hongye Biotechnology Co. Ltd 58
TargetMol Chemicals Inc. 58

View Lastest Price from L-858051 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
L-858,051 (hydrochloride) pictures 2024-10-24 L-858,051 (hydrochloride)
115116-37-5
 US $1520.00-2500.00 / mg 10g TargetMol Chemicals Inc.

115116-37-5(L-858051)Related Search:

Forskolin
8,13-EPOXY-7BETA-(N-METHYLPIPERAZINO-GAMMA-BUTYRYLOXY)-1ALPHA,6BETA,9ALPHA-TRIHYDROXY-LABD-14-EN-11-ONE, 2HCL 7-DEACETYL-7BETA-(Y-N-METHYLPIPERAZINO)-BUTYRYLFORSKOLIN 2HCL L-858051 FORSKOLIN, 7-DEACETYL-7-[O-(N-METHYLPIPERAZINO)-GAMMA-BUTYRYL]-, DIHYDROCHLORIDE L-858,051 (hydrochloride) L858,051 (hydrochloride),L 858,051 (hydrochloride) 115116-37-5