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ROLIPRAM

ROLIPRAM structure

CAS No.: 61413-54-5

Chemical Name:: ROLIPRAM

Synonyms: 4-(3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL)PYRROLIDIN-2-ONE;ROLIPRAM;SB 95952;ZK-62711;Roliprame;(¨¤)-Rolipr;Rolipram >(±)-Rolipram;ROLIPRAM 98+%;(R,S)-Rolipram

CBNumber:: CB2703866

Molecular Formula:: C16H21NO3

Molecular Weight:: 275.34

MDL Number:: MFCD00270906

MOL File:: 61413-54-5.mol

MSDS File:: SDS

Last updated:2025-01-27 09:38:02

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ROLIPRAM Properties

Melting point	127-133 °C
Boiling point	418.29°C (rough estimate)
Density	1.0677 (rough estimate)
refractive index	1.5500 (estimate)
storage temp.	Sealed in dry,Store in freezer, under -20°C
solubility	H₂O: 0.2 mg/mL
form	solid
pka	16.02±0.40(Predicted)
color	white to off-white
biological source	synthetic (organic)
Water Solubility	H2O: 0.2mg/mL ethanol: 7mg/mL DMSO: 7.3mg/mL
Merck	14,8251
Stability	Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
FDA UNII	K676NL63N7
UNSPSC Code	41106305
NACRES	NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P280a-P304+P340-P305+P351+P338-P405-P501a

Hazard Codes

Risk Statements

36/37/38-11

Safety Statements

26-36

RIDADR

3249

WGK Germany

RTECS

UY5749237

HazardClass

6.1(b)

PackingGroup

III

HS Code

29337900

Toxicity

LD50 oral in mouse: > 300mg/kg

NFPA 704

	0
2		0

ROLIPRAM price More Price(47)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	R6520	Rolipram solid, ≥98% (HPLC)	61413-54-5	10mg	$176	2024-03-01	Buy
Sigma-Aldrich	557330	Rolipram	61413-54-5	5mg	$230	2024-03-01	Buy
TCI Chemical	R0110	Rolipram >98.0%(HPLC)	61413-54-5	50mg	$198	2024-03-01	Buy
TCI Chemical	R0110	Rolipram >98.0%(HPLC)	61413-54-5	250mg	$686	2024-03-01	Buy
Alfa Aesar	J67177	Rolipram, 98%	61413-54-5	5mg	$61.1	2023-06-20	Buy

Product number	Packaging	Price	Buy
R6520	10mg	$176	Buy
557330	5mg	$230	Buy
R0110	50mg	$198	Buy
R0110	250mg	$686	Buy
J67177	5mg	$61.1	Buy

ROLIPRAM Chemical Properties,Uses,Production

Description

Rolipram (61413-54-5) is a selective inhibitor of cAMP-specific phosphodiesterase (PDE4), IC50 = 1 μM. Displays beneficial effects in neurodegenerative diseases. Rolipram also displays anti-inflammatory activity and synergizes with forskolin (cat.# 10-2073). Cell permeable.

Chemical Properties

Yellowish solid

Uses

(±)-Rolipram is a cAMP-specific phosphodiesterase 4 (PDE4) inhibitor.

Uses

Pharmacological tool for characterization of phosphodiesterase isoenzymes.

Uses

A selective, cell permeable inhibitor of cAMP-specific phosphodiesterase (PDE4).

Uses

antipsychotic

Definition

ChEBI: Rolipram is a member of the lclass of pyrrolidin-2-ones that is pyrrolidin-2-one bearing a 3-(cyclopentyloxy)-4-methoxyphenyl substituent at the 4-position. It is a type IV-specific phosphodiesterase (PDE4) inhibitor. It has a role as an antidepressant and an EC 3.1.4.* (phosphoric diester hydrolase) inhibitor.

General Description

A cell-permeable, selective inhibitor of cAMP-specific phosphodiesterase (PDE IV; IC₅₀ = 800 nM). A rolipram-insensitive PDE IV subtype is also known to exist. Also inhibits NF-κB and NFAT activation in Jurkat and primary T cells.

Biological Activity

Selective inhibitor of cAMP phosphodiesterase (PDE4) (IC 50 = 2.0 μ M). Discriminates between two conformational states of PDE4 isoenzymes. See separate isomers ((R)-(-)-Rolipram and (S)-(+)-Rolipram).

Biochem/physiol Actions

Cell permeable: yes

storage

Room temperature

References

1) Reeves et al. (1987), The identification of a new cyclic nucleotide phosphodiesterase activity in human and guinea-pig cardiac ventricle. Implications for the mechanism of action of selective phosphodiesterase; Biochem. J., 241 535 2) Nishi et al. (2008), Distinct Roles of PDE4 and PDE10A in the Regulation of cAMP/PKA Signaling in the Striatum; J. Neurosci., 28 10460 3) Christiansen et al. (2011), Combined anti-inflammatory effects of β2-adrenergic agonists and PDE4 inhibitors on astrocytes by upregulation of intracellular cAMP; Neurochem. Int., 59 837

ROLIPRAM synthesis

Synthesis of ROLIPRAM from Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-

ROLIPRAM Preparation Products And Raw materials

Raw materials

Preparation Products

ROLIPRAM Suppliers

Global( 202)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29730	60
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49732	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29808	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32159	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	sales@tnjchem.com	China	34563	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	22793	58
AFINE CHEMICALS LIMITED	+86-0571-85134551	sales@afinechem.com	China	15350	58
Hefei Hirisun Pharmatech Co., Ltd	+8615056975894	shawn@hirisunpharm.com	CHINA	9911	58
Guangzhou TongYi biochemistry technology Co.,LTD	+8613073028829	mack@tongyon.com	China	2994	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
TargetMol Chemicals Inc.	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Dideu Industries Group Limited	58
AFINE CHEMICALS LIMITED	58
Hefei Hirisun Pharmatech Co., Ltd	58
Guangzhou TongYi biochemistry technology Co.,LTD	58
InvivoChem	58

View Lastest Price from ROLIPRAM manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-11-19	Rolipram 61413-54-5	US $43.00-87.00 / mg		99.26%	10g	TargetMol Chemicals Inc.
2021-07-02	rolipram 61413-54-5	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd
2020-02-17	ROLIPRAM 61413-54-5	US $1.00 / KG	1KG	99%	200kgs	Career Henan Chemical Co

Rolipram
61413-54-5
US $43.00-87.00 / mg
99.26%
TargetMol Chemicals Inc.

rolipram
61413-54-5
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

ROLIPRAM
61413-54-5
US $1.00 / KG
99%
Career Henan Chemical Co

ROLIPRAM Spectrum

ROLIPRAM(61413-54-5)¹HNMR

61413-54-5(ROLIPRAM)Related Search:

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S- (+)-Rolipram (R)-(-)-ROLIPRAM,(S)-(+)-ROLIPRAM,Rolipram (R)-(-)- ROLIPRAM [6-3H] [METHYL-3H]ROLIPRAM S-Desmethyl-Rolipram

(+)-Desmethyl-Rolipram,R-Desmethyl-Rolipram (R,S)-Desmethyl-Rolipram (R)-(-)-ROLIPRAM, >98%

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ROLIPRAM 98+% Roliprame 2-Pyrrolidinone, 4-[3-(cyclopentyloxy)-4-methoxyphenyl]- SB 95952 4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone, ZK62711 4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]-2-PYRROLIDINONE (R,S)-Rolipram ZK-62711, SB95952, ME-3167 Rolipram, >=97% ROLIPRAM PYRROLIDIN-2-ONE, 4-(3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL)- (+/-) ZK-62711 4-(3-(cyclopentyloxy)-4-methoxyphenyl)-2-pyrrolidinon SB95952;ZK62711;(R;S)-ROLIPRAM;SB 95952;ZK 62711;SB-95952;ZK-62711 Rolipram - CAS 61413-54-5 - Calbiochem Rolipram, 98%, a PDE4 inhibitor Rolipram > Rolipram Rolipram ROLIPRAM USP/EP/BP Rolipram - CAS 61413-54-5 Rolipram (ME 3167 RolipramQ: What is Rolipram Q: What is the CAS Number of Rolipram Q: What is the storage condition of Rolipram Q: What are the applications of Rolipram 4-(3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL)PYRROLIDIN-2-ONE Rolipram (ZK-62711) (¨¤)-Rolipr (R,S)-Rolipram, Selective PDE4 inhibitor Rolipram, 10 mM in DMSO (±)-Rolipram 61413-54-5 C16H21NO3 BioChemical Cell Biology Cell Signaling and Neuroscience Cyclic Nucleotide Metabolism G Proteins and Cyclic Nucleotides Phosphodiesterase Inhibitors Inhibitor DIPIPERON Inhibitors Antineoplastic Cyclic Nucleotide related Signalling