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Tetraethyleneglycol monododecyl ether

CAS No.
5274-68-0
Chemical Name:
Tetraethyleneglycol monododecyl ether
Synonyms
TETRAETHYLENE GLYCOL MONODODECYL ETHER;3,6,9,12-Tetraoxatetracosan-1-ol;BRIJ 30;C12E4;Polyoxyl 4 lauryl ether;POLYOXYETHYLENE 4 LAURYL ETHER;3,6,9,12-Tetraoxa-1-tetracosanol;BRIJ(R) 30;BRIJ(TM) 30;n-dodecyl-PEG4-OH
CBNumber:
CB2706807
Molecular Formula:
C20H42O5
Molecular Weight:
362.54
MDL Number:
MFCD00043063
MOL File:
5274-68-0.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-06-24 18:39:39

Tetraethyleneglycol monododecyl ether Properties

Melting point 14°C
Boiling point 185°C/0.2mmHg(lit.)
Density 0.946 g/mL at 20 °C(lit.)
refractive index n20/D 1.453
Flash point >230 °F
storage temp. 2-8°C
pka 14.36±0.10(Predicted)
form Liquid
color Colorless to light yellow
Odor at 100.00%. mild alcoholic
BRN 1791369
Stability Stable. Incompatible with strong oxidizing agents.
Cosmetics Ingredients Functions ANTISTATIC
SURFACTANT - EMULSIFYING
SURFACTANT - CLEANSING
FRAGRANCE
InChI 1S/C20H42O5/c1-2-3-4-5-6-7-8-9-10-11-13-22-15-17-24-19-20-25-18-16-23-14-12-21/h21H,2-20H2,1H3
InChIKey WPMWEFXCIYCJSA-UHFFFAOYSA-N
SMILES CCCCCCCCCCCCOCCOCCOCCOCCO
LogP 4.204 (est)
CAS DataBase Reference 5274-68-0(CAS DataBase Reference)
Indirect Additives used in Food Contact Substances POLYOXYETHYLENE (4) LAURYL ETHER
FDA 21 CFR 178.3520
EWG's Food Scores 1-3
FDA UNII 6HQ855798J
EPA Substance Registry System Tetraethylene glycol monododecyl ether (5274-68-0)
Cosmetics Info Laureth-4
UNSPSC Code 41116107
NACRES NA.25

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)Environment (GHS09)
GHS07,GHS09
Signal word  Warning
Hazard statements  H315-H319-H335-H410
Precautionary statements  P305+P351+P338
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xi,N
Risk Statements  36/37/38-50/53-52/53
Safety Statements  26-36-61-60
RIDADR  UN 3082 9/PG 3
WGK Germany  2
RTECS  MD0875000
F  3
TSCA  TSCA listed
HS Code  34029000
Storage Class 10 - Combustible liquids
Hazard Classifications Aquatic Acute 1
Aquatic Chronic 1
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

Tetraethyleneglycol monododecyl ether price More Price(24)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 86694 Tetraethylene glycol monododecyl ether non-ionic 5274-68-0 1ml $189 2026-04-30 Buy
Sigma-Aldrich 1372424 Polyoxyl 4 lauryl ether United States Pharmacopeia (USP) Reference Standard 5274-68-0 1ml $192 2026-04-30 Buy
TCI Chemical T0769 Tetraethylene Glycol Monododecyl Ether >98.0%(GC) 5274-68-0 5mL $359 2021-12-16 Buy
ChemScene CS-0152178 PEG 4 lauryl ether ≥95% 5274-68-0 1g $43 2026-06-04 Buy
ChemScene CS-0152178 PEG 4 lauryl ether ≥95% 5274-68-0 5g $96 2026-06-04 Buy
Product number Packaging Price Buy
86694 1ml $189 Buy
1372424 1ml $192 Buy
T0769 5mL $359 Buy
CS-0152178 1g $43 Buy
CS-0152178 5g $96 Buy

Tetraethyleneglycol monododecyl ether Chemical Properties, Uses, Production

Synthesis

Synthetic route of Tetraethyleneglycol monododecyl ether

General synthetic method: Under argon protection, iodoalkane (1 eq.) was added to a DMF (40 mL) solution containing triethylene glycol or tritetraethylene glycol (1 eq.). The mixture was cooled to 0 °C, and sodium hydride (1.5 eq. 60% in mineral oil) was added. The mixture was stirred for 2 h, quenched with water, and extracted with ethyl acetate (20 mL × 2). The ethyl acetate phases were combined, washed with saturated brine, dried over anhydrous sodium sulfate, and concentrated to obtain the crude product. The crude product was purified by silica gel column chromatography (ethyl acetate-n-hexane). The sample was immediately used for the next reaction.

The synthesis of lauryl ether-4 was carried out using the general synthetic method described above. Tetraethylene glycol (2 mL, 11.59 mmol) was reacted with 1-iodododecane (4.42 g, 11.59 mmol) and sodium hydride (0.70 g, 17.38 mmol) to give lauryl ether-4 (2.18 g, 6.02 mmol, yield 52%), a colorless oil; Rf = 0.41 (ethyl acetate-n-hexane 3:2).

Chemical Properties

white solid or colourless liquid

Uses

Tetraethylene Glycol Monododecyl Ether is a well-characterized and non-ionic surfactant.

Definition

ChEBI: Tetraethylene glycol monododecyl ether is a poly(ethylene glycol).

112-60-7
143-15-7
5274-68-0
Synthesis of Tetraethyleneglycol monododecyl ether from tetraethylene glycol and 1-Bromododecane

Tetraethyleneglycol monododecyl ether Preparation Products And Raw materials

Global Suppliers ( 177)
Supplier Tel Email Country ProdList Advantage
Beijing Minruida Technology Co., Ltd. 010-82387566 sales@mreda.com.cn China 19323 58
Tianjin Exceedbio Technology Co., Ltd. 022-87899679 13034388368 exceedbio@yeah.net China 41 55
Suzhou Greet Medical Technology Co., Ltd. 0512-62384765 13701544574 renwei@great-chem.cn China 79 58
Hubei Zhonglong Kangsheng fine chemical Co.,Ltd 027-83850125 15927542930 3321236220@qq.com China 955 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Adamas Reagent, Ltd. 400-6009262 15618770481 yhx@titansci.com China 14098 59
Nanjing Chemlin Chemical Co., Ltd 025-83697070 13770331960 info@chemlin.com.cn China 16307 64

View Latest Price from Tetraethyleneglycol monododecyl ether manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Tetraethyleneglycol monododecyl ether  pictures 2026-08-20 Tetraethyleneglycol monododecyl ether
5274-68-0
$1.10 1g 99.00% 100 Tons Min Dideu Industries Group Limited
Tetraethyleneglycol monododecyl ether pictures 2026-03-20 Tetraethyleneglycol monododecyl ether
5274-68-0
$10.00 1kg 99% 100 mt Hebei Chuanghai Biotechnology Co., Ltd
Tetraethyleneglycol monododecyl ether pictures 2025-05-23 Tetraethyleneglycol monododecyl ether
5274-68-0
$45.00 1kg 99% 20 tons Hebei Zhuanglai Chemical Trading Co Ltd
TETRAETHYLENE GLYCOL DODECYL ETHER TETRAETHYLENE GLYCOL MONO-N-DODECYL ETHER POLYETHYLENE GLYCOL DODECYL ETHER BRIJ(TM) 30 BRIJ(R) 30 DODECYL TETRAETHYLENE GLYCOL ETHER DODECYLTETRAGLYCOL 2-(2-(2-(2-dodecyloxy-ethoxy)-ethoxy)-ethoxy)-ethanol Tetraethyleneglycol monododecyl ether 1mM Solution TEGmono-n-dodecylether Tetraethylenen glycol mono-n-dodecyl ether dodecyltetraethylene glycol monoether Tetraethyleneglycol monolauryl ether Detergent Screening Solution 14/Fluka kit no 66317, Tetraethyleneglycol monododecyl ether solution C12E4, Dodecyl tetraethylene glycol ether, Dodecyltetraglycol (3,6,9,12-Tetraoxadodecane-1-yl)dodecyl ether 11-(Dodecyloxy)-3,6,9-trioxa-undecane-1-ol 2-[2-[2-(2-lauryloxyethoxy)ethoxy]ethoxy]ethanol Polyoxyl 4 Lauryl Ether (1 mL) 3,Tetraethyleneglycol Monododecyl ether Polyoxyethylene dodecyl alcohol ether Detergent Screening Solution 14/Fluka kit no 66317 Tetraethyleneglycol monododecyl ether solution 2-〔2-[2-(2-Dodecyloxyethoxy)ethoxy]ethoxy〕Ethano Tetraethylene Glycol Monododecyl Ether > Tetraethylene Glycol Monododecyl Ether,96% Tetraethyleneglycol monododecyl ether ISO 9001:2015 REACH POLYOXYETHYLENE 4 LAURYL ETHER BRIJ 30 3,6,9,12-Tetraoxa-1-tetracosanol Polyoxyl 4 lauryl ether 1-O-(n-Dodecyl)-tetraethyleneglycol (C12E4) 3,6,9,12-Tetraoxatetracosan-1-ol (6CI, 7CI, 8CI, 9CI, ACI) PEG 4 lauryl ether Polidocanol Impurity 3 (Polidocanol E4) Dodecyloxy-PEG4-OH tetrapolyethyldiolether 3,6,9,12-Tetraoxatetracosan-1-ol C12E4 TETRAETHYLENE GLYCOL MONODODECYL ETHER n-dodecyl-PEG4-OH 5274-68-0 5274-60-8 CH3CH211OCH2CH24OH BioChemical Detergents Non-Ionic Ether Type (Surfactants) Ethylene Glycols & Monofunctional Ethylene Glycols Functional Materials Monofunctional Ethylene Glycols Nonionic Surfactants Surfactants Glycon Biochem