2-Bromo-4'-methoxyacetophenone
- CAS No.
- 2632-13-5
- Chemical Name:
- 2-Bromo-4'-methoxyacetophenone
- Synonyms
- 2-BROMO-1-(4-METHOXYPHENYL)ETHAN-1-ONE;2-BROMO-1-(4-METHOXYPHENYL)ETHANONE;PTP Inhibitor II;4-methoxy phenecyl bromide;PTP inhibitor 1;AKOS BBS-00000817;2-Bromo-4-methoxy;TIMTEC-BB SBB007777;2-Bromo-4'-methoxyac;4-METHOXYPHENACYL BR
- CBNumber:
- CB2715762
- Molecular Formula:
- C9H9BrO2
- Molecular Weight:
- 229.07
- MDL Number:
- MFCD00000201
- MOL File:
- 2632-13-5.mol
- MSDS File:
- SDS
Melting point | 69-71 °C(lit.) |
---|---|
Boiling point | 215.8°C (rough estimate) |
Density | 1.4921 (rough estimate) |
refractive index | 1.5500 (estimate) |
storage temp. | 2-8°C |
solubility | Chloroform (Slightly), Methanol (Slightly) |
form | Crystals or Crystalline Powder |
color | Off-white to light brown |
Water Solubility | It is soluble in DMSO, water (partly miscible), most organic solvents, and methanol. |
BRN | 743112 |
InChI | InChI=1S/C9H9BrO2/c1-12-8-4-2-7(3-5-8)9(11)6-10/h2-5H,6H2,1H3 |
InChIKey | XQJAHBHCLXUGEP-UHFFFAOYSA-N |
SMILES | C(=O)(C1=CC=C(OC)C=C1)CBr |
CAS DataBase Reference | 2632-13-5(CAS DataBase Reference) |
FDA UNII | PV5M69J53H |
NIST Chemistry Reference | Ethanone, 2-bromo-1-(4-methoxyphenyl)-(2632-13-5) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS05,GHS07 |
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Signal word | Danger | |||||||||
Hazard statements | H314-H335 | |||||||||
Precautionary statements | P260-P271-P280-P301+P330+P331-P303+P361+P353-P305+P351+P338 | |||||||||
Hazard Codes | C,Xi | |||||||||
Risk Statements | 34-36/37-36/37/38 | |||||||||
Safety Statements | 26-27-28-36/37/39-45-37/39 | |||||||||
RIDADR | UN 3261 8/PG 2 | |||||||||
WGK Germany | 3 | |||||||||
F | 8-9-19-21 | |||||||||
Hazard Note | Corrosive | |||||||||
HazardClass | 8 | |||||||||
PackingGroup | III | |||||||||
HS Code | 29147090 | |||||||||
NFPA 704 |
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2-Bromo-4'-methoxyacetophenone price More Price(46)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 115665 | 2-Bromo-4′-methoxyacetophenone 97% | 2632-13-5 | 5g | $83.8 | 2024-03-01 | Buy |
Sigma-Aldrich | 115665 | 2-Bromo-4′-methoxyacetophenone 97% | 2632-13-5 | 25g | $399 | 2024-03-01 | Buy |
TCI Chemical | M1004 | 4'-Methoxyphenacyl Bromide >98.0%(GC) | 2632-13-5 | 5g | $30 | 2024-03-01 | Buy |
TCI Chemical | M1004 | 4'-Methoxyphenacyl Bromide >98.0%(GC) | 2632-13-5 | 25g | $85 | 2024-03-01 | Buy |
Alfa Aesar | A13415 | 2-Bromo-4'-methoxyacetophenone, 98% | 2632-13-5 | 5g | $33.65 | 2024-03-01 | Buy |
2-Bromo-4'-methoxyacetophenone Chemical Properties,Uses,Production
Chemical Properties
off-white to light brown crystals or
Uses
2-Bromo-4'-methoxyacetophenone, is used as a cell-permeable, covalent and potent protein tyrosine phosphatase inhibitor.
Uses
2-Bromo-4'-methoxyacetophenone is a α-haloacetophenone derivatives tested for inhibition of protein tyrosine phosphatases SHP-1 and PTP1B.
Preparation
Obtained by reaction of N-bromosuccinimide (NBS) with 4-methoxyacetophenone in the presence of trimethylsilyl trifluoromethanesulfonate (TMS-OTf) in acetonitrile at r.t. for 24 h (87%).
Biological Activity
ki: 128 μmptp inhibitor ii is a protein tyrosine phosphatase (ptp) inhibitor.protein tyrosine phosphatases (ptps) are reported to be involved in the etiology of diabetes mellitus, neural diseases such as alzheimer and parkinson diseases, regulation of allergy and inflammation, or ptps are even regarded to be responsible for the pathogens.
in vitro
in a previous study, it was found that all of the previously reported ptp inhibitors contained a negatively charged, nonhydrolyzable py mimetic as the core structure, such as malonates, aryl carboxylates, phosphonates, or cinnamates. the poor membrane permeability of these inhibitors might compromise their potential development. it was reported that several α-bromoacetophenone derivatives, such as ptp inhibitor ii, could act as fairly potent ptp inhibitors, by covalently alkylating the conserved catalytic cysteine in the ptp active site. since ptp inhibitor ii is neutral, it could readily diffuse into human b cells and inhibit the intracellular ptps. the sar study was performed with the catalytic domain of phosphatase shp-1, and ti was found that ptp inhibitor ii showed time-dependent inactivation of shp-1, consistent with the mechanism. furthermore, the potency of ptp inhibitor ii was described by an equilibrium constant ki, representing the dissociation constant of the noncovalent enzyme–inhibitor complex. ptp inhibitor ii bound with lower affinity than ptp inhibitor i with ki values of 128 μm [1].
References
[1] p. heneberg. use of protein tyrosine phosphatase inhibitors as promising targeted therapeutic drugs. current medicinal chemistry 16(6), 706-733 (2009).
2-Bromo-4'-methoxyacetophenone Preparation Products And Raw materials
Raw materials
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Preparation Products
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Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12495 | 58 |
Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 5873 | 58 |
Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5895 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29798 | 60 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 18628 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21663 | 55 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9284 | 55 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29888 | 58 |
Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 19563 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39916 | 58 |
View Lastest Price from 2-Bromo-4'-methoxyacetophenone manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-09-29 | 2-Bromo-4'-methoxyacetophenone
2632-13-5
|
US $30.00-10.00 / kg | 10kg | 99% | 100000kg | Hebei Chuanghai Biotechnology Co,.LTD | ||
2024-08-15 | 2-Bromopropionyl bromide
2632-13-5
|
US $40.00-10.00 / kg | 1kg | 0.99 | 15 tons | Hebei Yanxi Chemical Co., Ltd. | ||
2023-09-26 | 2-Bromopropionyl bromide
2632-13-5
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mojin Biotechnology Co., Ltd |
- 2-Bromo-4'-methoxyacetophenone
2632-13-5
- US $30.00-10.00 / kg
- 99%
- Hebei Chuanghai Biotechnology Co,.LTD
- 2-Bromopropionyl bromide
2632-13-5
- US $40.00-10.00 / kg
- 0.99
- Hebei Yanxi Chemical Co., Ltd.
- 2-Bromopropionyl bromide
2632-13-5
- US $0.00 / KG
- 99%
- Hebei Mojin Biotechnology Co., Ltd