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Lomefloxacin

CAS No.
98079-51-7
Chemical Name:
Lomefloxacin
Synonyms
Lomefloxacine;LFLX;dm-10;Clfimono;SC 47111A;Lomel9act;LOMEFLOXACIN;LEMOFLOXACIN;LoMenfloxacin;Loniefloxacin
CBNumber:
CB2723615
Molecular Formula:
C17H19F2N3O3
Molecular Weight:
351.35
MDL Number:
MFCD00242673
MOL File:
98079-51-7.mol
Last updated:2024-12-18 14:08:52

Lomefloxacin Properties

Melting point 239-240 C
Boiling point 542.7±50.0 °C(Predicted)
Density 1.342±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility DMSO (Slightly), Methanol (Slightly, Heated, Sonicated)
form Solid
pka -0.25±0.20(Predicted)
color Pale Yellow to Light Yellow
CAS DataBase Reference 98079-51-7(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII L6BR2WJD8V
ATC code J01MA07,S01AE04
EPA Substance Registry System 3-Quinolinecarboxylic acid, 1-ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo- (98079-51-7)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H312-H332
Precautionary statements  P280
Hazard Codes  Xn,Xi
Risk Statements  22-36/37/38
Safety Statements  26-36
WGK Germany  3
RTECS  VB1997500
HS Code  29419000
Toxicity LD50 in mice (mg/kg): 245.6 i.v.; >4000 orally (Itoh)

Lomefloxacin price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC L469418 Lomefloxacin 98079-51-7 100mg $70 2021-12-16 Buy
AK Scientific J98130 Lomefloxacin 98079-51-7 1g $78 2021-12-16 Buy
AK Scientific J98130 Lomefloxacin 98079-51-7 5g $239 2021-12-16 Buy
AvaChem 3890 Lomefloxacin 98079-51-7 100mg $179 2021-12-16 Buy
Crysdot CD31000032 Lomefloxacin 98+% 98079-51-7 100mg $55 2021-12-16 Buy
Product number Packaging Price Buy
L469418 100mg $70 Buy
J98130 1g $78 Buy
J98130 5g $239 Buy
3890 100mg $179 Buy
CD31000032 100mg $55 Buy

Lomefloxacin Chemical Properties,Uses,Production

Description

Lomefloxacin is a kind of fluoroquinolone antibiotics used for the treatment of bacterial infections such as bronchitis and urinary tract infection. It can also used to prevent the urinary tract infections prior surgery. It has bactericidal effect against a wide range of gram-negative and gram-positive organisms. It takes effect through interfering with the normal function of the bacteria enzyme DNA gyrase and topoisomerase IV, further inhibiting the transcription and replication of bacterial DNA. This effect results in strand breakage of bacterial chromosome, supercoiling and resealing, further causing bacteria death.

References

https://en.wikipedia.org/wiki/Lomefloxacin
https://www.drugbank.ca/drugs/DB00978

Description

Lomefloxacin is a once-daily, third-generation quinolone antibiotic useful in the treatment of bacterial infections. The new fluorinated quinolone does not interfere with the metabolism of theophylline; it is efficacious against pathogens resistant to cephalosporins, penicillins and aminoglycosides.

Chemical Properties

colorless Needles

Originator

Hokuriku Seiyaku (Japan)

Uses

Anti bacterial.

Definition

ChEBI: A fluoroquinolone antibiotic, used (generally as the hydrochloride salt) to treat bacterial infections including bronchitis and urinary tract infections. It is also used to prevent urinary tract infections prior to surgery.

Manufacturing Process

A mixture of 1.00 g of 1-ethyl-6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3- carboxylic acid, 1.10 g of 2-methylpiperazine and 10 ml of pyridine was heated for 15 minutes under reflux. The reaction mixture was evaporated and methanol was added to the residue. The precipitate was filtered and recrystallized from ethanol to give 0.36 g of the 1-ethyl-6,8-difluoro-1,4- dihydro-7-(3-methyl-1-piperazinyl)-4-oxoquinoline-3-carboxylic acid as colorless needles, melting point 239.0-240.5°C.
By the usual manner the hydrochloride was prepared and recrystallized from water as colorless needles, melting point 290-300°C (decomp.).

brand name

Uniquin

Therapeutic Function

Antibacterial

Pharmaceutical Applications

A difluoropiperazinyl quinolone formulated as the hydrochloride salt for oral administration. The in-vitro activity is very similar to that of norfloxacin . It is active against Enterobacteriaceae and fastidious Gram-negative bacilli, including L. pneumophila. Activity against Campylobacter spp., Ps. aeruginosa, Acinetobacter and Chlamydia spp. is poor. It has reduced activity against staphylococci and poor activity against streptococci, L. monocytogenes, anaerobes and Mycobacterium spp.
A 400 mg oral dose achieves a concentration of 3–5 mg/L after 1–1.5 h. In escalating oral doses of 100, 400 and 800 mg to volunteers, the AUC was essentially proportional to the dosage, the mean plasma concentrations following 100, 400 and 800 mg doses being approximately 1.1, 4.7 and 7.5 mg/L, respectively.
Several metabolites have been described, accounting for <5% of the oral dose. Elimination occurs principally via the kidneys and 50–70% of a dose appears in the urine over 24 h. In patients with impaired renal function given 400 mg orally, the apparent elimination half-life ranged from 8 to 44 h, depending on the degree of renal failure. Non-renal clearance was also impaired, but there was no significant change in other pharmacokinetic parameters. The daily dosage (400 mg) should be reduced to 280 mg when the creatinine clearance falls below 30 mL/min. Hemodialysis has no effect on the plasma concentration. The effect of lomefloxacin on the plasma concentration of theophylline is clinically insignificant and no dosage adjustment is required.
The main adverse event is phototoxicity; other adverse events (mainly diarrhea, abdominal pain, skin reactions, dizziness, headache and insomnia) occur in about 10% of patients.
It is chiefly used in urinary tract infection, but is no longer widely available.

Clinical Use

1-Ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid (Maxaquin) is adifluorinated quinolone with a longer elimination half-life(7–8 hours) than other members of its class. It is the onlyquinolone for which once-daily oral dosing suffices. The oralbioavailability of lomefloxacin is estimated to be 95% to98%. Food slows, but does not prevent, its oral absorption.The extent of biotransformation of lomefloxacin is only about5%, and high concentrations of unchanged drug, rangingfrom 60% to 80%, are excreted in the urine. The comparativelylong half-life of lomefloxacin is apparently because ofits excellent tissue distribution and renal reabsorption and not because of plasma protein binding (only ~10%) or enterohepaticrecycling (biliary excretion is estimated to be ~10%).
Lomefloxacin has been approved for two primary indications. First, it is indicated for acute bacterial exacerbations of chronic bronchitis caused by H. influenzae or Moraxella (Branhamella) catarrhalis, but not if Streptococcus pneumoniae is the causative organism. Second, it is used for prophylaxis of infection following transurethral surgery. Lomefloxacin also finds application in the treatment of acute cystitis and chronic urinary tract infections caused by Gram-negative bacilli.

Global( 196)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Kangcang new material Technology Co., LTD
+8615713292910 Nancy@kangcang.com.cn China 341 58
Capot Chemical Co.,Ltd.
+86-(0)57185586718 +86-13336195806 sales@capot.com China 29791 60
career henan chemical co
+86-0371-86658258 +8613203830695 sales@coreychem.com China 29880 58
Hubei Jusheng Technology Co.,Ltd.
18871490254 linda@hubeijusheng.com CHINA 28172 58
Shanghai Longyu Biotechnology Co., Ltd.
+8619521488211 info@longyupharma.com China 2542 58
Chongqing Chemdad Co., Ltd
+86-023-6139-8061 +86-86-13650506873 sales@chemdad.com China 39894 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427 sales@conier.com China 49374 58
Hebei Mojin Biotechnology Co., Ltd
+86 13288715578 +8613288715578 sales@hbmojin.com China 12834 58
SIMAGCHEM CORP
+86-13806087780 sale@simagchem.com China 17365 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32161 58

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View Lastest Price from Lomefloxacin manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Lomefloxacin pictures 2024-11-19 Lomefloxacin
98079-51-7
US $68.00-54.00 / mg 99.26% 10g TargetMol Chemicals Inc.
Lomefloxacin pictures 2024-11-19 Lomefloxacin
98079-51-7
US $68.00-54.00 / mg 99.26% 10g TargetMol Chemicals Inc.
Lomefloxacin pictures 2024-11-14 Lomefloxacin
98079-51-7
US $125.00 / KG 1KG 99% 100kg Baoji Guokang Bio-Technology Co., Ltd.
  • Lomefloxacin pictures
  • Lomefloxacin
    98079-51-7
  • US $68.00-54.00 / mg
  • 99.26%
  • TargetMol Chemicals Inc.
  • Lomefloxacin pictures
  • Lomefloxacin
    98079-51-7
  • US $68.00-54.00 / mg
  • 99.26%
  • TargetMol Chemicals Inc.
  • Lomefloxacin pictures
  • Lomefloxacin
    98079-51-7
  • US $125.00 / KG
  • 99%
  • Baoji Guokang Bio-Technology Co., Ltd.
LEMOFLOXACIN LOMEFLOXACIN LOMEFLOXACIN BASE 1-ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid 1,4-dihydro-6,8-difluoro-1-ethyl-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolin 1-Ethyl-6,8-difluoro-7-(3-methylpiperazino)-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid LFLX LoMenfloxacin 3-quinolinecarboxylicacid,1,4-dihydro-6,8-difluoro-1-ethyl-7-(3-methyl-1-pipe dm-10 1-Ethyl-6,8-Difluoro-1,4-Dihydror-7-(3-Methyl-1-Piperazinyl)-4-Oxo-3-QuinolinecarboxylicacidHydrochloride LOMEFLOXACINHYDROCHLORIDE(SUBJECTTOPATENTFREE) 1-Ethyl-6,8-difluoro-7-(3-methyl-1-piperazinyl)-4-oxo-1,4-dihydro-3-quinoline carboxylic acid 3-Quinolinecarboxylic acid, 1-ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo- (9CI) DM 10 (bactericide) SC 47111A Lomefloxacin (base and/or unspecified salts) Loniefloxacin 1-Ethyl 1-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperaziny1)-4-oxo-3-quinolinecarboxylic acid 1,4-Dihydro-6,8-difluoro-1-ethyl-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid 3-Quinolinecarboxylic acid, 1,4-dihydro-6,8-difluoro-1-ethyl-7-(3-methyl-1-piperazinyl)-4-oxo- Clfimono Lomel9act 1-Ethyl-4-oxo-6,8-difluoro-7-(3-methyl-1-piperazinyl)-1,4-dihydroquinoline-3-carboxylic acid 1-Ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxoquinoline-3-carboxylic acid Lomefloxacino Lomefloxacinum 1-ethyl-6,8-difluoro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid hydrochloride Lomefloxacin Solution in Methanol Lomefloxacin(Hydrochloric acid salt state) 3-Quinolinecarboxylic acid, 1-ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo- Lomefloxacin USP/EP/BP LomefloxacinQ: What is Lomefloxacin Q: What is the CAS Number of Lomefloxacin Q: What is the storage condition of Lomefloxacin Q: What are the applications of Lomefloxacin Lomefloxacine Lomefloxacin-hydrochloride-D5 1-Ethyl-6,8-difluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 98079-51-7 C17H19F2N3O3 C17H19F21N5O3 C17H19F2N3O3xHCl Antibiotics A to Z Antibiotics Antibiotics G-M BioChemical Peptide Synthesis/Antibiotics Antibiotic Explorer Active Pharmaceutical Ingredients