1-Methylindazole-3-carboxylic acid
- CAS No.
- 50890-83-0
- Chemical Name:
- 1-Methylindazole-3-carboxylic acid
- Synonyms
- 1-METHYL-1H-INDAZOLE-3-CARBOXYLIC ACID;Granisetron Related CoMpound D;AKOS BB-9979;3-Dicyclohexylurea;TIMTEC-BB SBB000193;N'-Dicyclohexylurea;N-methylindazolic acid;Granisetron Impurity D;1-Methyl-indazole-3-acid;Granisetron EP impurity D
- CBNumber:
- CB2730011
- Molecular Formula:
- C9H8N2O2
- Molecular Weight:
- 176.17
- MDL Number:
- MFCD00272569
- MOL File:
- 50890-83-0.mol
| Melting point | 213 °C |
|---|---|
| Boiling point | 383.7±15.0 °C(Predicted) |
| Density | 1.35±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| pka | 3.14±0.10(Predicted) |
| form | Solid |
| color | White to Off White |
| Water Solubility | Insoluble in water. Soluble in DMSO and Methanol. |
| InChI | InChI=1S/C9H8N2O2/c1-11-7-5-3-2-4-6(7)8(10-11)9(12)13/h2-5H,1H3,(H,12,13) |
| InChIKey | OVVDFORZEGKEJM-UHFFFAOYSA-N |
| SMILES | N1(C)C2=C(C=CC=C2)C(C(O)=O)=N1 |
| CAS DataBase Reference | 50890-83-0(CAS DataBase Reference) |
| FDA UNII | F9P5J2E2BU |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H319 | |||||||||
| Precautionary statements | P301+P312+P330-P305+P351+P338 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-36-36/37/38 | |||||||||
| Safety Statements | 26-36/37/39-22 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Harmful | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29339900 | |||||||||
| NFPA 704 |
|
1-Methylindazole-3-carboxylic acid price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PHR2871 | Granisetron Related Compound D pharmaceutical secondary standard, certified reference material | 50890-83-0 | 50MG | $576 | 2024-03-01 | Buy |
| Sigma-Aldrich | 1298140 | Granisetron Related Compound D United States Pharmacopeia (USP) Reference Standard | 50890-83-0 | 15mg | $1500 | 2024-03-01 | Buy |
| TCI Chemical | M2143 | 1-Methylindazole-3-carboxylic Acid >98.0%(GC)(T) | 50890-83-0 | 1g | $116 | 2023-06-20 | Buy |
| TCI Chemical | M2143 | 1-Methylindazole-3-carboxylic Acid >98.0%(GC)(T) | 50890-83-0 | 5g | $278 | 2024-03-01 | Buy |
| Alfa Aesar | H26879 | 1-Methylindazole-3-carboxylic acid, 97% | 50890-83-0 | 1g | $32.65 | 2024-03-01 | Buy |
1-Methylindazole-3-carboxylic acid Chemical Properties,Uses,Production
Chemical Properties
Off White Solid
Uses
Granisetron Impurity D.
Uses
1-Methylindazole-3-carboxylic acid is used as important raw material and intermediate used in organic Synthesis, pharmaceuticals, agrochemicals and dyestuff. It is also used as a pharmaceutical adjuvant, Granisetron Impurity D.
Synthesis Reference(s)
The Journal of Organic Chemistry, 63, p. 8448, 1998 DOI: 10.1021/jo981557o
Synthesis
Calcium oxide (7.0 g, 0.124 mol, 2.0 molar equiv.) was added to technical methanol (150 ml), and the mixture was heated under reflux for 2 hours in a nitrogen atmosphere Indazole-3-carboxylic acid (10 g, 0.062 mol) was then added, and the reflux was continued for 2 hours. Dimethyl sulfate (15.6 g, 11.8 ml, 0.124 mole, 2.0 molar equiv.) was added dropwise under reflux for 2 hours, and the reflux continued for 2 hours. Water (100 ml) and 46% aqueous sodium hydroxide solution were added to produce a pH of about 14. Then, conc. hydrochloric acid was added to the reaction mixture to produce a pH of about 4. Calcium sulfate was collected by filtration and washed on a filter with hot methanol (3×30 ml). The methanol was removed under reduced pressure from the filtrate. The residuary mixture was stirred vigorously for 6 hours with a controlled pH of about 4. The solid product was collected by filtration, washed with water (3×30 ml), and dried in an oven at 50° C. overnight to give crude 1-Methylindazole-3-carboxylic acid.
Purification Methods
The crude 1-Methylindazole-3-carboxylic acid (1-MICA) (10.4 g) was treated by slurry in a methanol-water (3:7) mixture heated under reflux for 4 hours. The suspension was cooled to room temperature, and the solid product was collected by filtration, washed with the methanol-water (3:7) mixture (3×10 ml), and dried in an oven at 50° C. overnight to give pure 1-MICA (9.3 g, 85.6% yield, purity by HPLC: 99.70%).
1-Methylindazole-3-carboxylic acid Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Alfa Chemical Co., Ltd | +8615838112936 | alfa10@alfachem.cn | China | 13194 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531157085 | abby@chuanghaibio.com | China | 8808 | 58 |
| Hebei Mujin Biotechnology Co.,Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12809 | 58 |
| Hebei Zhuanglai Chemical Trading Co.,Ltd | +8613343047651 | admin@zlchemi.com | China | 3692 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29730 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-+86-371-66670886 | info@dakenam.com | China | 19805 | 58 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1803 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21628 | 55 |
| Shanghai Yingrui Biopharma Co., Ltd. | +86-21-33585366 - 03@ | sales03@shyrchem.com | CHINA | 738 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29858 | 58 |
View Lastest Price from 1-Methylindazole-3-carboxylic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-27 | 1-Methylindazole-3-carboxylic acid
50890-83-0
|
US $2380.00 / KG | 1KG | assay 97---102.0% | 50KG | WUHAN FORTUNA CHEMICAL CO., LTD | |
 |
2025-04-23 | 1-Methylindazole-3-carboxylic acid
50890-83-0
|
US $25.00 / ASSAYS | 100ASSAYS | 99.5% | 100 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2025-04-15 | 1-Methylindazole-3-carboxylic acid
50890-83-0
|
US $60.00 / kg | 1kg | 99% | 5000kg/week | Hebei Zhuanglai Chemical Trading Co.,Ltd |
-
- 1-Methylindazole-3-carboxylic acid
50890-83-0
- US $2380.00 / KG
- assay 97---102.0%
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- 1-Methylindazole-3-carboxylic acid
50890-83-0
- US $25.00 / ASSAYS
- 99.5%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 1-Methylindazole-3-carboxylic acid
50890-83-0
- US $60.00 / kg
- 99%
- Hebei Zhuanglai Chemical Trading Co.,Ltd