Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>3,3',4',5,6,7-HEXAHYDROXYFLAVONE

3,3',4',5,6,7-HEXAHYDROXYFLAVONE

3,3',4',5,6,7-HEXAHYDROXYFLAVONE Structure
3,3',4',5,6,7-HEXAHYDROXYFLAVONE structure
CAS No.
90-18-6
Chemical Name:
3,3',4',5,6,7-HEXAHYDROXYFLAVONE
Synonyms
QUERCETAGIN;QUERCETAGETIN;QUERCETAGENIN;6-Hydroxyquercetin;6,7,4'-Quercetagetin;QUEBRACHITOL, (-)-(RG);Quercetagetin 7-glucoside;Quercetagetin, 10 mM in DMSO;3,5,6,7,3',4'-HEXAHYDROXYFLAVONE;3,3',4',5,6,7-HEXAHYDROXYFLAVONE
CBNumber:
CB2737863
Molecular Formula:
C15H10O8
Molecular Weight:
318.24
MDL Number:
MFCD00017428
MOL File:
90-18-6.mol
MSDS File:
SDS
Last updated:2025-04-18 09:51:57
Request For Quotation

3,3',4',5,6,7-HEXAHYDROXYFLAVONE Properties

Melting point >300°C
Boiling point 732.4±60.0 °C(Predicted)
Density 1.912±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 125 mg/mL (392.79 mM; Need ultrasonic)
form A crystalline solid
pka 6.12±0.40(Predicted)
color Light yellow to yellow
LogP 2.230 (est)
FDA UNII SV68G507VO
UNSPSC Code 41116107
NACRES NA.77

3,3',4',5,6,7-HEXAHYDROXYFLAVONE price More Price(18)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 551590 Quercetagetin - CAS 90-18-6 - Calbiochem A cell-permeable flavanol compound that acts a potent, ATP-competitive, and reversible inhibitor of PIM1 kinase (IC?? = 340 nM). 90-18-6 5MG $362 2022-05-15 Buy
Cayman Chemical 18645 Quercetagetin ≥98% 90-18-6 500μg $73 2024-03-01 Buy
Cayman Chemical 18645 Quercetagetin ≥98% 90-18-6 1mg $131 2024-03-01 Buy
Cayman Chemical 18645 Quercetagetin ≥98% 90-18-6 5mg $324 2024-03-01 Buy
Usbiological 349627 Quercetagetin 90-18-6 500ug $296 2021-12-16 Buy
Product number Packaging Price Buy
551590 5MG $362 Buy
18645 500μg $73 Buy
18645 1mg $131 Buy
18645 5mg $324 Buy
349627 500ug $296 Buy

3,3',4',5,6,7-HEXAHYDROXYFLAVONE Chemical Properties,Uses,Production

Uses

Quercetagetin (6-Hydroxyquercetin) is a flavonoid[1]. Quercetagetin is a moderately potent and selective, cell-permeable pim-1 kinase inhibitor (IC50, 0.34 μM)[2]. Anti-inflammatory and anticancer properties.

Definition

ChEBI: A hexahydroxyflavone that is flavone substituted by hydroxy groups at positions 3, 5, 6, 7, 3' and 4' respectively.

Biological Activity

Cell permeable: yes', 'Primary Target
PIM1 kinase', 'Product competes with ATP.', 'Reversible: yes', 'Target IC50: 340 nM against PIM1 kinase

in vivo

Quercetagetin significantly inhibits UVB-induced skin cancer development. Topical application of 4 or 20 nmol of Quercetagetin to mouse skin reduces tumor incidence by 32.0% and 46.7%, respectively[3].

Animal Model:SKH-1 hairless mice model[3]
Dosage:4 or 20 nmol
Administration:Topical application; 28 weeks
Result:Inhibited UVB-induced skin tumorigenesis in SKH-1 hairless mice models. Delayed the development of tumors and reduced tumor volumes in an SKH-1 hairless mice model.

IC 50

PIM1: 0.34 μM (IC50); PIM2: 3.45 μM (IC50); RSK2: 2.82 μM (IC50); PKA: 21.2 μM (IC50)

References

[1] Yang X, et al. Isolation and identification of an antioxidant flavonoid compound from citrus-processing by-product. J Sci Food Agric. 2011 Aug 15;91(10):1925-7. DOI:10.1002/jsfa.4402
[2] Holder S, et al. Characterization of a potent and selective small-molecule inhibitor of the PIM1 kinase. Mol Cancer Ther. 2007 Jan;6(1):163-72. DOI:10.1158/1535-7163.MCT-06-0397
[3] Baek S, et al. Structural and functional analysis of the natural JNK1 inhibitor quercetagetin. J Mol Biol. 2013 Jan 23;425(2):411-23. DOI:10.1016/j.jmb.2012.10.019

3,3',4',5,6,7-HEXAHYDROXYFLAVONE Preparation Products And Raw materials

Raw materials

Preparation Products

3,3',4',5,6,7-HEXAHYDROXYFLAVONE Suppliers

Global( 120)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Zheyan Biotech Co., Ltd. 		18017610038 zheyansh@163.com CHINA 3619 58
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29858 58
Chengdu Biopurify Phytochemicals Ltd. 		+86-28-82633860; +8618080483897 sales@biopurify.com China 3772 58
Hubei Jusheng Technology Co.,Ltd. 		18871490254 linda@hubeijusheng.com CHINA 28172 58
Zhengzhou Alfa Chemical Co.,Ltd 		+8618530059196 sale04@alfachem.cn China 12162 58
Wuhan ChemNorm Biotech Co.,Ltd. 		+86-27-8439 4403 18971486879 sales@chemnorm.com CHINA 2935 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32159 58
Hubei Ipure Biology Co., Ltd 		+8613367258412 ada@ipurechemical.com China 10244 58
HONG KONG IPURE BIOLOGY CO.,LIMITED 		86 18062405514 18062405514 ada@ipurechemical.com CHINA 3461 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38630 58
Supplier Advantage
Shanghai Zheyan Biotech Co., Ltd. 		58
career henan chemical co 		58
Chengdu Biopurify Phytochemicals Ltd. 		58
Hubei Jusheng Technology Co.,Ltd. 		58
Zhengzhou Alfa Chemical Co.,Ltd 		58
Wuhan ChemNorm Biotech Co.,Ltd. 		58
TargetMol Chemicals Inc. 		58
Hubei Ipure Biology Co., Ltd 		58
HONG KONG IPURE BIOLOGY CO.,LIMITED 		58
TargetMol Chemicals Inc. 		58

View Lastest Price from 3,3',4',5,6,7-HEXAHYDROXYFLAVONE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Quercetagetin pictures 2024-11-19 Quercetagetin
90-18-6
 US $90.00-318.00 / mg 99.76% 10g TargetMol Chemicals Inc.
3,3',4',5,6,7-HEXAHYDROXYFLAVONE pictures 2019-07-06 3,3',4',5,6,7-HEXAHYDROXYFLAVONE
90-18-6
 US $1.00 / KG 1g 99% 100KG Career Henan Chemical Co
  • Quercetagetin pictures
  • Quercetagetin
    90-18-6
  • US $90.00-318.00 / mg
  • 99.76%
  • TargetMol Chemicals Inc.

90-18-6(3,3',4',5,6,7-HEXAHYDROXYFLAVONE)Related Search:

Quercetin 3-O-neohesperidoside Naringenin Quercetin-3-O-b-D-glucose-7-O-b-D-gentiobiosiden QUERCETIN-3-O-GLUCURONIDE quercetin 3-sambubioside
Quercitrin Quercetagetin-7-O-glucoside ARTEMETIN 3',4',5',3,5,7-HEXAHYDROXYFLAVONE,3,5,7,3',4',5'-HEXAHYDROXYFLAVONE,3,3μ,4μ,5,5μ,7-Hexahydroxyflavone, Cannabiscetin,3,3',4',5,5',7-HEXAHYDROXYFLAVONE 3,3',4',5,7,8-Hexahydroxyflavone,3,3',4',5,7,8-HEXAHYDROXYFLAVONE 8-GLUCOSIDE
CASTICIN 3,3',4',5,6,7-HEXAHYDROXYFLAVONE centaureidin 3,3',4',5,6,7,8-heptamethoxyflavone 5,3',4'-trihydroxy-3,6,7,8-tetramethoxyflavone
3,5,7,3',4',8-HEXAHYDROXYFLAVONE,3,5,7,8,3',4'-HEXAHYDROXYFLAVONE,3,5,7,8,3',4'-Hexahydroxyflavone,3,3',4',5,7,8-Hexahydroxyflavone 3',4',5,6,7,8-Hexahydroxyflavone centaurein

1of4

QUERCETAGIN QUERCETAGENIN QUERCETAGETIN 3,3',4',5,6,7-HEXAHYDROXYFLAVONE 3,5,6,7,3',4'-HEXAHYDROXYFLAVONE 2-(3,4-dihydroxyphenyl)-3,5,6,7-tetrahydroxy-4-benzopyrone 2-(3,4-Dihydroxyphenyl)-3,5,6,7-tetrahydroxy-4H-1-benzopyran-4-one 3,5,6,7-Tetrahydroxy-2-(3,4-dihydroxyphenyl)-4H-1-benzopyran-4-one 6,7,4'-Quercetagetin 6-Hydroxyquercetin QUEBRACHITOL, (-)-(RG) QuercetagitrinQuercetagetin 7-glucoside Quercetagetin 7-glucoside 2-(3,4-dihydroxyphenyl)-3,5,6,7-tetrahydroxy-1-benzopyran-4-one 4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-3,5,6,7-tetrahydroxy- 2-(3,4-Dihydroxyphenyl)-3,5,6,7-tetrahydroxy-4H-chromen-4-one Quercetagetin, 10 mM in DMSO 90-18-6 Flavanols