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12,12-DIBROMO-N-(METHYLSULFONYL)-11-DODECENAMIDE

CAS No.
206052-03-1
Chemical Name:
12,12-DIBROMO-N-(METHYLSULFONYL)-11-DODECENAMIDE
Synonyms
DDMS;DIBROMO-DODECENYL-METHYLSULFIMIDE;DDMS (Dibromo-dodecenyl-methylsulfimide);12,12-DIBROMO-N-(METHYLSULFONYL)-11-DODECENAMIDE;11-Dodecenamide, 12,12-dibromo-N-(methylsulfonyl)-
CBNumber:
CB2756877
Molecular Formula:
C13H23Br2NO3S
Molecular Weight:
433.2
MDL Number:
MFCD08062215
MOL File:
206052-03-1.mol
Last updated:2024-07-02 08:55:04

12,12-DIBROMO-N-(METHYLSULFONYL)-11-DODECENAMIDE Properties

Density 1.494±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility ≤20mg/ml in DMSO;30mg/ml in dimethyl formamide
pka 4.68±0.40(Predicted)
form solution in ethanol.
color White to off-white
FDA UNII B7RXR6O461

12,12-DIBROMO-N-(METHYLSULFONYL)-11-DODECENAMIDE price More Price(9)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 10018 DDMS ≥98% 206052-03-1 1mg $70 2024-03-01 Buy
Cayman Chemical 10018 DDMS ≥98% 206052-03-1 5mg $308 2024-03-01 Buy
Cayman Chemical 10018 DDMS ≥98% 206052-03-1 10mg $545 2024-03-01 Buy
TRC D195300 DDMS 206052-03-1 5mg $210 2021-12-16 Buy
TRC D195300 DDMS 206052-03-1 25mg $895 2021-12-16 Buy
Product number Packaging Price Buy
10018 1mg $70 Buy
10018 5mg $308 Buy
10018 10mg $545 Buy
D195300 5mg $210 Buy
D195300 25mg $895 Buy

12,12-DIBROMO-N-(METHYLSULFONYL)-11-DODECENAMIDE Chemical Properties,Uses,Production

Uses

DDMS is used as an irreversible inhibitor that has selectivity for the CYP4A2 enzyme which synthesizes 20-HETE in the mammalian kidney. 20-HETE plays an important role in vascular homeostasis.

Biological Activity

ddms is a cyp4a2 enzyme inhibitor.biosynthesis of 20-hete from arachidonic acid by the cytochrome p450 4a (cyp450 4a) isoforms is a key component of vascular homeostasis, especially in renal circulation.

in vitro

to determine whether inhibition of 20-hete contributes to the vasodilatory effects of no, the effects of ddms on the response to snp were examined in rat renal arterioles preconstricted with phenylephrine). results showed that after ddms treatment, snp could increase vascular diameter by only 17% [1].

in vivo

the effects of ddms on the mean arterial pressure and renal blood flow responses to infusion of an no donor and a synthase inhibitor were also examined. it was found that infusion of mahma nonoate at 1, 3, 5, and 10 nmol/min was able to reduce mean arterial pressure by 16, 30, 40, and 48 mm hg and lowered renal vascular resistance by 15 %, 26 %, 30%, and 34% of control. in addition, after ddms treatment at 10 mg/kg, the mean arterial pressure and renal vascular resistance responsed to 1-hexamine, 6-(2-hydroxy-1-methyl-2-nitrohydrazino)n-methyl averaged only 20% of those seen during control [1].

References

[1] alonso-galicia, m. ,drummond, h.a.,reddy, k.k., et al. inhibition of 20-hete production contributes to the vascular responses to nitric oxide. hypertension 29, 320-325 (1997).

12,12-DIBROMO-N-(METHYLSULFONYL)-11-DODECENAMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

12,12-DIBROMO-N-(METHYLSULFONYL)-11-DODECENAMIDE Suppliers

Global( 32)Suppliers
Supplier Tel Email Country ProdList Advantage
Aladdin Scientific
+1-+1(833)-552-7181 sales@aladdinsci.com United States 52924 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11218 58
MedBioPharmaceutical Technology Inc 021-69568360 18916172912 order@med-bio.cn China 8140 58
Energy Chemical 021-58432009 400-005-6266 marketing@energy-chemical.com China 44918 58
Shanghai Maclean Biochemical Technology Co., LTD 021-50706066 15221275939 shenlinxing@macklin.cn China 29902 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11974 58
4008-099-669 23419001name@qq.com CHINA 73043 58
ApexBio Technology -- sales@apexbt.com United States 6251 58

206052-03-1(12,12-DIBROMO-N-(METHYLSULFONYL)-11-DODECENAMIDE)Related Search:

12,12-DIBROMO-N-(METHYLSULFONYL)-11-DODECENAMIDE DDMS DIBROMO-DODECENYL-METHYLSULFIMIDE 11-Dodecenamide, 12,12-dibromo-N-(methylsulfonyl)- DDMS (Dibromo-dodecenyl-methylsulfimide) 206052-03-1 C13H23Br2NO3S