Bisantrene
- CAS No.
- 78186-34-2
- Chemical Name:
- Bisantrene
- Synonyms
- ADAH;CS-2227;Zantrene;CL-216942;BISANTRENE;NSC-337766;Orange Crush;BISANTRENE HCL;Bisantrene, >96%;Bisantrene USP/EP/BP
- CBNumber:
- CB2764144
- Molecular Formula:
- C22H22N8
- Molecular Weight:
- 398.46
- MDL Number:
- MFCD00872137
- MOL File:
- 78186-34-2.mol
- MSDS File:
- SDS
| Boiling point | 646.3±65.0 °C(Predicted) |
|---|---|
| Density | 1.41±0.1 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | deionized water: soluble8mg/mL |
| pka | 9.78±0.10(Predicted) |
| form | solid |
| color | Orange to red |
| InChIKey | NJSMWLQOCQIOPE-OCHFTUDZSA-N |
| SMILES | C1(/C=N/NC2=NCCN2)=C2C=CC=CC2=C(/C=N/NC2=NCCN2)C2C=CC=CC1=2 |
| FDA UNII | 39C34M111K |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS09 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H400 |
| Precautionary statements | P273-P301+P312+P330 |
| Hazard Codes | Xn,N |
| Risk Statements | 22-50/53 |
| Safety Statements | 60-61 |
| RIDADR | UN 2811 6.1 / PGIII |
| WGK Germany | 3 |
Bisantrene price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | B4563 | Bisantrene dihydrochloride ≥98% (HPLC) | 78186-34-2 | 10mg | $86.9 | 2024-03-01 | Buy |
| Sigma-Aldrich | B4563 | Bisantrene dihydrochloride ≥98% (HPLC) | 78186-34-2 | 50mg | $138 | 2024-03-01 | Buy |
| ChemScene | CS-6132 | Bisantrene 95.44% | 78186-34-2 | 25mg | $144 | 2021-12-16 | Buy |
| ChemScene | CS-6132 | Bisantrene 95.44% | 78186-34-2 | 50mg | $240 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0008652 | BISANTRENE 95.00% | 78186-34-2 | 10MG | $605.17 | 2021-12-16 | Buy |
Bisantrene Chemical Properties,Uses,Production
Originator
Bisantrene hydrochloride,ZYF Pharm Chemical
Uses
Antineoplastic.
Definition
ChEBI: A hydrazone resulting from the formal condensation of both of the aldehyde groups of anthracene-9,10-dicarbaldehyde with 2-hydrazinyl-4,5-dihydro-1H-imidazole.
Manufacturing Process
A 33.0 g (0.135 mole) of 2-methylthio-2-imidazoline hydroiodide is dissolved
in 300 ml of water and treated with 8 ml (0.16 mole) of hydrazine hydrate.
The mixture is stirred at room temperature for 20 hours and then taken to
dryness under reduced pressure. The residue is dissolved in 250 ml of water
and again taken to dryness under reduced pressure. The residue is
redissolved in 250 ml of water and added to a mixture of 250 ml of water, 25
ml of concentrated hydrochloric acid and 25 g of silver oxide. The resulting
mixture is stirred on a steam bath for 4 hours and then filtered. The filtrate is
reduced to dryness under reduced pressure. The residue is dissolved in 300
ml of ethanol and 20 ml of water at the boil, clarified and cooled at -10°C.
The precipitate is collected, washed with ethanol and ether and dried at 60°C
and then 110°C under reduced pressure. Yield of the 2-hydrazino-2-
imidazoline hydrochloride 11.6 g, melting point 177-180°C.
The 2-hydrazino-2-imidazoline monohydrochloride is converted to the
dihydrochloride by treatment with ethanol and concentrated hydrochloric acid.
A suspension of 3.46 g of the 2-hydrazino-2-imidazoline dihydrochloride and
2.34 g of 9,10-anthracenedicarboxaldehyde in 100 ml of ethanol is stirred and
heated under reflux for two hours. The mixture is cooled and the solid is
collected and washed with ethanol giving the desired product as a crystalline
orange solid, m.p. 288-289°C (dec.).
Therapeutic Function
Antineoplastic
Bisantrene Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd | +86-18341751992 +86-15382112998 | 757984502@qq.com | China | 892 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32957 | 60 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49374 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32165 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30240 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 22783 | 58 |
| Hangzhou Huarong Pharm Co., Ltd. | 571-86758373 +8613588754946 | sales@huarongpharm.com | CHINA | 3148 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38632 | 58 |
Related articles
- The biological activity and cytotoxicity of Bisantrene
- Bisantrene is a new anthracene anticancer agent active in the treatment of disseminated breast cancer.
- Dec 1，2023
View Lastest Price from Bisantrene manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-17 | Bisantrene
78186-34-2
|
US $34.00-101.00 / mg | 98.57% | 10g | TargetMol Chemicals Inc. | ||
 |
2024-10-22 | Bisantrene
78186-34-2
|
US $1.00 / KG | 1KG | MIn98%HPLC/LC | 100KGS | Career Henan Chemica Co | |
 |
2021-07-03 | Bisantrene USP/EP/BP
78186-34-2
|
US $1.10 / g | 1g | 99.9% | 100 Tons Min | Dideu Industries Group Limited |
-
- Bisantrene
78186-34-2
- US $34.00-101.00 / mg
- 98.57%
- TargetMol Chemicals Inc.
-
- Bisantrene
78186-34-2
- US $1.00 / KG
- MIn98%HPLC/LC
- Career Henan Chemica Co
-
- Bisantrene USP/EP/BP
78186-34-2
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited