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H-PRO-LEU-GLY-NH2

H-PRO-LEU-GLY-NH2 structure

CAS No.: 2002-44-0

Chemical Name:: H-PRO-LEU-GLY-NH2

Synonyms: MELANOSTATIN;MIF-1;PRO-LEU-GLY-NH2;MIF-I;PLG-NH2;MSH-R-IF;MIF, AMIDE;Melanostatin I;PRO-LEU-GLY AMIDE;H-PRO-LEU-GLY-NH2

CBNumber:: CB2779319

Molecular Formula:: C13H24N4O3

Molecular Weight:: 284.35

MDL Number:: MFCD00037866

MOL File:: 2002-44-0.mol

MSDS File:: SDS

Last updated:2025-04-17 18:22:24

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H-PRO-LEU-GLY-NH2 Properties

Melting point	122-123 °C(Solv: water (7732-18-5))
Boiling point	626.2±55.0 °C(Predicted)
Density	1.147±0.06 g/cm3(Predicted)
storage temp.	-15°C
solubility	≥59.1 mg/mL in DMSO; ≥50 mg/mL in EtOH; ≥50 mg/mL in H2O
pka	14.10±0.20(Predicted)
form	Lyophilized powder
Water Solubility	Soluble in water.
Sequence	H-Pro-Leu-Gly-NH2
FDA UNII	3KY24B4Q62

H-PRO-LEU-GLY-NH2 price More Price(23)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Alfa Aesar	J60045	Melanocyte-Stimulating Hormone-Release Inhibiting Factor, synthetic	2002-44-0	250mg	$58.4	2023-06-20	Buy
Alfa Aesar	J60045	Melanocyte-Stimulating Hormone-Release Inhibiting Factor, synthetic	2002-44-0	1g	$201	2023-06-20	Buy
Tocris	1929	Melanocyte-stimulatinghormonereleaseinhibitingfactor	2002-44-0	10	$72	2021-12-16	Buy
Usbiological	M2868-72S	Melanocyte Stimulating Hormone Release Inhibiting Factor	2002-44-0	1mg	$531	2021-12-16	Buy
Usbiological	255779	Melanocyte-stimulating hormone release inhibiting factor	2002-44-0	10mg	$310	2021-12-16	Buy

Product number	Packaging	Price	Buy
J60045	250mg	$58.4	Buy
J60045	1g	$201	Buy
1929	10	$72	Buy
M2868-72S	1mg	$531	Buy
255779	10mg	$310	Buy

H-PRO-LEU-GLY-NH2 Chemical Properties,Uses,Production

Uses

L-Prolyl-L-leucylglycinamide is shown to be effective in treating human depression with greater efficacy and faster onset of action than traditional anti-depressants.Also, it is used in the synthesis of novel analogs to be tested for their ability to enhance the binding of [3H]-N-propylnorapomorphine to short isoform of human dopamine D2 receptors.

Definition

ChEBI: Melanostatin is an oligopeptide.

Biological Activity

melanocyte stimulating hormone release inhibiting factor,(c13h24n4o3), a tri-peptide with the sequence h2n-pro-leu-gly-amide, mw= 284.35. melanocyte-inhibiting factor (also known as pro-leu-gly-nh2, melanostatin, msh release-inhibiting hormone or mif-1) is an endogenous peptide fragment derived from cleavage of the hormone oxytocin, but having generally different actions in the body(1). mif-1 produces multiple effects, both blocking the effects of opioid receptor activation(2), while at the same time acting as a positive allosteric modulator of the d2 and d4 dopamine receptor subtypes, as well as inhibiting release of other neuropeptides such as alpha-msh, and potentiating melatonin activity(3). mif-1 is unusually resistant to metabolism in the bloodstream, and crosses the blood–brain barrier easily, though it is poorly active orally and is usually injected.figure1 formula of melanocyte stimulating hormone release inhibiting factor

in vivo

MIF-1 (Melanostatin, 1 mg/kg; i.p.; once, for 1 hour; male Wistar rats) modulates the analgesic effects and stress-induced analgesia (SIA)^[1].
MIF-1 (Melanostatin, 1 mg/kg; i.p.; daily, for 8 weeks; Sprague-Dawley rats) attenuates spiroperidol-induced impairment of development of striatal dopamine D2 receptors in rats^[3].

Animal Model:	Male Wistar rats^[1]
Dosage:	1 mg/kg
Administration:	Intraperitoneal injection; once, for 1 hour
Result:	Decreased the analgesic effect. Increased the pain threshold for at least 1 h.

Animal Model:	Sprague-Dawley rats^[3]
Dosage:	1 mg/kg
Administration:	Intraperitoneal injection; daily, for 8 weeks
Result:	Attenuated the ontogenic impairment of striatal D2 receptors that was produced by spiroperidol (HY-B1371) treatment.

storage

-20°C (desiccate)

References

1. Celis ME, Taleisnik S, Walter R (July 1971). "Regulation of formation and proposed structure of the factor inhibiting the release of melanocyte-stimulating hormone". Proceedings of the National Academy of Sciences of the United States of America 68 (7): 1428–33.2. Contreras PC, Takemori AE (June 1984). "Effect of prolyl-leucyl-glycinamide and alpha-melanocyte-stimulating hormone on levorphanol-induced analgesia, tolerance and dependence". Life Sciences 34 (26): 2559–66.3. Sandyk R (May 1990). "MIF-induced augmentation of melatonin functions: possible relevance to mechanisms of action of MIF-1 inmovement disorders". The International Journal of Neuroscience 52 (1-2): 59–65.

H-PRO-LEU-GLY-NH2 Preparation Products And Raw materials

Raw materials

Preparation Products

H-PRO-LEU-GLY-NH2 Suppliers

Global( 110)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shaanxi Dideu Medichem Co. Ltd	+86-29-81148696 +86-15536356810	1022@dideu.com	China	3883	58
Wuhan senwayer century chemical Co.,Ltd	+undefined-27-86652399 +undefined13627115097	market02@senwayer.com	China	923	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10406	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19552	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29808	58
Hebei Yanxi Chemical Co., Ltd.	+8617531153977	allison@yan-xi.com	China	5854	58
Finetech Industry Limited	+86-27-8746-5837 +8619945049750	info@finetechnology-ind.com	China	9642	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10473	58
Hangzhou Go Top Peptide Biotech	0571-88211921	sales1@gotopbio.com	CHINA	2609	58
Nextpeptide Inc	+86-0571-81612335 +8613336028439	sales@nextpeptide.com	China	19908	58

Supplier	Advantage
Shaanxi Dideu Medichem Co. Ltd	58
Wuhan senwayer century chemical Co.,Ltd	58
Shenzhen Nexconn Pharmatechs Ltd	58
BOC Sciences	58
career henan chemical co	58
Hebei Yanxi Chemical Co., Ltd.	58
Finetech Industry Limited	58
Zhejiang J&C Biological Technology Co.,Limited	58
Hangzhou Go Top Peptide Biotech	58
Nextpeptide Inc	58

View Lastest Price from H-PRO-LEU-GLY-NH2 manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-01-17	MIF-1 (pro-Leu-Gly-NH2) 2002-44-0	US $0.00 / g	1g	99% min	20 tons	Wuhan Senwayer Century Chemical Co.,Ltd
2024-07-14	H-PRO-LEU-GLY-NH2 2002-44-0	US $0.10 / KG	1KG	98.0%	10	Shaanxi Dideu Medichem Co. Ltd
2020-02-14	H-PRO-LEU-GLY-NH2 2002-44-0	US $7.00 / KG	1KG	99%	100KG	Career Henan Chemical Co

MIF-1 (pro-Leu-Gly-NH2)
2002-44-0
US $0.00 / g
99% min
Wuhan Senwayer Century Chemical Co.,Ltd

H-PRO-LEU-GLY-NH2
2002-44-0
US $0.10 / KG
98.0%
Shaanxi Dideu Medichem Co. Ltd

H-PRO-LEU-GLY-NH2
2002-44-0
US $7.00 / KG
99%
Career Henan Chemical Co

H-PRO-LEU-GLY-NH2 Spectrum

H-PRO-LEU-GLY-NH2(2002-44-0)MS

2002-44-0(H-PRO-LEU-GLY-NH2)Related Search:

Carbetocin Oxytocin free acid Oxytocin Z-PRO-LEU-GLY-NH2 H-TYR-PRO-LEU-GLY-NH2,TYR-PRO-LEU-GLY-NH2

CYS-TYR-ILE-GLN-ASN-CYS-PRO-LEU-GLY-NH2 ACETATE SALT BIOTIN-CYS-TYR-ILE-GLN-ASN-CYS-PRO-LEU-GLY-NH2,BIOTIN-CYS-TYR-ILE-GLN-ASN-CYS-PRO-LEU-GLY-NH2 (DISULFIDE BRIDGE: 1-6) H-PRO-LEU-GLY-NH2 H2O,L-PRO-LEU-GLY NH2 HEMIHYDRATE CYCLO(TYR-ILE-GLN-ASN-ASU)-PRO-LEU-GLY-NH2,TYR-ILE-GLN-ASN-ASU-PRO-LEU-GLY-NH2 H-CYS-TYR-ILE-GLN-ASN-CYS-PRO-LEU-GLY-NH-CH2CH2F

N-(4-Oxo-4H-3,1-benzoxazin-2-yl)-Pro-Leu-Gly-NH2 PRO-LEU-GLY-NH2 1/2H2O Cys(Bzl)-Pro-Leu-Gly-NH2 Z–GLN–ASN–CYS(BZL)–PRO–LEU–GLY–NH2 H-CYS-TYR-ILE-GLN-ASN-CYS-PRO-LEU-GLY-NH-CH2CH2F, (DISULFIDE BOND)

BOC-ASN-CYS(ACM)-PRO-LEU-GLY-NH2 H2O OXYTOCIN = H-CYS-TYR-ILE-GLN-ASN-CYS-PRO-LEU-GLY-NH2 DISULFIDE BOND CYS-TYR-ILE-GLN-ASN-CYS-PRO-LEU-GLY-NH2 ACETATE SALT HYDRATE

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MELANOCYTE STIMULATING HORMONE RELEASE INHIBITING FACTOR MELANOCYTE STIMULATING HORMONE RELEASE INHIBITING FACTOR, AMIDE MELANOCYTE STIMULATING HORMONE RELEASING FACTOR H-PRO-LEU-GLY-NH2 L-Prolyl-L-leucylglycinamide, hemihydrate L-prolyl-L-leucylglycinamide MSH-RELEASE INHIBITING FACTOR MSH RELEASE INHIBITING FACTOR, AMIDE MIF, AMIDE MIF-I PRO-LEU-GLY AMIDE PLG-NH2 MIF-I, Melanostatin, Melanotropin Release-Inhibiting Factor Melanostatin, MIF-I, Oxytocin fragment 7-9 Melanocyte-stimulating hormone release inhibiting factor I Melanocyte-stimulating hormone release-inhibiting factor I Melanostatin I MSH-release inhibiting factor I PRO-LEU-GLY AMIDE;MIF-I;OXYTOCIN FRAGMENT 7-9 (2S)-N-[(1S)-1-[(2-amino-2-keto-ethyl)carbamoyl]-3-methyl-butyl]pyrrolidine-2-carboxamide (2S)-N-[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]pyrrolidine-2-carboxamide (2S)-N-[(2S)-1-[(2-azanyl-2-oxo-ethyl)amino]-4-methyl-1-oxo-pentan-2-yl]pyrrolidine-2-carboxamide (S)-N-((S)-1-((2-Amino-2-oxoethyl)amino)-4-methyl-1-oxopentan-2-yl)pyrrolidine-2-carboxamide MIF-1;MSH-R-IF;MELANOCYTE-STIMULATING HORMONE RELEASE-INHIBITING FACTOR MSH-R-IF Glycinamide, L-prolyl-L-leucyl- Melanocyte-stimulati MELANOSTATIN MIF-1 PRO-LEU-GLY-NH2 Oxytocin C-terminal tripeptide Melanocyte-Stimulating Hormone-Release Inh,MSH Release Inhibiting Factor, amide L-Prolyl-L-Leucyl-Glycinamide TFA salt MIF-1 (pro-Leu-Gly-NH2) 2002-44-0 C13H24N4O3 Cytokines, Growth Factors and Hormones Pituitary Hormones Oxytocin Hormones Cell Signaling and Neuroscience Cell Biology BioChemical SignalTransduction Melanocortin receptor peptide Elisa Kit-Mouse Elisa Kit