FGFR1/DDR2 inhibitor 1
- CAS No.
- 2308497-58-5
- Chemical Name:
- FGFR1/DDR2 inhibitor 1
- Synonyms
- ZUN97585;FGFR1/DDR2 inhibitor 1;ZUN97585(FGFR1/DDR2 inhibitor 1);3-(3-(1-Cyclopropyl-1H-pyrazol-4-yl)-1H-indazol-6-yl)-4-methyl-N-(3-(trifluoromethyl)phenyl)benzamide;Benzamide, 3-[3-(1-cyclopropyl-1H-pyrazol-4-yl)-1H-indazol-6-yl]-4-methyl-N-[3-(trifluoromethyl)phenyl]-;Inhibitor,NCI-H1581,FGFR-1/DDR2 inhibitor 1,FGFR1/DDR2 inhibitor 1,NCI-H2286,inhibit,cells,Nude,phosphorylation,mice,Fibroblast growth factor receptor,Discoidin Domain Receptor,tumor,SCID,FGFR
- CBNumber:
- CB28054401
- Molecular Formula:
- C28H22F3N5O
- Molecular Weight:
- 501.5
- MDL Number:
- MFCD32067903
- MOL File:
- 2308497-58-5.mol
FGFR1/DDR2 inhibitor 1 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0082049 | FGFR1/DDR2inhibitor1 99.03% | 2308497-58-5 | 5mg | $400 | 2021-12-16 | Buy |
| ChemScene | CS-0082049 | FGFR1/DDR2inhibitor1 99.03% | 2308497-58-5 | 10mg | $680 | 2021-12-16 | Buy |
| ChemScene | CS-0082049 | FGFR1/DDR2inhibitor1 99.03% | 2308497-58-5 | 25mg | $1350 | 2021-12-16 | Buy |
| ChemScene | CS-0082049 | FGFR1/DDR2inhibitor1 99.03% | 2308497-58-5 | 50mg | $2200 | 2021-12-16 | Buy |
| ChemScene | CS-0082049 | FGFR1/DDR2inhibitor1 99.03% | 2308497-58-5 | 100mg | $3400 | 2021-12-16 | Buy |
FGFR1/DDR2 inhibitor 1 Chemical Properties,Uses,Production
Biological Activity
FGFR1/DDR2 inhibitor 1 is an orally active inhibitor of fibroblast growth factor receptor 1 (FGFR1) and discoindin domain receptor 2 (DDR2), with IC50 values of 31.1 nM and 3.2 nM, respectively. Antitumor activity[1]. FGFR1/DDR2 inhibitor 1 (compound 11k) (25-200 μM; 2 hours) shows significant inhibition of FGFR2 phosphorylation in a dose-dependent manner in SNU16 cells. FGFR1/DDR2 inhibitor 1 shows (60-250 μM; 2 hours) significant inhibition of DDR2 phosphorylation in a dose-dependent manner in H2286 cells[1]. FGFR1/DDR2 inhibitor 1 significantly inhibits the proliferation of FGFR-driven cancer cell lines with IC50s of 108.4, 93.4, 31.8 and 306.6 nM against KG-1, SNU-16, NCI-H716 and UMUC14 respectively. FGFR1/DDR2 inhibitor 1 demonstrates substantially activity against the DDR2-driven cancer cell line NCI-H2286 (93.0 nM)[1]. FGFR1/DDR2 inhibitor 1 (10-20 mg/kg; p.o.; once daily for 7 days) has profound anti-tumor efficacy in NCI-H1581 tumor model[1].SCID mice bearing NCI-H2286 tumors were randomized and treated with FGFR1/DDR2 inhibitor 1 at doses of 10 mg/kg for 10 consecutive days. FGFR1/DDR2 inhibitor 1 could suppress tumor growth with tumor growth inhibition rates (TGI) of 82.8%[1].
References
[1]. Wang Q, et al. Discovery and optimization of a series of 3-substituted indazole derivatives as multi-target kinase inhibitors for the treatment of lung squamous cell carcinoma. Eur J Med Chem. 2019 Feb 1;163:671-689.
FGFR1/DDR2 inhibitor 1 Preparation Products And Raw materials
Raw materials
Preparation Products
FGFR1/DDR2 inhibitor 1 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32715 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Shanghai Chaolan Chemical Technology Center | QQ:65489617 15618227136 | info@SuperLan-chem.com | China | 9854 | 58 |
| Shanghai Dongyang Biotechnology Co., Ltd. | 0512-0512-13601744364 13601744364 | chemsharker@126.com | China | 884 | 58 |
| DC Chemicals | 021-58447131 13564518121 | sales@dcchemicals.com | China | 9412 | 58 |
| cjbscvictory | 13348960310 13348960310 | 3003867561@qq.com | China | 10011 | 58 |
| Bide Pharmatech Ltd. | 400-1647117 15221909166 | product02@bidepharm.com | China | 63720 | 58 |
| InvivoChem | 13549236410 | sales@invivochem.cn | China | 6749 | 58 |
| Supplier | Advantage |
|---|---|
| ATK CHEMICAL COMPANY LIMITED | 60 |
| TargetMol Chemicals Inc. | 58 |
| InvivoChem | 58 |
| Aladdin Scientific | 58 |
| Shanghai Chaolan Chemical Technology Center | 58 |
| Shanghai Dongyang Biotechnology Co., Ltd. | 58 |
| DC Chemicals | 58 |
| cjbscvictory | 58 |
| Bide Pharmatech Ltd. | 58 |
| InvivoChem | 58 |