Hexanamide, 6-[4-(1,4,5,6,7,8-hexahydro-7-methyl-4-oxopyrido[4',3':4,5]thieno[2,3-d]pyrimidin-2-yl)-2,6-dimethylphenoxy]-N-hydroxy-
![Hexanamide, 6-[4-(1,4,5,6,7,8-hexahydro-7-methyl-4-oxopyrido[4',3':4,5]thieno[2,3-d]pyrimidin-2-yl)-2,6-dimethylphenoxy]-N-hydroxy- Structure](CAS/20210111/GIF/2414373-11-6.gif)
- CAS No.
- 2414373-11-6
- Chemical Name:
- Hexanamide, 6-[4-(1,4,5,6,7,8-hexahydro-7-methyl-4-oxopyrido[4',3':4,5]thieno[2,3-d]pyrimidin-2-yl)-2,6-dimethylphenoxy]-N-hydroxy-
- Synonyms
- CAY17c;CAY17c,CAY-17c;Hexanamide, 6-[4-(1,4,5,6,7,8-hexahydro-7-methyl-4-oxopyrido[4',3':4,5]thieno[2,3-d]pyrimidin-2-yl)-2,6-dimethylphenoxy]-N-hydroxy-
- CBNumber:
- CB28176743
- Molecular Formula:
- C24H30N4O4S
- Molecular Weight:
- 470.58
- MDL Number:
- MFCD34475781
- MOL File:
- 2414373-11-6.mol
Hexanamide, 6-[4-(1,4,5,6,7,8-hexahydro-7-methyl-4-oxopyrido[4',3':4,5]thieno[2,3-d]pyrimidin-2-yl)-2,6-dimethylphenoxy]-N-hydroxy- Properties
| Density | 1.38±0.1 g/cm3(Predicted) |
|---|---|
| storage temp. | -20°C |
| solubility | DMF: slightly soluble,DMSO: slightly soluble |
| form | A crystalline solid |
| pka | 9.46±0.20(Predicted) |
Hexanamide, 6-[4-(1,4,5,6,7,8-hexahydro-7-methyl-4-oxopyrido[4',3':4,5]thieno[2,3-d]pyrimidin-2-yl)-2,6-dimethylphenoxy]-N-hydroxy- Chemical Properties,Uses,Production
Biological Activity
CAY17c is an inhibitor of bromodomain-containing protein 4 (BRD4; IC50 = 0.71 μM), as well as class I histone deacetylases (HDACs; IC50s = 0.046, 0.058, 0.075, and 0.167 μM for HDAC1, -2, -3, and -8, respectively) and class IIb HDACs (IC50s = 0.073 and 0.923 μM for HDAC6 and HDAC10, respectively).1 It is selective for these enzymes over BRD2, -3, and -T (IC50s = >20 μM for all), as well as over HDAC4, -5, -7, -9, and -11 (IC50s = >10 μM for all). CAY17c inhibits the proliferation of HCT116, SW620, and DLD-1 colorectal cancer cells (IC50s = 0.45, 1.78, and 2.11 μM, respectively), as well as induces apoptosis and autophagy in HCT116 cells. It reduces tumor growth in an HCT116 mouse xenograft model when administered at doses of 15 and 30 mg/kg.
References
1.Pan, Z., Li, X., Wang, Y., et al.Discovery of thieno[2,3-d]pyrimidine-based hydroxamic acid derivatives as bromodomain-containing protein 4/histone deacetylase dual inhibitors induce autophagic cell death in colorectal carcinoma cellsJ. Med. Chem.63(7)3678-3700(2020)
Hexanamide, 6-[4-(1,4,5,6,7,8-hexahydro-7-methyl-4-oxopyrido[4',3':4,5]thieno[2,3-d]pyrimidin-2-yl)-2,6-dimethylphenoxy]-N-hydroxy- Preparation Products And Raw materials
Raw materials
Preparation Products
Hexanamide, 6-[4-(1,4,5,6,7,8-hexahydro-7-methyl-4-oxopyrido[4',3':4,5]thieno[2,3-d]pyrimidin-2-yl)-2,6-dimethylphenoxy]-N-hydroxy- Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32038 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11974 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 19711 | 58 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 58 |
| TargetMol Chemicals Inc. | 58 |
