ChemicalBook >> CAS DataBase List >>EST64454
EST64454
- CAS No.
- 1950569-11-5
- Chemical Name:
- EST64454
- Synonyms
- EST64454;EST64454 HCl;EST64454 hydrochloride;pain,Inhibitor,EST 64454,EST64454 hydrochloride,nerve,selective,EST-64454 hydrochloride,Sigma Receptor,EST-64454,oral,inhibit
- CBNumber:
- CB28210252
- Molecular Formula:
- C18H23ClF2N4O2
- Molecular Weight:
- 400.85
- MDL Number:
- MFCD33023223
- MOL File:
- 1950569-11-5.mol
Last updated:2024-07-02 08:55:04
EST64454 price
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
ChemScene | CS-0144561 | EST64454hydrochloride 99.19% | 1950569-11-5 | 5mg | $350 | 2021-12-16 | Buy |
ChemScene | CS-0144561 | EST64454hydrochloride 99.19% | 1950569-11-5 | 10mg | $550 | 2021-12-16 | Buy |
ChemScene | CS-0144561 | EST64454hydrochloride 99.19% | 1950569-11-5 | 25mg | $950 | 2021-12-16 | Buy |
ChemScene | CS-0144561 | EST64454hydrochloride 99.19% | 1950569-11-5 | 50mg | $1450 | 2021-12-16 | Buy |
ChemScene | CS-0144561 | EST64454hydrochloride 99.19% | 1950569-11-5 | 100mg | $2250 | 2021-12-16 | Buy |
EST64454 Chemical Properties,Uses,Production
Biological Activity
EST64454 hydrochloride is a selective and orally active sigma-1 receptor antagonist with a Ki of 22 nM. EST64454 hydrochloride has the potential for the research of the pain[1]. EST64454 (10 mg/kg; p.o.; male Wistar rats) treatment shows the Cmax, t1/2, AUC0-∞, Vss and F% are 771 ng/mL, 3.4 hours, 1431 ng h/mL, 4.4 l/kg and 69%, respectively[1].EST64454 (10 mg/kg; p.o.; male CD1 mice) treatment shows the Cmax, t1/2, AUC0-∞, Vss and F% were 1178 ng/mL, <1 hours, 2645 ng h/mL, 1.2 l/kg and 60%, respectively[1].
References
[1]. Díaz JL, et al. EST64454: a Highly Soluble σ1 Receptor Antagonist Clinical Candidate for Pain Management. J Med Chem. 2020;63(23):14979-14988.
EST64454 Preparation Products And Raw materials
Raw materials
Preparation Products
EST64454 Suppliers
Global( 12)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32760 | 60 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
Shanghai Chaolan Chemical Technology Center | QQ:65489617 15618227136 | info@SuperLan-chem.com | China | 9887 | 58 |
DC Chemicals | 021-58447131 13564518121 | sales@dcchemicals.com | China | 9412 | 58 |
Wuhan Augda Biotechnology Co., Ltd | 15071299552 | 262933239@qq.com | China | 6654 | 58 |
InvivoChem | 13549236410 | sales@invivochem.cn | China | 6749 | 58 |
TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24016 | 58 |
EST64454
EST64454 hydrochloride
EST64454 HCl
pain,Inhibitor,EST 64454,EST64454 hydrochloride,nerve,selective,EST-64454 hydrochloride,Sigma Receptor,EST-64454,oral,inhibit
1950569-11-5