Adenosine, N-(3-hydroxyphenyl)-, 2',3',5'-triacetate
- CAS No.
- 1221412-23-2
- Chemical Name:
- Adenosine, N-(3-hydroxyphenyl)-, 2',3',5'-triacetate
- Synonyms
- IMM-H007;IMM-H007, 10 mM in DMSO;triacetyl-3-hydroxyphenyladenosine;Adenosine, N-(3-hydroxyphenyl)-, 2',3',5'-triacetate;(2R,3R,4R,5R)-2-(acetoxymethyl)-5-(6-((3-hydroxyphenyl)amino)-9H-purin-9-yl)tetrahydrofuran-3,4-diyl diacetate;JNK,Nuclear factor-κB,WS 070117,IMM H007,AP-1,inflammatory,WS070117,inhibit,AMPK,atherosclerosis,IMM-H007,Transforming growth factor beta receptors,Activator Protein 1,cardiac fibrosis,IMM-H-007,JNK/c-Jun,IMMH007,NF-κB,Nonalcoholic fatty liver disease,NAFLD,WS-070117,TGF-β Receptor,AMP-activated protein kinase,Nuclear factor-kappaB,Inhibitor
- CBNumber:
- CB28236043
- Molecular Formula:
- C22H23N5O8
- Molecular Weight:
- 485.45
- MDL Number:
- MFCD34187220
- MOL File:
- 1221412-23-2.mol
| Boiling point | 684.6±65.0 °C(Predicted) |
|---|---|
| Density | 1.54±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO: 97 mg/mL (199.81 mM);Ethanol: Insoluble |
| pka | 9.56±0.10(Predicted) |
| form | Solid |
| color | White to off-white |
| Water Solubility | Water: Insoluble |
Adenosine, N-(3-hydroxyphenyl)-, 2',3',5'-triacetate Chemical Properties,Uses,Production
Uses
IMM-H007 (WS070117) is an orally active and potent AMPK (AMP-activated protein kinase) activator and TGFβ1 (transforming growth factor β1) antagonist. IMM-H007 has protective effects in cardiovascular diseases via activation of AMPK. IMM-H007 negatively regulates endothelium inflammation through inactivating NF-κB and JNK/AP1 signaling. IMM-H007 inhibits ABCA1 degradation. IMM-H007 resolves hepatic steatosis in HFD-fed hamsters by the regulation of lipid metabolism. IMM-H007 can be used for the research of nonalcoholic fatty liver disease (NAFLD) and inflammatory atherosclerosis[1][2][3].
in vivo
IMM-H007 inhibits fatty acid import into hepatocytes and liver lipogenesis, and concomitantly stimulates fatty acid oxidation, autophagy, and export of hepatic lipids[2].
IMM-H007 (200?mg/kg, Orally, once per day for 10 days) inhibits ISO-induced cardiac fibrosis and diastolic dysfunction independently of AMPKα2 expression, reduces ISO-induced Smad2/3 phosphorylation downstream of TGFβ1 and cardiac fibrosis via an AMPKα2-independent pathway, but the inhibition of TGFβ1 expression is AMPKα2-dependent[3].
References
[1] Yu J, et al. IMM-H007, a novel small molecule inhibitor for atherosclerosis, represses endothelium inflammation by regulating the activity of NF-κB and JNK/AP1 signaling. Toxicol Appl Pharmacol. 2019 Oct 15;381:114732. DOI:10.1016/j.taap.2019.114732
[2] Shi H, et al. IMM-H007, a new therapeutic candidate for nonalcoholic fatty liver disease, improves hepatic steatosis in hamsters fed a high-fat diet. FEBS Open Bio. 2017 Aug 29;7(9):1379-1391. DOI:10.1002/2211-5463.12272
[3] Wang SX, et al. IMM-H007 attenuates isoprenaline-induced cardiac fibrosis through targeting TGFβ1 signaling pathway. Acta Pharmacol Sin. 2022 Mar 30. DOI:10.1038/s41401-022-00899-2
Adenosine, N-(3-hydroxyphenyl)-, 2',3',5'-triacetate Preparation Products And Raw materials
Raw materials
Preparation Products
Adenosine, N-(3-hydroxyphenyl)-, 2',3',5'-triacetate Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32159 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3135 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38630 | 58 | |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8467 | 58 |
| Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd | +86-18341751992 +86-15382112998 | 757984502@qq.com | China | 892 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43340 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 5221 | 58 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 | info@chemlin.com.cn | China | 19189 | 64 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4601 | 55 |
