L-Homoserine
- CAS No.
- 672-15-1
- Chemical Name:
- L-Homoserine
- Synonyms
- HOMOSERINE;HSE;(S)-2-AMINO-4-HYDROXYBUTANOIC ACID;H-HOMOSER-OH;H-HSE-OH;H-HOSER-OH;H-HOMOSERINE;(2S)-2-Amino-4-hydroxybutanoic acid;RODH;SDR9C6
- CBNumber:
- CB2854094
- Molecular Formula:
- C4H9NO3
- Molecular Weight:
- 119.12
- MDL Number:
- MFCD00063090
- MOL File:
- 672-15-1.mol
- MSDS File:
- SDS
| Melting point | 203 °C (dec.)(lit.) |
|---|---|
| Boiling point | 222.38°C (rough estimate) |
| alpha | -8.5 º (c=2, H2O 22 ºC) |
| Density | 1.3126 (rough estimate) |
| refractive index | 1.4183 (estimate) |
| storage temp. | Store below +30°C. |
| solubility | 1100g/l |
| form | Crystalline Powder |
| pka | 2.71(at 25℃) |
| color | White to light yellow |
| optical activity | -8.825 (H2O) +18.326 (2 mol dm-3 HCl) |
| Water Solubility | 1100 g/L (30 ºC) |
| Merck | 14,4739 |
| BRN | 1721681 |
| InChIKey | UKAUYVFTDYCKQA-VKHMYHEASA-N |
| LogP | -1.289 (est) |
| CAS DataBase Reference | 672-15-1(CAS DataBase Reference) |
| FDA UNII | 6KA95X0IVO |
| UNSPSC Code | 12352209 |
| NACRES | NA.26 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P271-P280 | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 24/25-44-35-26-28-7-4-3/9 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 10 | |||||||||
| HS Code | 29225000 | |||||||||
| NFPA 704 |
|
L-Homoserine price More Price(58)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | H6515 | L-Homoserine | 672-15-1 | 1g | $365 | 2024-03-01 | Buy |
| Sigma-Aldrich | H6515 | L-Homoserine | 672-15-1 | 5g | $1720 | 2024-03-01 | Buy |
| Sigma-Aldrich | 8.14359 | L-(-)-Homoserine for synthesis | 672-15-1 | 1g | $147 | 2024-03-01 | Buy |
| TCI Chemical | H1030 | L-Homoserine >98.0%(T) | 672-15-1 | 1g | $62 | 2024-03-01 | Buy |
| TCI Chemical | H1030 | L-Homoserine >98.0%(T) | 672-15-1 | 5g | $204 | 2024-03-01 | Buy |
L-Homoserine Chemical Properties,Uses,Production
Chemical Properties
white to light yellow crystalline powder
Uses
L-Homoserine is used in the biosynthesis of methionine, threonine and isoleucine. It is also used as an internal standard for neurotransmitter analysis and amino acids quantification.
Definition
ChEBI: L-homoserine is the L-enantiomer of homoserine. It has a role as a human metabolite, an algal metabolite, a Saccharomyces cerevisiae metabolite and an Escherichia coli metabolite. It is an enantiomer of a D-homoserine. It is a tautomer of a L-homoserine zwitterion.
Synthesis Reference(s)
Journal of the American Chemical Society, 80, p. 3147, 1958 DOI: 10.1021/ja01545a057
The Journal of Organic Chemistry, 24, p. 1794, 1959 DOI: 10.1021/jo01093a610
General Description
L-Homoserine is a variant of serine with an additional carbon on its side chain.
Biochem/physiol Actions
L-Homoserine is synthesized by deoxidation process, catalysed by homoserine dehydrogenase. This is one of the steps in the synthesis of L-threonine. The carbon flux in in bacteria such as E. coli is maintained by this reaction.
Purification Methods
Likely impurities are N-chloroacetyl-L-homoserine, N-chloroacetyl-D-homoserine, L-homoserine, homoserine lactone, homoserine anhydride (formed in strong solutions of homoserine if slightly acidic). It cyclises to the lactone in strongly acidic solution. It crystallises from water by adding 9 volumes of EtOH. [Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 pp 2612-2616 1961, Beilstein 4 IV 3187.]
L-Homoserine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Zhuanglai Chemical Trading Co Ltd | +86-16264648883 +86-16264648883 | niki@zlchemi.com | China | 3712 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29792 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21632 | 55 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | FandaChem@Gmail.com | China | 8441 | 55 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3009 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32965 | 60 |
| AB PharmaTech,LLC | 323-480-4688 | sales@acrospharmatech.com | United States | 989 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29871 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 18478 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
View Lastest Price from L-Homoserine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-02-14 | L-homoserine
672-15-1
|
US $50.00 / kg | 1kg | 99 | 5000 | Hebei Zhuanglai Chemical Trading Co Ltd | |
 |
2025-02-12 | L-Homoserine
672-15-1
|
US $0.00 / KG | 1KG | 98.0% | 5000kg/month | WUHAN FORTUNA CHEMICAL CO., LTD | |
 |
2024-11-19 | L-Homoserine
672-15-1
|
US $30.00-57.00 / mg | 99.42% | 10g | TargetMol Chemicals Inc. |
-
- L-homoserine
672-15-1
- US $50.00 / kg
- 99
- Hebei Zhuanglai Chemical Trading Co Ltd
-
- L-Homoserine
672-15-1
- US $0.00 / KG
- 98.0%
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- L-Homoserine
672-15-1
- US $30.00-57.00 / mg
- 99.42%
- TargetMol Chemicals Inc.
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