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D-Phenylalanine, N-[(phenylmethoxy)carbonyl]-L-phenylalanyl-, methyl ester

D-Phenylalanine, N-[(phenylmethoxy)carbonyl]-L-phenylalanyl-, methyl ester structure

CAS No.: 13122-87-7

Chemical Name:: D-Phenylalanine, N-[(phenylmethoxy)carbonyl]-L-phenylalanyl-, methyl ester

Synonyms: D-Phenylalanine, N-[(phenylmethoxy)carbonyl]-L-phenylalanyl-, methyl ester

CBNumber:: CB28645717

Molecular Formula:: C27H28N2O5

Molecular Weight:: 460.52

MDL Number:

MOL File:: 13122-87-7.mol

Last updated:2023-07-14 17:49:04

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D-Phenylalanine, N-[(phenylmethoxy)carbonyl]-L-phenylalanyl-, methyl ester Properties

Melting point	132-134 °C
Boiling point	687.7±55.0 °C(Predicted)
Density	1.206±0.06 g/cm3(Predicted)
pka	11.08±0.46(Predicted)

D-Phenylalanine, N-[(phenylmethoxy)carbonyl]-L-phenylalanyl-, methyl ester Chemical Properties,Uses,Production

Description

GSK-256066 is a PDE4 inhibitor.

in vitro

GSK256066 potently inhibited PDE4B enzymatic activity at sub-picomolar EC50 as previously reported._x000D_ _x000D_ Reference: Mol Ther. 2016 Dec;24(12):2078-2089. https://pubmed.ncbi.nlm.nih.gov/27731313/

in vivo

When administered intratracheally to rats, GSK256066 inhibited LPS-induced pulmonary neutrophilia with ED(50) values of 1.1 μg/kg (aqueous suspension) and 2.9 μg/kg (dry powder formulation) and was more potent than an aqueous suspension of the corticosteroid fluticasone propionate (ED(50) 9.3 μg/kg)._x000D_ _x000D_ Reference: J Pharmacol Exp Ther. 2011 Apr;337(1):145-54. https://pubmed.ncbi.nlm.nih.gov/21205923/

target

GSK-256066 is a PDE4 inhibitor.

D-Phenylalanine, N-[(phenylmethoxy)carbonyl]-L-phenylalanyl-, methyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

D-Phenylalanine, N-[(phenylmethoxy)carbonyl]-L-phenylalanyl-, methyl ester Suppliers

Global( 2)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Beijing Biocreative Technology Co., Ltd.	15522676233	3007606172@qq.com	China	1249	58
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	28118	58

Supplier	Advantage
Beijing Biocreative Technology Co., Ltd.	58
TargetMol Chemicals Inc.	58

D-Phenylalanine, N-[(phenylmethoxy)carbonyl]-L-phenylalanyl-, methyl ester 13122-87-7