ChemicalBook >> CAS DataBase List >>Acetamide, 2-bromo-N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)heptadecyl]-
Acetamide, 2-bromo-N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)heptadecyl]-
![Acetamide, 2-bromo-N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)heptadecyl]- Structure](CAS/20210305/GIF/886212-98-2.gif)
- CAS No.
- 886212-98-2
- Chemical Name:
- Acetamide, 2-bromo-N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)heptadecyl]-
- Synonyms
- SABRAC;Acetamide, 2-bromo-N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)heptadecyl]-
- CBNumber:
- CB28809852
- Molecular Formula:
- C20H40BrNO3
- Molecular Weight:
- 422.44
- MDL Number:
- MOL File:
- 886212-98-2.mol
Last updated:2023-05-21 10:59:17
| Melting point | 129-131 °C(Solv: hexane (110-54-3); acetone (67-64-1)) |
|---|---|
| Boiling point | 569.0±50.0 °C(Predicted) |
| Density | 1.130±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | Chloroform: soluble |
| form | A solid |
| pka | 12?+-.0.46(Predicted) |
Acetamide, 2-bromo-N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)heptadecyl]- Chemical Properties,Uses,Production
Biological Activity
SABRAC is an inhibitor of acid ceramidase (IC50 = 52 nM).1 It is selective for acid ceramidase over neutral ceramidase and the cysteine protease papain at 3 μM. SABRAC inhibits acid ceramidase in PC3 MC metastatic prostate cancer cells (IC50 = <1 μM), as well as induces accumulation of ceramides in the same cells. It completely inhibits anchorage-independent colony formation but does not induce cytotoxicity in PC3 MC cells when used at a concentration of 5 μM.
References
1.Camacho, L., Meca-Cortés, O., Abad, J.L., et al.Acid ceramidase as a therapeutic target in metastatic prostate cancerJ. Lipid Res.54(5)1207-1220(2013)
Acetamide, 2-bromo-N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)heptadecyl]- Preparation Products And Raw materials
Raw materials
Preparation Products
Acetamide, 2-bromo-N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)heptadecyl]- Suppliers
Global( 3)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11974 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 19711 | 58 |
| Supplier | Advantage |
|---|---|
| Shanghai Yifei Biotechnology Co. , Ltd. | 58 |
| TargetMol Chemicals Inc. | 58 |
Acetamide, 2-bromo-N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)heptadecyl]-
SABRAC
886212-98-2
C20H40BrNO3