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ChemicalBook >> CAS DataBase List >>5-Isoxazolecarboxamide, N-[2-methyl-5-[[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzoyl]amino]phenyl]-

5-Isoxazolecarboxamide, N-[2-methyl-5-[[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzoyl]amino]phenyl]-

5-Isoxazolecarboxamide, N-[2-methyl-5-[[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzoyl]amino]phenyl]- Structure
5-Isoxazolecarboxamide, N-[2-methyl-5-[[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzoyl]amino]phenyl]- structure
CAS No.
1135205-94-5
Chemical Name:
5-Isoxazolecarboxamide, N-[2-methyl-5-[[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzoyl]amino]phenyl]-
Synonyms
AWL-II-38.3;inhibit,AWL II 38.3,LIMK1,Inhibitor,LIMK2,EphA3,ATP,AWLII38.3;5-Isoxazolecarboxamide, N-[2-methyl-5-[[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzoyl]amino]phenyl]-
CBNumber:
CB29370113
Molecular Formula:
C23H18F3N5O3
Molecular Weight:
469.42
MDL Number:
MOL File:
1135205-94-5.mol
Last updated:2024-10-23 13:36:13
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5-Isoxazolecarboxamide, N-[2-methyl-5-[[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzoyl]amino]phenyl]- Properties

Boiling point 522.1±50.0 °C(Predicted)
Density 1.41±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 66.67 mg/mL (142.03 mM; Need ultrasonic)
form Solid
pka 11.30±0.70(Predicted)
color White to light yellow

5-Isoxazolecarboxamide, N-[2-methyl-5-[[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzoyl]amino]phenyl]- Chemical Properties,Uses,Production

Definition

ChEBI: N-[2-methyl-5-[[[3-(4-methyl-1-imidazolyl)-5-(trifluoromethyl)phenyl]-oxomethyl]amino]phenyl]-5-isoxazolecarboxamide is a member of benzamides.

Biological Activity

AWL-II-38.3 is a potent ephrin-A receptor (EphA3) kinase inhibitor. AWL-II-38.3 does not exhibit significant cellular activity against Src-family kinases nor against b-raf[1][2][1][2]. AWL-II-38.3 fits to LIMK2 and LIMK1 ATP-binding and substrate-binding pockets[2].

References

[1]. Yongmun Choi, et al. Discovery and structural analysis of Eph receptor tyrosine kinase inhibitors. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4467-70. [2]. Efrat Mashiach-Farkash, et al. Computer-based identification of a novel LIMK1/2 inhibitor that synergizes with salirasib to destabilize the actin cytoskeleton. Oncotarget. 2012 Jun;3(6):629-39.

5-Isoxazolecarboxamide, N-[2-methyl-5-[[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzoyl]amino]phenyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

5-Isoxazolecarboxamide, N-[2-methyl-5-[[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzoyl]amino]phenyl]- Suppliers

Global( 8)Suppliers
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TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32070 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38463 58
Shanghai Chaolan Chemical Technology Center QQ:65489617 15618227136 info@SuperLan-chem.com China 7034 58
Shanghai Dongyang Biotechnology Co., Ltd. 0512-0512-13601744364 13601744364 chemsharker@126.com China 917 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24648 58
Nanjing Tengyi Biotechnology Co., Ltd 025-58851786 17714337195 sales@tybiochem.com China 8043 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11974 58
https://hanhongsci.com/ 021-54306202 18917919676 info@hanhongsci.com China 29977 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
TargetMol Chemicals Inc. 		58
Shanghai Chaolan Chemical Technology Center 58
Shanghai Dongyang Biotechnology Co., Ltd. 58
TargetMol Chemicals Inc. 58
Nanjing Tengyi Biotechnology Co., Ltd 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
https://hanhongsci.com/ 58

View Lastest Price from 5-Isoxazolecarboxamide, N-[2-methyl-5-[[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzoyl]amino]phenyl]- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
AWL-II-38.3 pictures 2024-10-24 AWL-II-38.3
1135205-94-5
 US $74.00-278.00 / mg 99.87% 10g TargetMol Chemicals Inc.
  • AWL-II-38.3 pictures
  • AWL-II-38.3
    1135205-94-5
  • US $74.00-278.00 / mg
  • 99.87%
  • TargetMol Chemicals Inc.

5-Isoxazolecarboxamide, N-[2-methyl-5-[[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzoyl]amino]phenyl]- Spectrum

5-Isoxazolecarboxamide, N-[2-methyl-5-[[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzoyl]amino]phenyl]-(1135205-94-5)1HNMR
5-Isoxazolecarboxamide, N-[2-methyl-5-[[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzoyl]amino]phenyl]- AWL-II-38.3 inhibit,AWL II 38.3,LIMK1,Inhibitor,LIMK2,EphA3,ATP,AWLII38.3 1135205-94-5